<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8705</journal-id>
<journal-title><![CDATA[CES Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[CES Med.]]></abbrev-journal-title>
<issn>0120-8705</issn>
<publisher>
<publisher-name><![CDATA[Universidad CES]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87052020000100083</article-id>
<article-id pub-id-type="doi">10.21615/cesmedicina.34.1.8</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Linfoma intravascular de células B grandes con afección cerebral]]></article-title>
<article-title xml:lang="en"><![CDATA[Intravascular large b-cell Lymphoma with cerebral involvement]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mayner-Tresol]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Villasmil]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Católica de Santiago de Guayaquil  ]]></institution>
<addr-line><![CDATA[Guayaquil ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Central &#8220;Dr. Urquinaona&#8221;  ]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2020</year>
</pub-date>
<volume>34</volume>
<numero>1</numero>
<fpage>83</fpage>
<lpage>89</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87052020000100083&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87052020000100083&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87052020000100083&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El linfoma intravascular de células B grandes es una rara variante del linfoma no Hodgkin que se caracteriza por proliferación clonal de células linfoides neoplásicas que crecen dentro de la luz de la microvasculatura. La diversidad de su presentación clínica dada su posibilidad de aparición en cualquier órgano, a menudo lo convierte en un diagnóstico difícil. El espectro clínico es heterogéneo dominado por manifestaciones neurológicas y puede pasarse por alto o diagnosticarse erróneamente. El diagnóstico sigue siendo un reto, ya que no existen hallazgos patognomónicos de neuroimágenes y aún no se ha establecido un tratamiento óptimo. Presentamos el caso de una mujer de 38 años con linfoma intravascular de células B grandes con afección cerebral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Intravascular large B-cell lymphoma is a rare variant of non-Hodgkin lym- phoma characterized by clonal proliferation of neoplastic lymphoid cells that grow within lumen of the microvasculature. The diversity of the clinical presentation due to the possibility of its appearance in any organ often makes it a difficult diagnosis. Clinical spectrum is heterogeneous, dominated by neurological manifestations can be overlooked or misdiagnosed. Diagnosis remains a challenge, since there are no pathognomonic neuroimaging findings and optimal treatment has not yet been established. We present a 38-year-old female patient with intravascular large B-cell lymphoma with cerebral involvement.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Linfoma intravascular de células B grandes]]></kwd>
<kwd lng="es"><![CDATA[Linfoma no Hodgkin]]></kwd>
<kwd lng="es"><![CDATA[Linfoma]]></kwd>
<kwd lng="es"><![CDATA[Células B]]></kwd>
<kwd lng="es"><![CDATA[Sistema nervioso central.]]></kwd>
<kwd lng="en"><![CDATA[Intravascular large B-cell lymphoma]]></kwd>
<kwd lng="en"><![CDATA[Non-Hodgkin lymphoma]]></kwd>
<kwd lng="en"><![CDATA[lymphoma]]></kwd>
<kwd lng="en"><![CDATA[B-cell]]></kwd>
<kwd lng="en"><![CDATA[Central nervous system.]]></kwd>
</kwd-group>
</article-meta>
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