<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5633</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Colomb. Cardiol.]]></abbrev-journal-title>
<issn>0120-5633</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Colombiana de Cardiologia. Oficina de Publicaciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-56332022000100016</article-id>
<article-id pub-id-type="doi">10.24875/rccar.m22000112</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Otto Frank y Ernest Starling. Más allá de una ley o un mecanismo. Breve reseña histórica]]></article-title>
<article-title xml:lang="en"><![CDATA[Otto Frank and Ernest Starling. Beyond a law or a mechanism. Brief historical relate]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Donoso-Fuentes]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arriagada-Santis]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Dra. Eloísa Diaz I., La Florida Unidad de Paciente Crítico Pediátric ]]></institution>
<addr-line><![CDATA[Santiago ]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>16</fpage>
<lpage>22</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-56332022000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-56332022000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-56332022000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La ley o mecanismo de Frank-Starling describe la relación entre la longitud inicial de las fibras miocárdicas y la fuerza generada por su poder de contracción. Aunque ni Otto Frank (1895) como tampoco Ernest Starling (1915) fueron los primeros en descubrir que el volumen diastólico final regula el trabajo del corazón, su participación para este famoso epónimo fisiológico es indiscutible, y de ahí que sus nombres perduraran por más de un siglo en el ambiente de la fisiología, la cardiología y los cuidados intensivos, entre otras disciplinas. Se revisa la biografía de Otto Frank (1865-1944), un excepcional fisiólogo alemán con un amplio conocimiento en física, matemáticas y ciencias naturales, que formuló principios teóricos para la fisiología muscular y cardiovascular, además de muchas otras contribuciones metodológicas e instrumentales. También se examina la vida del gran médico y fisiólogo inglés Ernest Henry Starling (1866-1927), quien elaboró diversos y relevantes aportes científicos, más allá de sus afamadas publicaciones sobre la función circulatoria. Finalmente, el presente artículo comenta en forma breve sus principales y más importantes contribuciones, así como también aspectos menos conocidos de sus logros científicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Frank-Starling&#8217;s law or mechanism describes the relationship between the initial length of myocardial fibers and the force generated by their contraction power. Although neither Otto Frank (1895) nor Ernest Starling (1915) were the first to discover that the final diastolic volume regulates the work of the heart, their participation for this famous physiological eponym is indisputable, enduring their names for more than a century in the environment of physiology, cardiology and intensive care, among other disciplines. The biography of Otto Frank (1865-1944) is reviewed, who was an exceptional German physiologist with extensive knowledge in physics, mathematics and natural sciences who formulated theoretical principles for muscular and cardiovascular physiology, in addition to many other methodological contributions in instrumentals. Also examined the life of the great English physician and physiologist Ernest Henry Starling (1866-1927), who produced various and relevant scientific contributions, beyond his famous publications on circulatory function. Finally, this article briefly comments on its main and most important contributions, as well as less known aspects of its scientific achievements.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fisiología]]></kwd>
<kwd lng="es"><![CDATA[Corazón]]></kwd>
<kwd lng="es"><![CDATA[Ley de Frank-Starling]]></kwd>
<kwd lng="es"><![CDATA[Biografía]]></kwd>
<kwd lng="es"><![CDATA[Historia de la medicina]]></kwd>
<kwd lng="en"><![CDATA[Physiology]]></kwd>
<kwd lng="en"><![CDATA[Heart]]></kwd>
<kwd lng="en"><![CDATA[Frank-Starling law]]></kwd>
<kwd lng="en"><![CDATA[Biography]]></kwd>
<kwd lng="en"><![CDATA[Medicine history]]></kwd>
</kwd-group>
</article-meta>
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