<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482025000300007</article-id>
<article-id pub-id-type="doi">10.22379/anc.v41i3.1940</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La vía Sonic Hedgehog en el sistema nervioso: del embrión al tumor]]></article-title>
<article-title xml:lang="en"><![CDATA[The Sonic Hedgehog pathway in the nervous system: From embryo to tumor]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yory Montalvo]]></surname>
<given-names><![CDATA[Nicolás]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velasquez García]]></surname>
<given-names><![CDATA[Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Becerra-Hernández]]></surname>
<given-names><![CDATA[Lina V.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Militar Nueva Granada  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>41</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482025000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482025000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482025000300007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La vía Sonic Hedgehog regula procesos clave en el desarrollo del sistema nervioso central, como la especificación neuronal, la migración celular y la proliferación de células precursoras en el cerebelo. Su disfunción está asociada a diversas patologías cerebrales, incluidos tumores como el meduloblastoma.  Materiales y métodos: Este artículo revisa el papel de la vía Sonic Hedgehog en el desarrollo del sistema nervioso central y su implicación en la tumorogénesis cerebral, destacando los paralelismos moleculares entre ambos procesos. Se incluyen estudios que analizan sus funciones en la comunicación celular, su impacto en el neurodesarrollo y su relación específica con el meduloblastoma.  Resultados: La vía Sonic Hedgehog facilita la diferenciación y migración celular en el desarrollo normal, a través de vías canónicas y no canónicas. En tumores como el meduloblastoma, su activación descontrolada favorece la proliferación, invasividad y resistencia a terapias, lo que afecta negativamente el pronóstico de los pacientes.  Discusión: La similitud de los mecanismos de señalización entre el desarrollo normal y la tumorogénesis sugiere que las alteraciones en la vía Sonic Hedgehog pueden reactivar programas celulares propios del desarrollo embrionario en células tumorales. La identificación de factores moduladores de esta vía es crucial para desarrollar estrategias terapéuticas más efectivas.  Conclusiones: A pesar de las diferencias en su regulación, los paralelismos moleculares entre el desarrollo embrionario y la tumorogénesis resaltan la relevancia de estudiar la vía Sonic Hedgehog. Comprender su rol en ambos contextos abre nuevas perspectivas terapéuticas para superar la resistencia en tumores cerebrales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The Sonic Hedgehog pathway regulates key processes in central nervous system development, including neuronal specification, cell migration, and precursor cell proliferation in the cerebellum. Its dysfunction is associated with various brain pathologies, including tumors such as medulloblastoma.  Materials and Methods: This article reviews the role of the Sonic Hedgehog pathway in central nervous system development and its implications in brain tumorigenesis, highlighting the molecular parallels between both processes. The review includes studies analyzing its functions in cell communication, its impact on neurodevelopment, and its specific relationship with medulloblastoma.  Results: The Sonic Hedgehog pathway facilitates cell differentiation and migration during normal development through both canonical and non-canonical signaling. In tumors such as medulloblastoma, its uncontrolled activation promotes proliferation, invasiveness, and therapy resistance, negatively affecting patient prognosis.  Discussion: The similarity in signaling mechanisms between normal development and tumorigenesis suggests that alterations in the Sonic Hedgehog pathway may reactivate embryonic developmental programs in tumor cells. Identifying modulatory factors of this pathway is crucial for developing more effective therapeutic strategies.  Conclusion: Despite differences in its regulation, the molecular parallels between embryonic development and tumorigenesis highlight the importance of studying the Sonic Hedgehog pathway. Understanding its role in both contexts opens new therapeutic perspectives for overcoming resistance in brain tumors.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sonic Hedgehog]]></kwd>
<kwd lng="es"><![CDATA[sistema nervioso]]></kwd>
<kwd lng="es"><![CDATA[embriogénesis]]></kwd>
<kwd lng="es"><![CDATA[neurodesarrollo]]></kwd>
<kwd lng="es"><![CDATA[tumorogénesis]]></kwd>
<kwd lng="es"><![CDATA[meduloblastoma]]></kwd>
<kwd lng="es"><![CDATA[mecanismos moleculares]]></kwd>
<kwd lng="en"><![CDATA[Sonic Hedgehog]]></kwd>
<kwd lng="en"><![CDATA[Nervous system]]></kwd>
<kwd lng="en"><![CDATA[Embryogenesis]]></kwd>
<kwd lng="en"><![CDATA[Neurodevelopment]]></kwd>
<kwd lng="en"><![CDATA[Tumorigenesis]]></kwd>
<kwd lng="en"><![CDATA[Me-dulloblastoma]]></kwd>
<kwd lng="en"><![CDATA[Molecular mechanisms]]></kwd>
</kwd-group>
</article-meta>
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