<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482021000200072</article-id>
<article-id pub-id-type="doi">10.22379/24224022337</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neurosífilis]]></article-title>
<article-title xml:lang="en"><![CDATA[Neurosyphilis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Rojas]]></surname>
<given-names><![CDATA[Enrique Steff]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ariza Varón]]></surname>
<given-names><![CDATA[Michael Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>05</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>05</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>72</fpage>
<lpage>80</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482021000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482021000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482021000200072&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La neurosífilis, causada por la espiroqueta Treponema pallidum, con una incidencia de 0,47-2,1 casos por 100 000 habitantes, puede generar neuroinvasión desde etapas tempranas de la infección. Se conoce como "la gran simuladora", con manifestaciones que incluyen casos asintomáticos, compromisos parenquimatosos (encefálicos o medulares) o afectación meníngea con daño vascular asociado. El diagnóstico se basa principalmente en pruebas treponémicas y no treponémicas, tanto séricas como en líquido cefalorraquídeo (LCR). Aquí Un VDRL positivo es la prueba más específica para el diagnóstico, sin embargo, debido a su limitada sensibilidad, ciertos cambios citoquímicos en un contexto clínico adecuado permiten sospechar la enfermedad. Los pacientes con VIH suponen un reto especial. El tratamiento con penicilina cristalina sigue siendo la primera opción terapéutica a dosis de 3-4 millones de unidades IV cada 4 horas o 24 millones de unidades en infusión continua por 10-14 días. En algunos casos se requiere desensibilización o esquemas alternativos. La reacción de Jarisch-Herxheimer secundaria al tratamiento antibiótico es imprevisible y puede generar graves complicaciones, por lo que se recomienda prednisolona 40-60 mg al día por 3 días, iniciando 24 horas antes de la primera dosis de antibioticoterapia. El seguimiento del LCR suele ser útil y necesario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Neurosyphilis is caused by the spirochete Treponema pallidum, with an incidence of 0.47-2.1 cases per 100,000 inhabitants, can generate neuroinvasion from early stages of the infection. It is known as "the great simulator", with manifestations that include cases asymptomatic, parenchymal compromises (encephalic and / or spinal cord) or meningeal involvement with associated vascular damage. Diagnosis is based primarily on treponemal tests and not treponemal, both serum and cerebrospinal fluid (CSF). Here a positive VDRL is the most specific test for diagnosis, however, having limited sensitivity, certain cytochemical changes in an appropriate clinical context allow suspicion of the disease. HIV patients pose a special challenge. Treatment with Crystalline Penicillin continues being the first therapeutic option at doses of 3-4 million units IV every 4 hours or 24 million units in continuous infusion for 10 to 14 days. In some cases it is required desensitization or alternative regimens. The Jarisch-Herxheimer reaction secondary to Antibiotic treatment is unpredictable and can lead to serious complications. recommends Prednisolone 40-60 mg a day for 3 days, starting 24 hours before the first dose of antibiotic therapy. CSF monitoring is often useful and necessary.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[neurosífilis]]></kwd>
<kwd lng="es"><![CDATA[treponema pallidum]]></kwd>
<kwd lng="es"><![CDATA[líquido cefalorraquídeo (DeCS)]]></kwd>
<kwd lng="en"><![CDATA[neurosyphilis]]></kwd>
<kwd lng="en"><![CDATA[treponema pallidum]]></kwd>
<kwd lng="en"><![CDATA[cerebrospinal fluid (MeSH)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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