<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-3347</journal-id>
<journal-title><![CDATA[Colombian Journal of Anestesiology]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. anestesiol.]]></abbrev-journal-title>
<issn>0120-3347</issn>
<publisher>
<publisher-name><![CDATA[SCARE-Sociedad Colombiana de Anestesiología y Reanimación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-33472018000200119</article-id>
<article-id pub-id-type="doi">10.1097/cj9.0000000000000023</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Analysis of the incidence of adverse events related to the administration of dipyrone]]></article-title>
<article-title xml:lang="es"><![CDATA[Análisis de la incidencia de eventos adversos relacionados a aplicación de dipirona]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Cárdenas]]></surname>
<given-names><![CDATA[Victor Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Laverde-Gaona]]></surname>
<given-names><![CDATA[Luis A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabarique-Serrano]]></surname>
<given-names><![CDATA[Sergio H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3 "/>
<xref ref-type="aff" rid="Af5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cháves-Rojas]]></surname>
<given-names><![CDATA[Nataly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reina-Sierra]]></surname>
<given-names><![CDATA[Jorge A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Infante]]></surname>
<given-names><![CDATA[Juan S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiroz-Díaz]]></surname>
<given-names><![CDATA[Laura M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meneses]]></surname>
<given-names><![CDATA[Victor D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud School of Medicine ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Sabana School of Medicine ]]></institution>
<addr-line><![CDATA[ Chía]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Hospital Infantil Universitario de San José Department of Anesthesiology ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,AUDIFARMA  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Clínica Universidad de la Sabana  ]]></institution>
<addr-line><![CDATA[ Chía]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>46</volume>
<numero>2</numero>
<fpage>119</fpage>
<lpage>125</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-33472018000200119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-33472018000200119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-33472018000200119&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Notwithstanding the widespread use of dipyrone, its association with adverse events has reduced its clinical use, with Agranulocytosis being the most studied adverse event, and apparently of primary clinical impact. Studies in Latin America have disputed these claims.  Objective: To analyze the incidence and reports of adverse events associated with the use of dipyrone in a high complexity hospital.  Materials and methods: Descriptive observational study of an incident cohort. Population: Patients receiving dipyrone during their hospital stay. Quantitative analysis of incidents and description of dipyrone-associated adverse events.  Results: Incidence of global adverse events=0.3% (in 48,946 doses of dipyrone prescribed to 2747 patients). No cases of Agranulocytosis. A total 100% non-severe adverse events. (All were associated with toxidermia).  Conclusion: A low incidence of dipyrone-associated adverse events is reported. Optimal reporting of institutional adverse events is controversial, and the recommendation is to measure any adverse events with a more rigorous follow-up of patients using dipyrone, and a clear and specific standardization of the guidelines for improved prescription and medical control.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: A pesar del amplio espectro de uso de la dipirona, su asociación a eventos adversos ha reducido su empleo clínico, siendo la agranulocitosis el evento adverso más estudiado, y al parecer de mayor impacto clínico. Estudios en América Latina han controvertido dichas afirmaciones.  Objetivo: Analizar la incidencia y reporte de eventos adversos asociados al uso de dipirona en un hospital de alta complejidad.  Materiales y métodos: Estudio observacional descriptivo de una cohorte Incidente. Población: Pacientes usuarios de dipirona durante su estancia hospitalaria. Análisis cuantitativo de Incidencias, y descriptivo de los casos incidentes de adversos relacionados al uso de dipirona.  Resultados: Incidencia de Eventos Adversos Globales=0,3% (En 48.496 dosis de dipirona formuladas en 2.747 pacientes). Ningún caso de Agranulocytosis. 100% de eventos adversos no severos (Todos asociados a reacción toxidérmica).  Conclusiones: Se reporta una baja incidencia de eventos adversos relacionados al uso de dipirona. Se controvierte la óptima ejecución de los reportes de eventos adversos institucionales. Se sugiere la realización de la medición de eventos adversos posterior a un más riguroso seguimiento de los pacientes usuarios de este medicamento, y a una estandarización clara y puntual de pautas para una mejor prescripción y control médico luego de su formulación.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Adverse Effects]]></kwd>
<kwd lng="en"><![CDATA[Dipyrone]]></kwd>
<kwd lng="en"><![CDATA[Incidence]]></kwd>
<kwd lng="en"><![CDATA[Observational Study]]></kwd>
<kwd lng="en"><![CDATA[Agranulocytosis]]></kwd>
<kwd lng="es"><![CDATA[Efectos Adversos]]></kwd>
<kwd lng="es"><![CDATA[Dipirona]]></kwd>
<kwd lng="es"><![CDATA[Incidencia]]></kwd>
<kwd lng="es"><![CDATA[Estudio Observacional]]></kwd>
<kwd lng="es"><![CDATA[Agranulocitosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nikolova]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Petkova]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Tencheva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole a review profile of a well-known &#8220;forgotten&#8221; drug. Part II: Clinical profile]]></article-title>
<source><![CDATA[Biotechnol Biotechnol Equip]]></source>
<year>2013</year>
<volume>27</volume>
<page-range>3605-19</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hearn]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Derry]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single dose dipyrone (metamizole) for acute postoperative pain in adults (review)]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2016</year>
<volume>4</volume>
<page-range>CD011421</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Derry]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Faura]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single dose dipyrone for acute postoperative pain]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2014</year>
<volume>9</volume>
<page-range>CD003227</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Meseguer]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Faura]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single dose dipyrone for acute renal colic pain]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2002</year>
