<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-548X</journal-id>
<journal-title><![CDATA[Acta Biológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta biol.Colomb.]]></abbrev-journal-title>
<issn>0120-548X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-548X2019000100026</article-id>
<article-id pub-id-type="doi">10.15446/abc.v24n1.69527</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[TRANSFORMING GROWTH FACTOR BETA HAS DUAL EFFECTS ON MMP9 AND uPA EXPRESSION IN HTR-8/SVneo HUMAN TROPHOBLASTIC CELL LINE]]></article-title>
<article-title xml:lang="es"><![CDATA[El factor de crecimiento transformante beta tiene efecto dual en la expresión de MMP9 y uPA en la línea celular de trofoblasto _HTR-8/SVneo]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[NOVOA HERRÁN]]></surname>
<given-names><![CDATA[Sandra Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[CASTELBLANCO]]></surname>
<given-names><![CDATA[Mariela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[SÁNCHEZ -GÓMEZ]]></surname>
<given-names><![CDATA[Myriam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[UMAÑA PÉREZ]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Ciencias Departamento de Química]]></institution>
<addr-line><![CDATA[Bogotá D.C ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>24</volume>
<numero>1</numero>
<fpage>26</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-548X2019000100026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-548X2019000100026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-548X2019000100026&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Invasion of trophoblast into endometrium is vital for successful pregnancy development. MMP9 and uPA are key proteases in this process, but it is still not clear the regulation of its expression by Transforming Growth Factor Beta (TGF-&#946;), a known negative regulator of trophoblast invasion. We evaluated the effect of TGF-&#946; on the transcriptional expression of uPA and MMP9 over time, in HTR-8/SVneo trophoblast cells cultured with or without 0.5 % fetal bovine serum, via RT qPCR. The involved transcription factors and signaling pathways were analyzed in silico, using Proscan, Enrich, PCViz and Wiki Pathway. Results showed that TGF-&#946; temporarily regulates the expression of uPA and MMP9. Serum modified the nature of TGF-&#946;'s effects on uPA expression, from negative without serum to positive with it, showing opposite effects on MMP9 expression. In silico analysis evidenced different transcription factors for each protease, some belonging to TGF-&#946; signaling pathway, and crosstalk with MAPK and Wnt/&#946; -catenin pathways. The TGF-&#946; dual role is discussed proposing that serum affects the cellular context. Transcriptional regulation of MMP9 and uPA by TGF-&#946; is differential and depends on serum presence and evaluation time.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La invasión del trofoblasto al endometrio es vital para el correcto desarrollo del embarazo. Las proteasas MMP9 y uPA son claves en este proceso, pero aún no es clara la regulación de su expresión por parte del Factor de Crecimiento Transformante beta (TGF-&#946;), conocido por sus acciones no invasivas sobre el trofoblasto. En este trabajo evaluamos el efecto del TGF-&#946; sobre la expresión transcripcional de uPA y MMP9 en células de la línea de trofoblasto HTR-8/SVneo cultivadas con o sin suero fetal bovino al 0,5 %, mediante RT qPCR. Se analizaron in sillico los potenciales factores de transcripción y vías de señalización involucradas empleando Proscan, Enrich, PCViz y WikiPathway. Los resultados muestran que el TGF-&#946; regula temporalmente la expresión de uPA y MMP9. El suero modificó la naturaleza del efecto del TGF-&#946; sobre la expresión de uPA, de negativo en ausencia de suero a positivo en presencia de este, presentando efectos opuestos para la expresión de MMP9. El análisis in sillico evidenció diferentes factores de transcripción para cada proteasa, algunos pertenecientes a la vía de señalización del TGF-&#946;, y un entrecruzamiento con la vía MAPK y Wnt/&#946;-catenina. Los resultados sugieren que la regulación transcripcional de MMP9 y uPA por parte del TGF-&#946; es diferencial y depende de la presencia de suero y tiempo de evaluación.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Computational biology]]></kwd>
<kwd lng="en"><![CDATA[matrix metalloproteinase]]></kwd>
<kwd lng="en"><![CDATA[placenta]]></kwd>
<kwd lng="en"><![CDATA[plasminogen]]></kwd>
<kwd lng="en"><![CDATA[polymerase chain reaction]]></kwd>
<kwd lng="es"><![CDATA[Biología computacional]]></kwd>
<kwd lng="es"><![CDATA[metaloproteinasa de matrix]]></kwd>
<kwd lng="es"><![CDATA[placenta]]></kwd>
<kwd lng="es"><![CDATA[plasminógeno]]></kwd>
<kwd lng="es"><![CDATA[reacción en cadena polimerasa]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Belkacemi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lash]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
<name>
<surname><![CDATA[Macdonald-Goodfellow]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Caldwell]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Graham]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of human trophoblast invasiveness by high glucose concentrations]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2005</year>
<volume>90</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>4846-51</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cerami]]></surname>
<given-names><![CDATA[EG]]></given-names>
</name>
<name>
<surname><![CDATA[Gross]]></surname>
<given-names><![CDATA[BE]]></given-names>
</name>
<name>
<surname><![CDATA[Demir]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rodchenkov]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Babur]]></surname>
<given-names><![CDATA[Ö]]></given-names>
</name>
<name>
<surname><![CDATA[Anwar]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathway Commons, a web resource for biological pathway data]]></article-title>
<source><![CDATA[Nucleic Acids Res]]></source>
<year>2011</year>
<volume>39</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>D685-90</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Meisser]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bischof]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metalloproteinases and Human Placental Invasiveness]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>2006</year>
<volume>27</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>783-93</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gleeson]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[McKinnon]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Lala]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation of human trophoblast migration and invasiveness]]></article-title>
