<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8705</journal-id>
<journal-title><![CDATA[CES Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[CES Med.]]></abbrev-journal-title>
<issn>0120-8705</issn>
<publisher>
<publisher-name><![CDATA[Universidad CES]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87052023000100029</article-id>
<article-id pub-id-type="doi">10.21615/cesmedicina.6936</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desenlaces materno-perinatales en pacientes tratadas con terapia antimicrobiana por sospecha de infección inflamación intraamniótica subclínica]]></article-title>
<article-title xml:lang="en"><![CDATA[Maternal and perinatal clinical outcomes among patients treated with antimicrobials for suspected subclinical intra-amniotic inflammation/ infection]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardozo Buitrago]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Torres]]></surname>
<given-names><![CDATA[Luisa Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias Muñoz]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campo]]></surname>
<given-names><![CDATA[María Nazareth Campo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Marín]]></surname>
<given-names><![CDATA[Jorge Hernán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[SanínBlair]]></surname>
<given-names><![CDATA[José Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuesta Castro]]></surname>
<given-names><![CDATA[Diana Paola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Pontificia Bolivariana  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Pontificia Bolivariana  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Pontificia Bolivariana  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>29</fpage>
<lpage>43</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87052023000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87052023000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87052023000100029&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  el parto pretérmino es una importante causa de morbimortalidad perinatal; entre las principales etiologías está la infección inflamación intraamniótica que se asocia a resultados perinatales adversos. El objetivo del presente estudio fue evaluar la asociación de la antibioticoterapia con los desenlaces maternos, fetales y perinatales en gestantes con sospecha de infección intraamniótica en un centro de alta complejidad obstétrica.  Métodos:  estudio analítico de cohortes ambispectivo en gestantes con embarazo simple con edad gestacional &#8805; 24 semanas atendidas en la Clínica Universitaria Bolivariana (CUB) con sospecha diagnóstica de infección/inflamación intramniótica subclínica desde enero del 2011 a diciembre del 2021. Se evaluó la asociación entre el uso de antimicrobianos y los desenlaces clínicos materno y perinatales.  Resultados:  entre los hallazgos clínicos, ecográficos y paraclínicos se destacó el dolor abdominal, sangrado y la presencia de sludge en la cervicometría. La prevalencia del uso de antimicrobianos entre quienes tenían sludge fue 1,88 veces comparado con quienes no tenían este hallazgo ecográfico, (IC95% 1,23- 2,88), p 0,0009; mientras que la de la dinámica uterina fue 1,43 veces (IC95% 1,06- 1,94), p 0,050. La diferencia de medianas de los leucocitos en líquido amniótico reportó un exceso del número de leucocitos por campo entre las que recibieron antimicrobianos, diferencia de 9 (IC95% 5- 25), p &lt;0,0001. El parto pretérmino fue más frecuente en las pacientes que tenían indicación clínica de uso de antimicrobianos (RR 1,58 IC95% 0,96- 2,61), tras de ajustar el análisis por tiempo de latencia entre la sospecha de infección y el parto se observó que el uso de antimicrobianos reduce en un 46% el riesgo de parto pretérmino, RR 0,54 (IC95% 0,35- 0,83). En las pacientes con cultivo positivo de líquido amniótico la mediana de latencia hasta el parto fue de 4 semanas (RIQ 0- 9) y de 11 (RIQ 8- 15) en las que no se obtuvo aislamiento, con una diferencia de medianas de 6 semanas (IC95% 1- 10).  Conclusiones:  en las pacientes con sospecha de infección inflamación intraamniótica la terapia antibiótica se relacionó con un menor riesgo de parto pretérmino, y el cultivo positivo en líquido amniótico con una menor latencia de la gestación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  preterm birth is an important underlying cause of perinatal morbidity and mortality; one of the primary etiologies is intra-amniotic inflammation/infection, which are associated with adverse perinatal outcomes. The purpose of this study was to assess the relationship between antimicrobial treatment and maternal, fetal, and perinatal clinical outcomes in pregnant patients with suspected intra-amniotic inflammation/infection seen at a nationally- and internationally- recognized university hospital for high-risk obstetric cases in Medellín, Colombia.  Methods:  the researchers conducted an ambispective cohort study of singleton pregnancies with gestational ages &gt; 24 weeks seen at the Clínica Universitaria Bolivariana (CUB) with suspected subclinical intra-amniotic inflammation/infection between January 2011 and December 2021 (n=75). The relationship between the use of antimicrobial treatment and maternal and perinatal clinical outcomes.  Results:  after conducting an analysis of clinical, para-clinical and laboratory evidence, the most statistically significant findings included abdominal pain, acute vaginal bleeding, and the presence of amniotic fluid &#8220;sludge&#8221; found during ultrasound cervicometry. The use of antimicrobial therapy was 1.88 times more common among patients with amniotic fluid &#8220;sludge&#8221; when compared to those without the presence of this clinical finding (CI 95% 1.23 to 2.88), p=0.0009; it was 1.43 times more common among patients experiencing uterine dynamics (CI 95% 1.06 to 1.94), p=0.050. The median difference of leukocytes in amniotic fluid showed an excess of leukocytes per field in patients who received antimicrobials, a difference of 9 leukocytes (CI 95% 5 to 25), p &lt;0.0001. Preterm labor was more frequent in patients in whom there was a clinical indication for the use of antimicrobials (RR 1,58 IC95% 0,96- 2,61). After adjusting the analysis by time of latency between the suspicion of infection and labor, it was observed that the use of antimicrobials reduced the rish of preterm labor by 46% RR 0,54 (IC95% 0,35- 0,83). In culture-positive patients, the median latency period until birth was 4 (IQR 0-9 weeks) and 11 (IQR 8-15 weeks) in culture-negative patients, with a median difference of 6 weeks (CI 95% 1 to 10).  Conclusion:  among patients with suspected intra-amniotic inflammation/infection, antimicrobial therapy is associated with a lower risk for preterm birth, and lower latency period among culture-positive patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[infección]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="es"><![CDATA[líquido amniótico]]></kwd>
<kwd lng="es"><![CDATA[antibacterianos]]></kwd>
<kwd lng="en"><![CDATA[infection]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="en"><![CDATA[amniotic fluid]]></kwd>
<kwd lng="en"><![CDATA[antimicrobials]]></kwd>
</kwd-group>
</article-meta>
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