<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-4157</journal-id>
<journal-title><![CDATA[Biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Biomed.]]></abbrev-journal-title>
<issn>0120-4157</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-41572021000400706</article-id>
<article-id pub-id-type="doi">10.7705/biomedica.5962</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Up-regulation of Arl4a gene expression by broccoli aqueous extract is associated with improved spermatogenesis in mouse testes]]></article-title>
<article-title xml:lang="es"><![CDATA[La regulación positiva de la expresión del gen Arl4a por acción del extracto acuoso de brócoli se asocia con una mejor espermatogénesis en testículos de ratón.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jazayeri]]></surname>
<given-names><![CDATA[Omid]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Araghi]]></surname>
<given-names><![CDATA[Setareh Farahmand]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aghajanzadeh]]></surname>
<given-names><![CDATA[Tahereh A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mohammadrezaei]]></surname>
<given-names><![CDATA[Fereshteh Mir]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of Mazandaran Faculty of Basic Science Department of Molecular and Cell Biology]]></institution>
<addr-line><![CDATA[Babolsar ]]></addr-line>
<country>Iran</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Mazandaran Faculty of Basic Science Department of Plant Sciences]]></institution>
<addr-line><![CDATA[Babolsar ]]></addr-line>
<country>Iran</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,University of Mazandaran Faculty of Basic Science Department of Animal Sciences]]></institution>
<addr-line><![CDATA[Babolsar ]]></addr-line>
<country>Iran</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>41</volume>
<numero>4</numero>
<fpage>706</fpage>
<lpage>720</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-41572021000400706&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-41572021000400706&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-41572021000400706&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Broccoli (Brassica oleracea) is well known for its properties as an anticancer, antioxidant, and scavenger of free radicals. However, its benefits in enhancing spermatogenesis have not been well established.  Objective: To study broccoli aqueous extract effects on sperm factors and the expression of genes Catsper1, Catsper2, Arl4a, Sox5, and Sox9 in sperm factors in mice.  Material and methods: Male mice were divided randomly into six groups: (1) Control; (2) cadmium (3 mg/kg of mouse body weight); (3) orally treated with 200 µl broccoli aqueous extract (1 g ml-1); (4) orally treated with 400 µl of broccoli aqueous extract; (5) orally treated with 200 broccoli aqueous extract plus cadmium, and (6) orally treated with 400 µl of broccoli aqueous extract plus cadmium. We analyzed the sperms factors and Catsper1, Catsper2, Arl4a, Sox5, and Sox9 gene expression.  Results: An obvious improvement in sperm count and a slight enhancement in sperm motility were observed in mice treated with broccoli extract alone or with cadmium. Sperm viability was reduced by broccoli extract except for the 200 µl dose with cadmium, which significantly increased it. Interestingly, Arl4a gene expression increased in the 400 µl broccoli- treated group. Likewise, the Arl4a mRNA level in mice treated with cadmium and 200 µl of broccoli extract was higher than in the cadmium-treated mice. Furthermore, broccoli extract enhanced the mRNA level of Catsper2 and Sox5 genes in mice treated with 200 µl and 400 µl broccoli extract plus cadmium compared with the group treated solely with cadmium.  Conclusion: The higher sperm count in broccoli-treated mice opens the way for the development of pharmaceutical products for infertile men.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. El brócoli (Brassica oleracea) se conoce por sus propiedades como anticancerígeno, antioxidante y eliminador de radicales libres. Sin embargo, sus beneficios en la espermatogénesis aún no se han determinado suficientemente.  Objetivo. Estudiar los efectos del extracto acuoso de brócoli sobre los factores espermáticos y la expresión de los genes Catsper1, Catsper2, Arl4a, Sox5 y Sox9 en ratones.  Materiales y métodos. Los ratones machos se dividieron aleatoriamente en seis grupos: 1) control; 2) tratados con cadmio, 3 mg/kg de peso corporal; 3) tratados con 200 µl de extracto acuoso de brócoli (1 g ml-1); 4) tratados con 400 µl de extracto acuoso de brócoli; 5) tratados con 200 µl de extracto acuoso de brócoli más cadmio, y 6) tratados con 400 µl de extracto acuoso de brócoli más cadmio. El extracto acuoso de brócoli se administró por vía oral. Se analizaron los factores espermáticos y la expresión de los genes Catsper1, Catsper2, Arl4a, Sox5 y Sox9.  Resultados. Se observó una mejoría obvia en el recuento y una ligera mejoría en la motilidad de los espermatozoides, en ratones tratados con extracto de brócoli solo o con cadmio. La viabilidad de los espermatozoides se redujo con el extracto de brócoli, excepto con la dosis de 200 µl más cadmio, la cual la aumentó significativamente. Curiosamente, la expresión del gen Arl4a aumentó en el grupo tratado con 400 µl del extracto. Asimismo, el ARNm del Arl4a en ratones tratados con cadmio y 200 µl del extracto, fue más abundante que en los ratones tratados solo con cadmio. Además, el extracto de brócoli aumentó la cantidad de ARNm de los genes Catsper2 y Sox5 en ratones tratados con 200 y 400 µl de extracto de brócoli más cadmio, en comparación con el grupo tratado únicamente con cadmio.  Conclusión. El mayor número de espermatozoides en ratones tratados con brócoli abre el camino al desarrollo de productos farmacéuticos para hombres infértiles.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Brassica]]></kwd>
<kwd lng="en"><![CDATA[spermatogenesis]]></kwd>
<kwd lng="en"><![CDATA[gene expression]]></kwd>
<kwd lng="en"><![CDATA[mice]]></kwd>
<kwd lng="en"><![CDATA[cadmium]]></kwd>
<kwd lng="es"><![CDATA[Brassica]]></kwd>
<kwd lng="es"><![CDATA[espermatogénesis]]></kwd>
<kwd lng="es"><![CDATA[expression génica]]></kwd>
<kwd lng="es"><![CDATA[ratones]]></kwd>
<kwd lng="es"><![CDATA[cadmio]]></kwd>
</kwd-group>
</article-meta>
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<page-range>79-87</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