<source><![CDATA[Can.J. Physiol. Pharmacol]]></source>
<year>2002</year>
<volume>80</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>116-24</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[EY]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Kou]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Duan]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Meirelles]]></surname>
<given-names><![CDATA[GV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool]]></article-title>
<source><![CDATA[BMC bioinformatics]]></source>
<year>2013</year>
<volume>14</volume>
<page-range>128</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[J-C]]></given-names>
</name>
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[H-M]]></given-names>
</name>
<name>
<surname><![CDATA[Leung]]></surname>
<given-names><![CDATA[PCK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[TGF-&#946;1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation]]></article-title>
<source><![CDATA[Cell Signal]]></source>
<year>2018</year>
<volume>43</volume>
<page-range>55-61</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferretti]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bruni]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Dangles-Marie]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Pecking]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Bellet]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts]]></article-title>
<source><![CDATA[Hum Reprod Update]]></source>
<year>2007</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>121-41</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Friedl]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tumour-cell invasion and migration: diversity and escape mechanisms]]></article-title>
<source><![CDATA[Nat Rev Cancer]]></source>
<year>2003</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>362-74</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Graham]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Hawley]]></surname>
<given-names><![CDATA[TS]]></given-names>
</name>
<name>
<surname><![CDATA[Hawley]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[MacDougall]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Kerbel]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Khoo]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan]]></article-title>
<source><![CDATA[Exp Cell Res]]></source>
<year>1993</year>
<volume>206</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>204-11</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[van Iperen]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[de Jong]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Szuhai]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Helmerhorst]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[van der Westerlaken]]></surname>
<given-names><![CDATA[LAJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human Extravillous Trophoblasts Penetrate Decidual Veins and Lymphatics before Remodeling Spiral Arteries during Early Pregnancy]]></article-title>
<source><![CDATA[PLOS ONE]]></source>
<year>2017</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hellemans]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mortier]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[De Paepe]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Speleman]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Vandesompele]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data]]></article-title>
<source><![CDATA[Genome Biol]]></source>
<year>2007</year>
<volume>8</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>R19</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transforming growth factor beta1 promotes invasion of human JEG-3 trophoblast cells via TGF-beta/Smad3 signaling pathway]]></article-title>
<source><![CDATA[Oncotarget]]></source>
<year>2017</year>
<volume>8</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>33560-70</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ikushima]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Miyazono]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[TGF&#946; signalling: a complex web in cancer progression]]></article-title>
<source><![CDATA[Nat Rev Cancer]]></source>
<year>2010</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>415-24</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karmakar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Das]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation ofTrophoblast Invasion by IL-1&#946; and TGF-&#946;1]]></article-title>
<source><![CDATA[AmJ Of Reprod Immunol]]></source>
<year>2002</year>
<volume>48</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>210-9</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kholodenko]]></surname>
<given-names><![CDATA[BN]]></given-names>
</name>
<name>
<surname><![CDATA[Hancock]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Kolch]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Signalling ballet in space and time]]></article-title>
<source><![CDATA[Nat Rev Mol Cell Biol]]></source>
<year>2010</year>
<volume>11</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>414-26</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kutmon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lotia]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Evelo]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
<name>
<surname><![CDATA[Pico]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<source><![CDATA[WikiPathways App for Cytoscape: Making biological pathways amenable to network analysis and visualization]]></source>
<year>2014</year>
<volume>3</volume>
<page-range>152</page-range><publisher-name><![CDATA[F1000Res]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lala]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Graham]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Lysiak]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Khoo]]></surname>
<given-names><![CDATA[NKS]]></given-names>
</name>
<name>
<surname><![CDATA[Hamilton]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[TGF&#946; regulation of trophoblast function]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>1998</year>
<volume>19</volume>
<page-range>149-57</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lala]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[BP]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human placental trophoblast as an in vitro model for tumor progression]]></article-title>