<volume>4</volume>
<page-range>CD003867</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kötter]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[da Costa]]></surname>
<given-names><![CDATA[BR]]></given-names>
</name>
<name>
<surname><![CDATA[Fässler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole-associated adverse events a systematic review and meta-analysis]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2015</year>
<volume>10</volume>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<collab>The International Agranulocytosis.Aplastic Anemia StudyRisks of agranulocytosis and aplastic anemia</collab>
<article-title xml:lang=""><![CDATA[A first report of their relation to drug use with special reference to analgesics]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>1986</year>
<volume>256</volume>
<page-range>1749-57</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hedenmalm]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Spigset]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)]]></article-title>
<source><![CDATA[Eur J Clin Pharmacol]]></source>
<year>2002</year>
<volume>58</volume>
<page-range>265-74</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fieler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eich]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Becke]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metamizole for postoperative pain therapy in 1177 children a prospective, multicentre, observational, postauthorisation safety study]]></article-title>
<source><![CDATA[Eur J Anaesthesiol]]></source>
<year>2015</year>
<volume>32</volume>
<page-range>839843</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bigal]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bordini]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Speciali]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intravenous metamizol (dipyrone) in acute migraine treatment and in episodic tension-type headache-a placebo-controlled study]]></article-title>
<source><![CDATA[Cephalalgia]]></source>
<year>2001</year>
<volume>21</volume>
<page-range>90-5</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Meseguer]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Faura]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single dose dipyrone for acute postoperative pain]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2010</year>
<volume>9</volume>
<page-range>CD003227</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bigal]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Bordini]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Tepper]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura a randomized, double blind, placebo controlled study]]></article-title>
<source><![CDATA[Headache]]></source>
<year>2002</year>
<volume>42</volume>
<page-range>862-71</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hamerschlak]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Maluf]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Cavalcanti]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence and risk factors for agranulocytosis in Latin American countries-the Latin Study]]></article-title>
<source><![CDATA[Eur J Clin Pharmacol]]></source>
<year>2008</year>
<volume>64</volume>
<page-range>921-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ibanez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Ballarín]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Agranulocytosis associated with dipyrone (metamizol)]]></article-title>
<source><![CDATA[Eur J Clin Pharmacol]]></source>
<year>2005</year>
<volume>60</volume>
<page-range>821-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<collab>INVIMA</collab>
<article-title xml:lang=""><![CDATA[Comision Revisora-Sala Especializada de Medicamentos y Productos Biológicos]]></article-title>
<source><![CDATA[Informes de Seguridad (3.6.1. Dipirona). Acta No. 03. Sesión ordinaria-presencial del 23, 24, 25 y 26 de Febrero de 2015]]></source>
<year>2015</year>
<page-range>525-31</page-range><publisher-loc><![CDATA[Bogotá, Colombia ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hamerschlak]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Maluf]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pasquini]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence of aplastic anemia and agranulocytosis in Latin America the LATIN study]]></article-title>
<source><![CDATA[Sao Paulo Med J]]></source>
<year>2005</year>
<volume>123</volume>
<page-range>101-4</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ibáñez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Ballarín]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Population-based drug-induced agranulocytosis]]></article-title>
<source><![CDATA[Arch Intern Med]]></source>
<year>2005</year>
<volume>165</volume>
<page-range>869-74</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maj]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lis]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The incidence of metamizole sodium-induced agranulocytosis in Poland]]></article-title>
<source><![CDATA[J Int Med Res]]></source>
<year>2002</year>
<volume>30</volume>
<page-range>488-95</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borja]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Galindo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gomez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Delayed skin reactions to metamizol]]></article-title>
<source><![CDATA[Allergy]]></source>
<year>2003</year>
<volume>58</volume>
<page-range>84-5</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stamer]]></surname>
<given-names><![CDATA[UM]]></given-names>
</name>
<name>
<surname><![CDATA[Soehle]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Park T-W]]></surname>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anaphylactic reaction after intravenous dipyrone]]></article-title>
<source><![CDATA[Acute Pain]]></source>
<year>2007</year>
<volume>9</volume>
<page-range>221-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buitrago-González]]></surname>
<given-names><![CDATA[TP]]></given-names>
</name>
<name>
<surname><![CDATA[Calderón-Ospina]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Vallejos-Narváez]]></surname>
<given-names><![CDATA[Á]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dipirona ¿Benefícios subestimados o riesgos sobredimensiona-dos? Revisión de la literatura]]></article-title>
<source><![CDATA[Rev Colomb Cienc Quim Farm]]></source>
<year>2014</year>
<volume>43</volume>
<page-range>173-95</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Holloway]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Comitês de farmacoterapia, Guía practica]]></source>
<year></year>
<edition>1</edition>
<page-range>163</page-range><publisher-loc><![CDATA[Ginebra, Suiza ]]></publisher-loc>
<publisher-name><![CDATA[OMS]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
