<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5633</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Colomb. Cardiol.]]></abbrev-journal-title>
<issn>0120-5633</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Colombiana de Cardiologia. Oficina de Publicaciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-56332016000500403</article-id>
<article-id pub-id-type="doi">10.1016/j.rccar.2016.06.009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Isquemia miocárdica: conceptos básicos, diagnóstico e implicaciones clínicas. Primera parte]]></article-title>
<article-title xml:lang="en"><![CDATA[Myocardial ischaemia: basic concepts, diagnosis and clinical implications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[Pedro R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Portillo]]></surname>
<given-names><![CDATA[Juan H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Icahn School of Medicine at Mount Sinai  ]]></institution>
<addr-line><![CDATA[New York ]]></addr-line>
<country>Estados Unidos</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Santa Fe de Bogotá Cardiología ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>23</volume>
<numero>5</numero>
<fpage>403</fpage>
<lpage>409</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-56332016000500403&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-56332016000500403&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-56332016000500403&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La isquemia miocárdica es el conjunto de una serie de fenómenos fisiológicos que se manifiesta por condiciones clínicas como isquemia silente, angina estable y síndromes corona-rios agudos. Diversos mecanismos de la regulación del flujo sanguíneo, la demanda miocárdica, la liberación de adenosina y la función del endotelio en las arterias coronarias son claves para mantener la irrigación miocárdica y han sido la base fisiológica para el desarrollo de pruebas de detección de isquemia como lo es el flujo de reserva fraccional, que hoy día hace parte de las recomendaciones de las guías.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Myocardial ischaemia as a whole is a series of physiological phenomena manifested by clinical conditions such as silent ischaemia, stable angina and acute coronary syndromes. Various blood flow regulation mechanisms, myocardial demand, adenosine release and endot-helial function in the coronary arteries are vital for maintaining myocardial irrigation, and have been the physiological basis for tests like fractional flow reserve, developed to detect ischaemia, that today forms part of the guideline recommendations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad]]></kwd>
<kwd lng="es"><![CDATA[coronaria]]></kwd>
<kwd lng="es"><![CDATA[Isquemia]]></kwd>
<kwd lng="es"><![CDATA[Cardiopatía]]></kwd>
<kwd lng="es"><![CDATA[isquémica]]></kwd>
<kwd lng="es"><![CDATA[Hibernación]]></kwd>
<kwd lng="es"><![CDATA[Flujo sanguíneo]]></kwd>
<kwd lng="en"><![CDATA[Coronary heart]]></kwd>
<kwd lng="en"><![CDATA[disease]]></kwd>
<kwd lng="en"><![CDATA[Ischaemia]]></kwd>
<kwd lng="en"><![CDATA[Ischaemic]]></kwd>
<kwd lng="en"><![CDATA[cardiopathy]]></kwd>
<kwd lng="en"><![CDATA[Hibernation]]></kwd>
<kwd lng="en"><![CDATA[Blood flow]]></kwd>
</kwd-group>
</article-meta>
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