<source><![CDATA[Can.J. Physiol. Pharmacol]]></source>
<year>2002</year>
<volume>80</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>142-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lala]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factors Regulating Trophoblast Migration and Invasiveness: Possible Derangements Contributing to Pre-eclampsia and Fetal Injury]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>2003</year>
<volume>24</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>575-87</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lash]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
<name>
<surname><![CDATA[Otun]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Innes]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Bulmer]]></surname>
<given-names><![CDATA[JN]]></given-names>
</name>
<name>
<surname><![CDATA[Searle]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
<name>
<surname><![CDATA[Robson]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases]]></article-title>
<source><![CDATA[Biol Reprod]]></source>
<year>2005</year>
<volume>73</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>374-81</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[DQ]]></given-names>
</name>
<name>
<surname><![CDATA[Shao]]></surname>
<given-names><![CDATA[ZM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chapter 19 - Emerging Therapeutic Targets for Cancer Metastasis: From the Perspective of Embryo Implantation]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Introduction to Cancer Metastasis]]></source>
<year>2017</year>
<page-range>353-73</page-range><publisher-loc><![CDATA[Ciudad ]]></publisher-loc>
<publisher-name><![CDATA[Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[HY]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
<name>
<surname><![CDATA[Qi]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[HX]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Involvement ofSMAD4, but not ofSMAD2, in transforming growth factor-beta1-induced trophoblast expression of matrix metalloproteinase-2]]></article-title>
<source><![CDATA[Front Biosci]]></source>
<year>2006</year>
<volume>11</volume>
<page-range>637-46</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Dang]]></surname>
<given-names><![CDATA[Y-L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta]]></article-title>
<source><![CDATA[Cell Res]]></source>
<year>2018</year>
<volume>28</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>819-32</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lunghi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ferretti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Medici]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Biondi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Vesce]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Control of human trophoblast function]]></article-title>
<source><![CDATA[Reprod Biol Endocrinol]]></source>
<year>2007</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>6</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahmood]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Mihalcioiu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Rabbani]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications]]></article-title>
<source><![CDATA[Front Oncol]]></source>
<year>2018</year>
<volume>8</volume>
<numero>24</numero>
<issue>24</issue>
</nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mandl]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Haas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bischof]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Nohammer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Desoye]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum-dependent effects of IGF-I and insulin on proliferation and invasion of human first trimester trophoblast cell models]]></article-title>
<source><![CDATA[Histochem Cell Biol]]></source>
<year>2002</year>
<volume>117</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>391-9</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meisser]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chardonnens]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Campana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bischof]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of tumour necrosis factor-&#946;, interleukin-1&#946;, macrophage colony stimulating factor and transforming growth factor &#946; ( on trophoblastic matrix metalloproteinases]]></article-title>
<source><![CDATA[Mol Hum Reprod]]></source>
<year>1999</year>
<volume>5</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>252-60</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menkhorst]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Winship]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Van Sinderen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Dimitriadis]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human extravillous trophoblast invasion: intrinsic and extrinsic regulation]]></article-title>
<source><![CDATA[Reprod Fertil Dev]]></source>
<year>2016</year>
<volume>28</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>406-15</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Novoa-Herran]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Umaña-Perez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Canals]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sanchez-Gomez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo]]></article-title>
<source><![CDATA[Cell Mol Biol Lett]]></source>
<year>2016</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>22</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pang]]></surname>
<given-names><![CDATA[Z-J]]></given-names>
</name>
<name>
<surname><![CDATA[Xing]]></surname>
<given-names><![CDATA[F-Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression of transforming growth factor-&#946; and insulin-like growth factor in molar and placental tissues]]></article-title>
<source><![CDATA[Arch Gynecol Obstet]]></source>
<year>2003</year>
<volume>269</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-4</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pardali]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Moustakas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actions of TGF-[beta] as tumor suppressor and pro-metastatic factor in human cancer]]></article-title>
<source><![CDATA[Biochim Biophys Acta Rev Cancer]]></source>
<year>2007</year>
