<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-4157</journal-id>
<journal-title><![CDATA[Biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Biomed.]]></abbrev-journal-title>
<issn>0120-4157</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-41572021000200338</article-id>
<article-id pub-id-type="doi">10.7705/biomedica.5407</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Streptococcus pneumoniae serotype 3 genotypes in invasive isolates from Colombia]]></article-title>
<article-title xml:lang="es"><![CDATA[Genotipos del serotipo 3 de Streptococcus pneumoniae en aislamientos invasivos en Colombia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alarcón]]></surname>
<given-names><![CDATA[Zonia Katerin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sanabria]]></surname>
<given-names><![CDATA[Olga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Salud  ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>41</volume>
<numero>2</numero>
<fpage>338</fpage>
<lpage>346</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-41572021000200338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-41572021000200338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-41572021000200338&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Streptococcus pneumoniae serotype 3 is an important cause of pneumonia, bacteremia, and meningitis.  Objective: To establish the circulating genotypes of S. pneumoniae serotype 3 isolates recovered from the invasive disease between 1994 to 2015 in Colombia.  Materials and methods: Of the 365 S. pneumoniae serotype 3 isolates recovered through the laboratory national surveillance program, 117 isolates were analyzed. Pulsed-field gel electrophoresis was used for genotyping, and multilocus sequence typing was determined in representative isolates.  Results: The frequency of this serotype increased from 2.7% between 1994 and 1998 to 9.1% between 2011 and 2015 (p=0.000); 91.7% of the isolates showed a genetic similarity greater than 77% and were related to the Netherlands3-31(PMEN31) clone CC180. Several subtypes were identified, two of which showed antimicrobial resistance.  Conclusion: In Colombia, the pneumococcal population of the capsular type 3 shows a continuous and homogeneous circulation relating to the clonal group ST-180.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. El serotipo 3 de Streptococcus pneumoniae es una causa importante de neumonía, bacteriemia y meningitis.  Objetivo. Establecer los genotipos circulantes de aislamientos del serotipo 3 de S. pneumoniae recuperados de muestras de enfermedad invasiva de 1994 a 2015 en Colombia.  Materiales y métodos. Se analizaron 117 de los 365 aislamientos del serotipo 3 de S. pneumoniae recuperados del programa nacional de vigilancia por el laboratorio. El genotipo se estableció con electroforesis en gel de campo pulsado y la tipificación se llevó a cabo mediante secuenciación multilocus en aislamientos representativos.  Resultados. La frecuencia de este serotipo aumentó de 2,7 % entre 1994 y 1998 a 9,1 % entre 2011 y 2015 (p=0,000). El 91,7 % de los aislamientos evidenció una similitud genética superior al 77 % y se relacionó con el clon CC180 de Netherlands3-31 (PMEN31). Se identificaron varios subtipos, dos de los cuales mostraron resistencia a los antimicrobianos.  Conclusión. En Colombia, la población neumocócica del tipo capsular 3 tiene una circulación continua y homogénea relacionada con el grupo clonal ST-180.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Streptococcus pneumoniae]]></kwd>
<kwd lng="en"><![CDATA[electrophoresis]]></kwd>
<kwd lng="en"><![CDATA[gel]]></kwd>
<kwd lng="en"><![CDATA[pulsed-field]]></kwd>
<kwd lng="en"><![CDATA[Colombia.]]></kwd>
<kwd lng="es"><![CDATA[Streptococcus pneumoniae]]></kwd>
<kwd lng="es"><![CDATA[Colombia]]></kwd>
<kwd lng="es"><![CDATA[electroforesis en gel de campo pulsado]]></kwd>
<kwd lng="es"><![CDATA[Colombia]]></kwd>
</kwd-group>
</article-meta>
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