<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5633</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Colomb. Cardiol.]]></abbrev-journal-title>
<issn>0120-5633</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Colombiana de Cardiologia. Oficina de Publicaciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-56332021000300246</article-id>
<article-id pub-id-type="doi">10.24875/rccar.m21000057</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre mortalidad y tratamiento recibido en pacientes con endocarditis infecciosa]]></article-title>
<article-title xml:lang="en"><![CDATA[Relationship between mortality and treatment received in patients with infective endocarditis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Mesa]]></surname>
<given-names><![CDATA[Juan E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calderón-Miranda]]></surname>
<given-names><![CDATA[Camilo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romo-Escorcia]]></surname>
<given-names><![CDATA[Camilo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galindo-Coral]]></surname>
<given-names><![CDATA[Stephania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-Suárez]]></surname>
<given-names><![CDATA[Angy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moncada-Vallejo]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Valle del Lili Servicio de Cardiología y Falla Cardíaca ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Valle del Lili Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle Departamento de Epidemiología ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fundación Valle del Lili Servicio de Infectología ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<numero>3</numero>
<fpage>246</fpage>
<lpage>253</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-56332021000300246&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-56332021000300246&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-56332021000300246&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La endocarditis infecciosa es una enfermedad de baja incidencia y alta morbilidad. Puede tener un curso agudo o subagudo, con complicaciones que están directamente relacionadas con la mortalidad y varían según el agente infeccioso; el más frecuente es Staphylococcus aureus. Dependiendo de la condición clínica se puede elegir una terapia antimicrobiana exclusiva o una terapia combinada (antimicrobiana y cirugía); la elección adecuada impacta en las tasas de sobrevida.  Objetivo: Describir las características clínicas, microbiológicas y ecocardiográficas en pacientes con endocarditis infecciosa y analizar la mortalidad según el tratamiento recibido (terapia antimicrobiana o terapia combinada).  Método: Estudio de cohorte retrospectivo, realizado en el Hospital Universitario Fundación Valle del Lili, en Cali, Colombia, en el que se incluyeron pacientes hospitalizados mayores de 18 años que cumplían los criterios de Duke modificados para diagnóstico de endocarditis infecciosa. Se evaluaron dos cohortes según hubieran recibido tratamiento antimicrobiano exclusivo o terapia combinada. Los pacientes fueron seguidos hasta el egreso hospitalario.  Resultados: De 101 pacientes, 58 recibieron terapia antimicrobiana y 43 terapia combinada. La sobrevida global fue del 77.35%; el grupo de terapia combinada tuvo una hazard ratio ajustada de 0.13 (intervalo de confianza del 95%: 0.036-0.505; p = 0.003). La tasa de mortalidad calculada por 1000 días-persona fue de 25.9 con terapia antimicrobiana y de 4.33 con terapia combinada.  Conclusiones: El grupo de terapia combinada tuvo más complicaciones y mayor estancia en la unidad de cuidados intensivos, pero menores tasas de mortalidad que los pacientes con terapia antimicrobiana exclusiva. De acuerdo con las indicaciones actuales de manejo quirúrgico descritas en las guías internacionales, se pueden obtener excelentes resultados en los pacientes más enfermos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Infective endocarditis is a disease of low incidence but high morbidity. It can have an acute or subacute course, with complications that are directly related to mortality and vary according to the infectious agent; the most common is Staphylococcus aureus. Based on the clinical condition, an exclusive antimicrobial therapy or a combined therapy (antimicrobial and surgery) can be chosen; their proper choice impacts survival rates.  Objective: To describe the clinical, microbiological and echocardiographic characteristics in patients with infective endocarditis and to analyze how mortality behaved according to the treatment received (antimicrobial therapy or combined therapy).  Method: A retrospective cohort study, carried out at the Fundación Valle del Lili University Hospital, Cali, Colombia, which included hospitalized patients over 18 years of age who met modified Duke criteria for the diagnosis of infective endocarditis. Two cohorts were evaluated according to treatment: exclusive antimicrobial and combined therapy. They were followed until discharge from the hospital.  Results: Of 101 patients, 58 received antimicrobial therapy and 43 combined therapy. Overall survival was 77.35%, the combined therapy group had an adjusted hazard ratio of 0.13 (95% confidence interval: 0.036-0.505; p = 0.003). The mortality rate calculated per 1000 person-days was 25.9 in antimicrobial therapy and 4.33 in combination therapy.  Conclusions: the combined therapy group had more complications and a longer hospital stay in the ICU, but lower mortality rates than the patients on exclusive antimicrobial therapy. According to the current indications for surgical management described in international guidelines, excellent results can be obtained in sicker patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Endocarditis]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Cirugía]]></kwd>
<kwd lng="es"><![CDATA[Falla cardiaca]]></kwd>
<kwd lng="en"><![CDATA[Endocarditis]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Surgery]]></kwd>
<kwd lng="en"><![CDATA[Heart failure]]></kwd>
</kwd-group>
</article-meta>
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