<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-548X</journal-id>
<journal-title><![CDATA[Acta Biológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta biol.Colomb.]]></abbrev-journal-title>
<issn>0120-548X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-548X2020000200294</article-id>
<article-id pub-id-type="doi">10.15446/abc.v25n2.77407</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[ANTIMICROBIAL PEPTIDES, AN ALTERNATIVE TO COMBAT BACTERIAL RESISTANCE]]></article-title>
<article-title xml:lang="es"><![CDATA[Péptidos antimicrobianos, una alternativa para el combate de la resistencia bacteriana]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[MEJÍA-ARGUETA]]></surname>
<given-names><![CDATA[Euridice Ladisu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[SANTILLÁN-BENÍTEZ]]></surname>
<given-names><![CDATA[Jonnathan Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[ORTIZ-REYNOSO]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Autonomous University of the State of Mexico Faculty of Chemistry ]]></institution>
<addr-line><![CDATA[Ciprés Toluca]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Autonomous University of the State of Mexico Faculty of Chemistry ]]></institution>
<addr-line><![CDATA[Toluca ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Autonomous University of the State of Mexico Faculty of Chemistry ]]></institution>
<addr-line><![CDATA[Toluca ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<fpage>294</fpage>
<lpage>302</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-548X2020000200294&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-548X2020000200294&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-548X2020000200294&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Antimicrobial peptides (AMPs) of higher organisms have been studied for the past 25 years, and their importance as components of innate immunity is now well established. The essential simplicity of their chemical structure, along with the lower likelihood of developed resistance compared to conventional antibiotics, has made them attractive candidates for development as therapeutics. The objective of this review article is to describe the current relevance, main mechanisms presented, and the uses of antimicrobial peptides as new therapies in the clinical area. The information used was mainly compiled from scientific articles based on a systematic review of scientific papers with data on human AMPs and their different applications, searching without date limits and only documents in English and Spanish. Gray literature was excluded, and no restrictions were made involving study design for a retrospective study. Although these products have not yet been commercialized, they have advantages over the currently available treatments since they are not expected to cause bacterial resistance due to their three-dimensional structure, amphipathic tendency, and cationic character; however, the technique of peptide production is still new and is in the early stages of innovation of new molecules.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los péptidos antimicrobianos (AMPs) de organismos superiores se han estudiado durante los últimos 25 años y su importancia como componentes de la inmunidad innata está ahora bien establecida. La simplicidad básica de la estructura química de los péptidos antimicrobianos, junto con la menor probabilidad de aparición de resistencia en comparación con los antibióticos convencionales, los ha convertido en candidatos atractivos para el desarrollo como terapéuticos. El objetivo de este artículo de revisión es describir su relevancia actual, los mecanismos principales que presentan y los usos que se les están dando como nuevas terapias en la clínica. La información usada se recopiló principalmente de artículos científicos con datos sobre AMPs humanos y sus diferentes aplicaciones. Aunque aún no se comercialicen estos productos, tienen ventajas sobre los tratamientos existentes, puesto que se prevé que no causen resistencia bacteriana, esto debido a su estructura tridimensional, su tendencia anfipática y su carácter catiónico. Aunque la técnica de producción de péptidos es aún nueva y está en las primeras etapas de innovación de nuevas moléculas, promete importantes logros en un futuro cercano en el diseño de péptidos más eficientes o que sean estables en diferentes ambientes.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Antimicrobial potential]]></kwd>
<kwd lng="en"><![CDATA[immune system]]></kwd>
<kwd lng="en"><![CDATA[therapeutic agents]]></kwd>
<kwd lng="es"><![CDATA[Agentes terapéuticos]]></kwd>
<kwd lng="es"><![CDATA[potencial antimicrobiano]]></kwd>
<kwd lng="es"><![CDATA[sistema inmunológico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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