<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-9957</journal-id>
<journal-title><![CDATA[Revista colombiana de Gastroenterología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Col Gastroenterol]]></abbrev-journal-title>
<issn>0120-9957</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Gastroenterología  ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-99572017000400337</article-id>
<article-id pub-id-type="doi">10.22516/25007440.177</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Toxicidad hepática causada por medicamentos: revisión estructurada]]></article-title>
<article-title xml:lang="en"><![CDATA[Structured Literature Review of Hepatic Toxicity Caused by Medicines]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cano P]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cifuentes P]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amariles]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia Grupo de promoción y prevención farmacéutica ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Antioquia Grupo de promoción y prevención farmacéutica ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>32</volume>
<numero>4</numero>
<fpage>337</fpage>
<lpage>348</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-99572017000400337&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-99572017000400337&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-99572017000400337&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos:  elaborar un listado actualizado de medicamentos causantes de hepatotoxicidad e identificar, de acuerdo con la evidencia científica, los medicamentos con mayor probabilidad de causar hepatotoxicidad.  Método:  se realizó una búsqueda en PubMed/Medline utilizando términos Mesh: &#8220;liver disease&#8221; y &#8220;drug-induced liver injury&#8221;. La búsqueda se filtró por: reportes de casos, revisiones, ensayos clínicos, metaanálisis y cartas, hasta diciembre de 2015, en inglés, español y francés. Se incluyeron artículos con evidencia de hepatotoxicidad causada por medicamentos y referencias relevantes; fueron excluidos artículos sin relación con los objetivos de la búsqueda, relacionados con hepatotoxicidad por agentes diferentes, concernientes a otras causas de enfermedad hepática o relacionados con ensayos predictivos o células madre. Algunos aspectos de los medicamentos hepatotóxicos fueron: aparición de hepatotoxicidad, tipo de lesión, mecanismos de hepatotoxicidad, factores de riesgo y manifestaciones clínicas. Para valorar la probabilidad de aparición de hepatotoxicidad y del tipo de lesión se establecieron 3 categorías: de&#64257;nida, probable y posible.  Resultados:  se identificaron 610 artículos de los cuales se eligieron 402, se excluyeron 208 artículos. Se elaboró un listado con 181 medicamentos y 17 formas farmacéuticas combinadas o regímenes terapéuticos con probabilidad de causar hepatotoxicidad; de estos, 6 medicamentos tuvieron probabilidad definida (metotrexato, minociclina, vancomicina, everolimus, isoniazida y tamoxifeno).  Conclusiones:  se identificaron más de 180 medicamentos hepatotóxicos, 6 tienen una probabilidad definida, mientras que para la mayoría es posible. La consolidación de la información demostró que diversas categorías de medicamentos tienen mayor probabilidad de ser causantes de hepatotoxicidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objectives:  The aim of this study was to prepare an updated list of drugs that cause hepatotoxicity and identify drugs most likely to cause hepatotoxicity according to scientific evidence.  Method: A search of PubMed/Medline was conducted using the MeSH terms: &#8220;Liver disease&#8221; and &#8220;Drug-induced Liver Injury&#8221;. The search was filtered by case reports, reviews, clinical trials, metaanalyses and letters until December 2015. The search was limited to articles in English, Spanish and French. Articles with evidence of hepatotoxicity caused by medications and relevant references were included. Articles not related to the objectives of the search were excluded. These include articles related to hepatotoxicity due to other agents, articles about other causes of liver disease and/or articles related to predictive tests or stem cells. Some aspects of hepatotoxic drugs were appearance of hepatotoxicity, type of injury, mechanisms of hepatotoxicity, risk factors and clinical manifestations. Three categories, definite, probable and possible, were established to assess probability of hepatotoxicity and type of lesion.  Results:  Six hundred ten articles were identified, 402 articles were chosen, and 208 articles were excluded. A list was prepared with 181 drugs and 17 combined pharmaceutical forms or therapeutic regimens likely to cause hepatotoxicity. Of these, methotrexate, minocycline, vancomycin, everolimus, isoniazid, and tamoxifen were categorized as definite probabilities.  Conclusions:  More than 180 hepatotoxic drugs were identified, six were categorized as definite probabilities, and most were categorized as possibilities. The consolidation of information shows that diverse categories of drugs are likely to cause liver toxicity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad hepática]]></kwd>
<kwd lng="es"><![CDATA[daño hepático inducido por medicamentos]]></kwd>
<kwd lng="en"><![CDATA[Liver disease]]></kwd>
<kwd lng="en"><![CDATA[drug-induced liver damage]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ibáñez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases: epidemiological and clinical features, and exposure to drugs]]></article-title>
<source><![CDATA[J Hepatol]]></source>
<year>2002</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>592-600</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Castañer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[García-Cortés]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An analysis of the causes, characteristics, and consequences of reexposure to a drug or compound responsible for a hepatotoxicity event]]></article-title>
<source><![CDATA[Rev Esp Enferm Dig]]></source>
<year>2008</year>
<volume>100</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>278-84</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-Induced Hepatotoxicity]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2003</year>
<volume>349</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>474-85</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Borlak]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tong]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2013</year>
<volume>58</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>388-96</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tejada]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicidad por fármacos]]></article-title>
<source><![CDATA[Rev clínica Med Fam]]></source>
<year>2010</year>
<volume>3</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>177-91</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sgro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Clinard]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Ouazir]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence of drug-induced hepatic injuries: A French population-based study]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2002</year>
<volume>36</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>451-5</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martí]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Olmo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tosca]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical evaluation of drug-induced hepatitis]]></article-title>
