<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-3347</journal-id>
<journal-title><![CDATA[Colombian Journal of Anestesiology]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. anestesiol.]]></abbrev-journal-title>
<issn>0120-3347</issn>
<publisher>
<publisher-name><![CDATA[SCARE-Sociedad Colombiana de Anestesiología y Reanimación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-33472018000400300</article-id>
<article-id pub-id-type="doi">10.1097/cj9.0000000000000079</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Factors associated with failed weaning from mechanical ventilation in adults on ventilatory support during 48 hours or more]]></article-title>
<article-title xml:lang="es"><![CDATA[Factores asociados a destete fallido de la ventilación mecánica en adultos con soporte ventilatorio igual y mayor a 48 horas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sandoval-Moreno]]></surname>
<given-names><![CDATA[Lina Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Henao]]></surname>
<given-names><![CDATA[William Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Santiago de Cali Physiotherapy Program ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle Exercise and Cardiopulmonary Health Research Group (GIESC) ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>46</volume>
<numero>4</numero>
<fpage>300</fpage>
<lpage>308</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-33472018000400300&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-33472018000400300&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-33472018000400300&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Failed weaning from mechanical ventilation (MV) has been reported in a proportion ranging from 10% to 20% of patients requiring ventilation support; this population has a longer duration of MV and risk of mortality.  Objective: To evaluate factors associated with failed weaning from MV.  Methodology: Descriptive study of a cohort of 139 patients, who participated in the clinical trial. Efficacy of respiratory muscle training (RMT) for weaning from MV in patients on MV during 48 hours or more. Clinical and sociodemographic exposure variables were measured. The outcome variable evaluated was failed weaning from MV. A descriptive analysis was carried out, and relative risks (RRs) were estimated using the Poisson regression. Single and multiple models were built.  Results: The incidence of failed weaning was 24.09%, 95% confidence interval (CI) 16.83 to 31.33. Independent associated factors were the respiratory system as the main compromised system upon admission to the intensive care unit (RR: 3.89; 95% CI 1.33-11.37; P = 0.01) and the Apache score (RR 0.96; 95% CI 0.920.98; P = 0.02). Modifiable factors such as pulmonary rehabilitation interventions, physical rehabilitation, RMT, and specific ventilatory strategies showed no association (P &gt;0.05).  Conclusion: There are non-modifiable factors related to failed weaning from MV in adults. Patients admitted to the intensive care unit with the respiratory system as the main system compromised have a higher risk of failed weaning; modifiable factors were not found to be associated with failed weaning in the population studied.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  El destete fallido de la ventilación mecánica se ha reportado en una proporción que va del 10 al 20% de los pacientes que requieren soporte ventilatorio; esta población presenta mayor duración de la ventilación mecánica y riesgo de mortalidad.  Objetivo:  Evaluar factores asociados a destete fallido de la ventilación mecánica en pacientes adultos con soporte ventila-torio igual y mayor a 48 horas  Metodología:  Estudio observacional de una cohorte de 139 pacientes, quienes participaron en el ensayo clínico. Eficacia del entrenamiento muscular respiratorio en el destete de la ventilación mecánica en pacientes con ventilación mecánica por 48 horas o más; variables de exposición clínicas y sociodemográficas fueron medidas. La variable resultado evaluada fue destete fallido de la ventilación mecánica. Se realizó análisis descriptivo, y se estimaron riesgos relativos a través de la regresión Poisson. Se construyeron modelos simples y un modelo múltiple.  Resultados:  La incidencia de destete fallido fue 24.09% [C95%:16.83-31.33.Los factores independientemente asociados fueron sistema respiratorio como principal comprometido al ingreso a UCI (RR:3.89 IC95%:1.33-11.37 p = 0.01) y apache (RR:0.96 IC95%:0.92-0.98 p = 0.02).Factores modificables como intervenciones de rehabilitación pulmonar, rehabilitación física, entrenamiento muscular respiratorio, y estrategias ventilatorias especificas no mostraron asociación (p&gt;0.05).  Conclusiones:  Factores no modificables están relacionados con el destete fallido de la ventilación mecánica en la población estudiada. El sistema respiratorio como principal comprometido al ingreso a la unidad de cuidado intensivo fue el factor de riesgo asociado a falla en el destete de la ventilación mecánica, los factores no modificables no se encontraron asociados con el evento estudiado.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Respiration]]></kwd>
<kwd lng="en"><![CDATA[Artificial]]></kwd>
<kwd lng="en"><![CDATA[Critical Care]]></kwd>
<kwd lng="en"><![CDATA[Weaning]]></kwd>
<kwd lng="en"><![CDATA[Intensive Care Units]]></kwd>
<kwd lng="en"><![CDATA[Adult]]></kwd>
<kwd lng="es"><![CDATA[Respiración artificial]]></kwd>
<kwd lng="es"><![CDATA[Cuidados críticos]]></kwd>
<kwd lng="es"><![CDATA[Destete]]></kwd>
<kwd lng="es"><![CDATA[Unidades de cuidados intensivos]]></kwd>
<kwd lng="es"><![CDATA[Adulto]]></kwd>
</kwd-group>
</article-meta>
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