<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-4157</journal-id>
<journal-title><![CDATA[Biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Biomédica]]></abbrev-journal-title>
<issn>0120-4157</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-41572020000500062</article-id>
<article-id pub-id-type="doi">10.7705/biomedica.5009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Prevalencia de leptospirosis en perros de trabajo vacunados y en población humana con riesgo ocupacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Prevalence of leptospirosis in vaccinated working dogs and humans with occupational risk]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murcia]]></surname>
<given-names><![CDATA[César A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Astudillo]]></surname>
<given-names><![CDATA[Miryam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero]]></surname>
<given-names><![CDATA[Marlyn H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Caldas  ]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Caldas Facultad de Ciencias Agropecuarias Departamento Salud Animal]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>05</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>05</month>
<year>2020</year>
</pub-date>
<volume>40</volume>
<fpage>62</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-41572020000500062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-41572020000500062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-41572020000500062&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. Los perros de trabajo pueden infectarse con diversas serovariedades de Leptospira que se mantienen en sus túbulos renales e intersticios por mucho tiempo, por lo que se convierten en portadores y fuentes de infección para otros huéspedes.  Objetivo. Establecer la prevalencia de Leptospira spp. en perros de trabajo vacunados y en población humana con riesgo ocupacional de seis unidades policiales en Colombia.  Materiales y métodos. Mediante tres instrumentos estructurados, se evaluaron 92 perros de trabajo con inmunización previa contra Leptospira spp. (65 machos y 27 hembras) y 69 personas de seis unidades policiales de los municipios de Manizales, Pereira, Armenia, Ibagué, Tuluá y Cali. Se obtuvieron muestras sanguíneas de las personas y de los perros, las cuales se evaluaron mediante la prueba de microaglutinación (Microscopic Agglutination Test, MAT) en 24 serogrupos. Se hizo un examen clínico de los perros y se obtuvieron muestras de orina para urocultivo.  Resultados. La seroprevalencia de leptospirosis en las personas fue de 2,9 % (n=2) y en los perros de 57,61 % (n=53). Los serogrupos más prevalentes en los perros fueron Leptospira canicola y L. panama. El urocultivo fue positivo en 58,7 % (54/92) de las muestras y se encontró asociación estadísticamente significativa entre la edad de los perros (&#8805;10 años; p=0,043) y la ubicación de la unidad policial (p=0,016).  Conclusión. Las características epidemiológicas de la leptospirosis en los perros sugieren una presentación endémica de la infección. Se requieren algoritmos diagnósticos sensibles y específicos para investigar la leptospirosis canina y diferenciar los anticuerpos vacunales de la infección natural.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Working dogs have been identified as a risk group for developing leptospirosis because they can be infected by Leptospira spp., which can be kept in the renal tubules and interstices for a long time, making them carriers and sources of infection for other hosts, including humans.  Objective: To establish the prevalence of Leptospira spp. in vaccinated working dogs and in the occupationally exposed population in six police units in Colombia.  Materials and methods: A total of 92 vaccinated dogs (65 males and 27 females) and 69 people from six police units in the municipalities of Manizales, Pereira, Armenia, Ibagué, Tuluá, and Cali were tested. Three structured instruments were applied and blood samples were obtained from people and dogs, which were processed with the microagglutination test (MAT) in 24 serogroups. A clinical examination of the dogs was performed and urine samples were obtained for urine cultures.  Results: The seroprevalence of human leptospirosis was 2.9% (n=2) and in dogs, it was 57.61% (n=53). Among the dogs, serogroups L. canicola and L. panama were the most prevalent. Urine cultures were positive in 58.7% (54/92) of the samples. A statistically significant association was found between the age of the dogs (&#8805;10 years; p=0.043) and the location of the police unit (p=0.016) with the urine culture.  Conclusion: The epidemiological characteristics of leptospirosis in dogs suggest an endemic presentation of the infection. There is an urgent need to improve current diagnostic methods to investigate canine leptospirosis and differentiate between vaccine and natural infection antibodies.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Leptospira]]></kwd>
<kwd lng="es"><![CDATA[estudios seroepidemiológicos]]></kwd>
<kwd lng="es"><![CDATA[pruebas de aglutinación]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[perros]]></kwd>
<kwd lng="en"><![CDATA[Leptospira]]></kwd>
<kwd lng="en"><![CDATA[seroepidemiologic studies]]></kwd>
<kwd lng="en"><![CDATA[agglutination tests]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
<kwd lng="en"><![CDATA[dogs]]></kwd>
</kwd-group>
</article-meta>
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