<source><![CDATA[Rev Esp Enfermedades Dig.]]></source>
<year>2005</year>
<volume>97</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>258-65</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bessone]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports]]></article-title>
<source><![CDATA[Ann Hepatol]]></source>
<year>2014</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>231-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liss]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury: what was new in 2008?]]></article-title>
<source><![CDATA[Expert Opin Drug Metab Toxicol]]></source>
<year>2009</year>
<volume>5</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>843-60</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ghabril]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fontana]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rockey]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug induced liver injury caused by intramuscular administered medications: the drug induced liver injury network (DILIN) experience]]></article-title>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>2013</year>
<volume>47</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>553-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Larrey]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology and individual susceptibility to adverse drug reactions affecting the liver]]></article-title>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2002</year>
<volume>22</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>145-55</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramachandran]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kakar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histological patterns in drug-induced liver disease]]></article-title>
<source><![CDATA[J Clin Pathol]]></source>
<year>2009</year>
<volume>62</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>481-92</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fisher]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Vuppalanchi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Saxena]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury]]></article-title>
<source><![CDATA[Arch Pathol Lab Med]]></source>
<year>2015</year>
<volume>139</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>876-87</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castell]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Miñana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis inducida por tóxicos. Mecanismos de toxicidad y patrones de lesión]]></article-title>
<source><![CDATA[GH Contin]]></source>
<year>2003</year>
<volume>2</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>190-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[WM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug induced hepatotoxicity]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>1995</year>
<volume>333</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>1118-27</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaplowitz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury]]></article-title>
<source><![CDATA[Clin Infect Dis]]></source>
<year>2004</year>
<volume>38</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>44-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adams]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ju]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ramaiah]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms of immune-mediated liver injury]]></article-title>
<source><![CDATA[Toxicol Sci]]></source>
<year>2010</year>
<volume>115</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>307-21</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grattagliano]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Bonfrate]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Diogo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biochemical mechanisms in drug-induced liver injury: Certainties and doubts]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2009</year>
<volume>15</volume>
<numero>39</numero>
<issue>39</issue>
<page-range>4865-76</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Cortés]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicidad secundaria a fármacos de uso común]]></article-title>
<source><![CDATA[Gastroenterol Hepatol]]></source>
<year>2005</year>
<volume>28</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>461-72</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tarantino]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Di Minno]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Capone]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury: Is it somehow foreseeable?]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2009</year>
<volume>15</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>2817-33</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bakke]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Manochia]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[De Abajo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective]]></article-title>
<source><![CDATA[Clin Pharmacol Ther]]></source>
<year>1995</year>
<volume>58</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>108-17</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bénichou]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Criteria of drug-induced liver disorders. Report of an international consensus meeting]]></article-title>
<source><![CDATA[J Hepatol]]></source>
<year>1990</year>
<volume>11</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>272-6</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaplowitz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug Induced - Hepatotoxicity]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1986</year>
<volume>104</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>826-39</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reuben]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hy&#8217;s Law]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2004</year>
<volume>39</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>574-8</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Björnsson]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury: Hy&#8217;s rule revisited]]></article-title>
<source><![CDATA[Clin Pharmacol Ther]]></source>
<year>2006</year>
<volume>79</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>521-8</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pessayre]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fromenty]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Berson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Central role of mitochondria in drug-induced liver injury]]></article-title>
<source><![CDATA[Drug Metab Rev]]></source>
<year>2012</year>
<volume>44</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>34-87</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pessayre]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Mansouri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Berson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mitochondrial involvement in drug-induced liver injury]]></article-title>
<source><![CDATA[Handb Exp Pharmacol]]></source>
<year>2010</year>
<volume>196</volume>
<page-range>311-65</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kass]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Price]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of mitochondria in drug-induced cholestatic injury]]></article-title>
<source><![CDATA[Clin Liver Dis]]></source>
