<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482020000200110</article-id>
<article-id pub-id-type="doi">10.22379/24224022286</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eficacia y seguridad del tenecteplase en el tratamiento del ACV isquémico agudo]]></article-title>
<article-title xml:lang="en"><![CDATA[Safety and efficacy of tenecteplase in acute ischemia stroke a narrative review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Zafra]]></surname>
<given-names><![CDATA[Javier Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérrez Romero]]></surname>
<given-names><![CDATA[Germán Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Clínica Shaio  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>36</volume>
<numero>2</numero>
<fpage>110</fpage>
<lpage>115</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482020000200110&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482020000200110&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482020000200110&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El alteplase es el único fibrinolítico actualmente autorizado en Colombia para el tratamiento del ACV isquémico agudo. El tenecteplase constituye una nueva alternativa de tratamiento en esta enfermedad al ofrecer mejor perfil farmacológico, mayor eficacia con mejores desenlaces mayores, porcentajes de recanalización, y con seguridad similar a la del alteplase. La posibilidad de desabastecimiento temporal de alteplase con disponibilidad de tenecteplase en Colombia abre la posibilidad de su uso en ACV isquémico agudo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Alteplase is the only one fibrinolytic currently authorized in Colombia for the treatment of acute ischemic stroke. Tenecteplase constitutes a new treatment alternative in this disease by offering a better pharmacological profile, greater efficacy with better outcomes: like higher recanalization percentages and with similar safety profile. The possibility of a temporary shortage of alteplase with availability of tenecteplase in Colombia opens the possibility of its use in acute ischemic stroke.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[infarto cerebral]]></kwd>
<kwd lng="es"><![CDATA[trombosis]]></kwd>
<kwd lng="es"><![CDATA[terapia trombolítica]]></kwd>
<kwd lng="es"><![CDATA[trombectomía]]></kwd>
<kwd lng="es"><![CDATA[hemorragia cerebral (DeCS)]]></kwd>
<kwd lng="en"><![CDATA[stroke]]></kwd>
<kwd lng="en"><![CDATA[ischemic stroke]]></kwd>
<kwd lng="en"><![CDATA[thrombolytic therapy]]></kwd>
<kwd lng="en"><![CDATA[intravenous thrombolysis]]></kwd>
<kwd lng="en"><![CDATA[intracranial hemorrhage (MeSH)]]></kwd>
</kwd-group>
</article-meta>
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