<volume>1775</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-62</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pollheimer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Knöfler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Signalling pathways regulating the invasive differentiation of human trophoblasts: a review]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>2005</year>
<volume>26</volume>
<page-range>21-30</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shannon]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Markiel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ozier]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Baliga]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Ramage]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks]]></article-title>
<source><![CDATA[Genome Res]]></source>
<year>2003</year>
<volume>13</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2498-504</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shimonovitz S]]></surname>
<given-names><![CDATA[HurwitzA]]></given-names>
</name>
<name>
<surname><![CDATA[BarakV]]></surname>
<given-names><![CDATA[Dushnik M]]></given-names>
</name>
<name>
<surname><![CDATA[Adashi EY]]></surname>
<given-names><![CDATA[Anteby E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cytokine-mediated regulation of type IV collagenase expression and production in human trophoblast cells]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>1996</year>
<volume>81</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>3091-6</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Staun-Ram]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Goldman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gabarin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Shalev]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion]]></article-title>
<source><![CDATA[Reprod Biol Endocrinol]]></source>
<year>2004</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Turunen]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
<name>
<surname><![CDATA[Tatti-Bugaeva]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Lehti]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Membrane-type matrix metalloproteases as diverse effectors of cancer progression]]></article-title>
<source><![CDATA[Biochim Biophys Acta Mol Cell Res]]></source>
<year>2017</year>
<volume>1864</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1974-88</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weber]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Knoefler]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Schleussner]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Markert]]></surname>
<given-names><![CDATA[UR]]></given-names>
</name>
<name>
<surname><![CDATA[Fitzgerald]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[HTR8/SVneo Cells Display Trophoblast Progenitor Cell-Like Characteristics Indicative of Self-Renewal, Repopulation Activity, and Expression of "Sternness-"; Associated Transcription Factors]]></article-title>
<source><![CDATA[Bio Med Res Int]]></source>
<year>2013</year>
<volume>2013</volume>
<page-range>10</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yanzhen]]></surname>
<given-names><![CDATA[ZUO]]></given-names>
</name>
<name>
<surname><![CDATA[Zhihua]]></surname>
<given-names><![CDATA[FU]]></given-names>
</name>
<name>
<surname><![CDATA[Yatao]]></surname>
<given-names><![CDATA[HU]]></given-names>
</name>
<name>
<surname><![CDATA[Yuhong]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
<name>
<surname><![CDATA[Qian]]></surname>
<given-names><![CDATA[XU]]></given-names>
</name>
<name>
<surname><![CDATA[Dayong]]></surname>
<given-names><![CDATA[SUN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of transforming growth factor-&#946; 1 on the proliferation and invasion of the HTR-8/SVneo cell line]]></article-title>
<source><![CDATA[Oncol Lett]]></source>
<year>2014</year>
<volume>8</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>2187-92</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[ChengJ]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Klausen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Leung]]></surname>
<given-names><![CDATA[PCK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[TGF-beta1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2]]></article-title>
<source><![CDATA[Placenta]]></source>
<year>2018</year>
<volume>68</volume>
<page-range>44-51</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yudate]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Isaka]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kosugi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Koshiishi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Shiraishi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hosaka]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of the mechanism of trophoblast infiltration]]></article-title>
<source><![CDATA[Nihon Sanka Fujinka Gakkai Zasshi]]></source>
<year>1996</year>
<volume>48</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>191-8</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[S-M]]></given-names>
</name>
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[F-J]]></given-names>
</name>
<name>
<surname><![CDATA[Zeng]]></surname>
<given-names><![CDATA[W-H]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[X-L]]></given-names>
</name>
<name>
<surname><![CDATA[Ren]]></surname>
<given-names><![CDATA[J-B]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[XCL1-XCR1 pathway promotes trophoblast invasion at maternal-fetal interface by inducing MMP-2/MMP-9 activity]]></article-title>
<source><![CDATA[Am J Of Reprod Immunol]]></source>
<year>2018</year>
<volume>80</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[M-r]]></given-names>
</name>
<name>
<surname><![CDATA[Qiu]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y-x]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z-b]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y-l]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dual effect of transforming growth factor (1 on cell adhesion and invasion in human placenta trophoblast cells]]></article-title>
<source><![CDATA[Reproduction]]></source>
<year>2006</year>
<volume>132</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>333-41</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Yan]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[AP1 mediates uPA/ uPAR induced FUT4 expression and trophoblast invasion]]></article-title>
<source><![CDATA[J Cell Biochem]]></source>
<year>2018</year>
<volume>119</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>6442-51</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
