<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482017000200099</article-id>
<article-id pub-id-type="doi">10.22379/24224022140</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hiperintensidad de tracto corticoespinal en resonancia magnética nuclear como signo de lesión de neurona motora superior en esclerosis lateral amiotrófica, reporte de caso y revisión de literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[High-intensity signal in the corticospinal tract in MRI as a sign of upper motor neuron lesion in amyotrophic lateral sclerosis: Case report and literature review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Enriquez-Marulanda]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Uribe-Becerra]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Granados]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Shinchi]]></surname>
<given-names><![CDATA[Masaru]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad ICESI  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad ICESI  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad ICESI  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>99</fpage>
<lpage>103</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482017000200099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482017000200099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482017000200099&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa que compromete principalmente el sistema motor. Puede ser adquirida de manera esporádica o hereditaria y presenta una incidencia que varía entre 1.5 a 2.7 casos por 100.000 personas/año, con una mediana de supervivencia de 2 a 4 años. Esta enfermedad está caracterizada por compromiso de ambas motoneuronas, superior e inferior y sus manifestaciones clínicas pueden variar desde leve debilidad muscular en etapas tempranas, hasta falla respiratoria asociada en etapas tardías. El diagnóstico es esencialmente clínico y se hace de acuerdo a los criterios revisados de El Escorial para el diagnóstico de Esclerosis Lateral Amiotrófica (ELA). A pesar de esto, el diagnóstico de ELA en etapas tempranas sigue siendo un reto, lo que retrasa su identificación. Por esta razón surge el interés por identificar nuevos biomarcadores que ayuden al diagnóstico más temprano de la entidad. A continuación se presentará el caso de una mujer de 53 años, a la cual se le realiza un diagnóstico de ELA y en la que se encuentra como hallazgo de resonancia magnética cerebral (RM) cerebral, hiperintensidad bilateral del tracto corticoespinal. Discutiremos en este caso la importancia de los hallazgos en neuroimagen como biomarcador de daño en la enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that mainly involves the motor system. It may be sporadic or hereditary, and has an incidence ranging from 1.5 to 2.7 cases per 100,000 persons / year, with a median survival of 2 to 4 years. This disease is characterized by damage of both upper and lower motor neurons, and its clinical manifestations can vary from mild muscle weakness in early stages, to respiratory failure associated in later stages. The diagnosis is based on clinical findings and is made according to the revised El Escorial criteria. Although, the diagnosis of ALS remains a challenge in the early stages and delays it's identification. For this reason, interest to identify new biomarkers that help earlier identification and monitoring of the progression of the disease are being studied. Authors present a case of a woman of 53 years old with a clinical diagnosis of ALS and evidence of corticospinal tract high intensity signal on brain MRI. We will discuss the relevance of brain imaging findings as a biomarker of upper motoneuron damage in ALS.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[esclerosis lateral amiotrófica]]></kwd>
<kwd lng="es"><![CDATA[tractos piramidales]]></kwd>
<kwd lng="es"><![CDATA[biomarcador]]></kwd>
<kwd lng="es"><![CDATA[neuroimagen]]></kwd>
<kwd lng="es"><![CDATA[(DeCS)]]></kwd>
<kwd lng="en"><![CDATA[Amyotropic lateral sclerosis]]></kwd>
<kwd lng="en"><![CDATA[pyramidal tracts]]></kwd>
<kwd lng="en"><![CDATA[biomarkers]]></kwd>
<kwd lng="en"><![CDATA[neuroimaging]]></kwd>
<kwd lng="en"><![CDATA[(MeSH)]]></kwd>
</kwd-group>
</article-meta>
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