<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482021000200081</article-id>
<article-id pub-id-type="doi">10.22379/24224022338</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tuberculosis del sistema nervioso central]]></article-title>
<article-title xml:lang="en"><![CDATA[Tuberculosis of the central nervous system]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González S.]]></surname>
<given-names><![CDATA[Edna]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García A.]]></surname>
<given-names><![CDATA[Camila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz P.]]></surname>
<given-names><![CDATA[María Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Pérez]]></surname>
<given-names><![CDATA[Erick]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Sabana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de La Sabana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de La Sabana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de La Sabana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>05</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>05</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>81</fpage>
<lpage>89</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482021000200081&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482021000200081&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482021000200081&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La meningitis por Mycobacterium tuberculosis es la forma extrapulmonar más letal de la tuberculosis activa, con alta prevalencia en los países en desarrollo, lo que constituye un problema de salud pública. Las formas de presentación extrapulmonar que comprometen el sistema nervioso incluyen la tuberculosis meníngea, el granuloma tuberculoso, el absceso tuberculoso y la radiculomielitis, con una presentación clínica inespecífica que dificulta su oportuno diagnóstico, sumado a la falta de pruebas rápidas con alta sensibilidad y especificidad, el alto costo y la pobre asequibilidad a las pruebas en muchos países. El diagnóstico se basa en pruebas microbiológicas, moleculares y en aquellas basadas en la respuesta del huésped. El diagnóstico microbiológico se basa en la tinción de Ziehl-Neelsen y en el cultivo, este último considerado durante mucho tiempo la prueba diagnóstica de oro. El diagnóstico molecular es más preciso utilizando las pruebas de amplificación de ácidos nucleicos, la reacción en cadena de la polimerasa, la prueba de GeneXpert MTB/RIF y la prueba Xpert MTB/ RIF Ultra. Debido a la ausencia de una prueba rápida, existen escalas que ayudan a orientar el diagnóstico del paciente, dentro de las cuales merecen citarse la de Thwaites y la de Marais. El tratamiento de la tuberculosis de cepas sensibles incluye un esquema estructurado con isoniazida, rifampicina, pirazinamida y etambutol, sin embargo, en la actualidad la resistencia a los antimicrobianos constituye un problema, por lo cual el tratamiento en la tuberculosis multirresistente debe ser individualizado, con un régimen de tratamiento prolongado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Mycobacterium tuberculosis meningitis is the most lethal extrapulmonary form of active tuberculosis with high prevalence in developing countries, which constitutes a public health problem. The extrapulmonary presentation that compromise the nervous system include meningeal tuberculosis, tuberculous granuloma, tuberculosis abscess and radiculomyelitis. A nonspecific clinical presentation, the lack of rapid tests with high sensitivity and specificity, the high cost and poor affordability of testing in many countries make the diagnosis more complicated. The diagnosis is based on microbiological, molecular, and host response based testing. Microbiological diagnosis is based on Ziehl - Neelsen staining and culture, the latter long considered the gold standard diagnostic test. Molecular diagnosis is more accurate using nucleic acid amplification tests, the chain reaction of polymerase, the GeneXpert MTB / RIF test, and the Xpert MTB / RIF Ultra test. Given the absence of a rapid test, there are scales that help guide the patient's diagnosis, within which the Thwaites Scale and the Marais Scale deserve to be mentioned. The treatment of tuberculosis of susceptible strains includes a structured regimen with isoniazid, rifampicin, pyrazinamide and ethambutol, however, antimicrobial resistance is currently a problem for which the treatment of multidrug-resistant tuberculosis must be individualized, with a long-term treatment regimen.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[abscesogranuloma]]></kwd>
<kwd lng="es"><![CDATA[Mycobacteriu, tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[tratamiento (DeCS)]]></kwd>
<kwd lng="en"><![CDATA[abscess]]></kwd>
<kwd lng="en"><![CDATA[granuloma]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[treatment (MeSH)]]></kwd>
</kwd-group>
</article-meta>
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</back>
</article>