<year>2008</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-51</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Labbe]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Pessayre]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fromenty]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies]]></article-title>
<source><![CDATA[Fundam Clin Pharmacol]]></source>
<year>2008</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>335-53</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amacher]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A toxicologist&#8217;s guide to biomarkers of hepatic response]]></article-title>
<source><![CDATA[Hum Exp Toxicol]]></source>
<year>2002</year>
<volume>21</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>253-62</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brunt]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nonalcoholic steatohepatiiis (NASH): further expansion of this clinical entity?]]></article-title>
<source><![CDATA[Liver]]></source>
<year>1999</year>
<volume>19</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>263-4</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunawan]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kaplowitz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical perspectives on xenobiotic-induced hepatotoxicity]]></article-title>
<source><![CDATA[Drug Metab Rev]]></source>
<year>2004</year>
<volume>36</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>301-12</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hayashi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Fontana]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical features, diagnosis, and natural history of drug-induced liver injury]]></article-title>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2014</year>
<volume>34</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>134-44</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hewitt]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Enoch]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Madden]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action]]></article-title>
<source><![CDATA[Crit Rev Toxicol]]></source>
<year>2013</year>
<volume>43</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>537-58</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kleiner]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The pathology of drug-induced liver injury]]></article-title>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2009</year>
<volume>29</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>364-72</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Regev]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Seeff]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Merz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Causality assessment for suspected DILI during clinical phases of drug development]]></article-title>
<source><![CDATA[Drug Saf]]></source>
<year>2014</year>
<volume>37</volume>
<numero>^sS1</numero>
<issue>^sS1</issue>
<supplement>S1</supplement>
<page-range>S47-56</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Camargo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of two clinical scales for causality assessment in hepatotoxicity]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2001</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>123-30</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Trovafloxacin-Induced Acute Hepatitis]]></article-title>
<source><![CDATA[Clin Infect Dis]]></source>
<year>2000</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>400-1</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[López-Ortega]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis tóxicas]]></article-title>
<source><![CDATA[Rev Española Enfermedades Dig]]></source>
<year>2006</year>
<volume>98</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>701</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Björnsson]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicity associated with antiepileptic drugs]]></article-title>
<source><![CDATA[Acta Neurol Scand]]></source>
<year>2008</year>
<volume>118</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>281-90</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amariles]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Giraldo]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Faus]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interacciones medicamentosas: Aproximación para establecer y evaluar su relevancia clínica]]></article-title>
<source><![CDATA[Med Clin (Barc)]]></source>
<year>2007</year>
<volume>129</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-35</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fujimoto]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ohhira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Miyokawa]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acarbose-induced hepatic injury]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>1998</year>
<volume>351</volume>
<numero>9099</numero>
<issue>9099</issue>
<page-range>340</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schiano]]></surname>
<given-names><![CDATA[TD]]></given-names>
</name>
<name>
<surname><![CDATA[Bellary S]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Cassidy]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Subfulminant liver failure and severe hepatotoxicity caused by loratadine use]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1996</year>
<volume>125</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>738-40</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Heller]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Leevy]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Troglitazone-induced fulminant hepatitis. Report of a case withautopsy findings]]></article-title>
<source><![CDATA[J Diabetes Complications]]></source>
<year>2000</year>
<volume>14</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>175-7</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cocozzella]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Curciarello]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Corallini]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propafenone hepatotoxicity: report of two new cases]]></article-title>
<source><![CDATA[Dig Liver Dis]]></source>
<year>2003</year>
<volume>48</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>354-7</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Flaharty]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Chase]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Yaghsezian]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicity associated with amiodarone therapy]]></article-title>
<source><![CDATA[Pharmacotherapy]]></source>
<year>1989</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39-44</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shepherd]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Dawson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Crocker]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Granular cells as a marker of early amiodarone hepatotoxicity: a pathological and analytical study]]></article-title>
<source><![CDATA[J Clin Pathol]]></source>
<year>1987</year>
<volume>40</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>418-23</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jeserich]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ihling]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Allgaier]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute liver failure due to enalapril]]></article-title>
<source><![CDATA[Herz]]></source>
<year>2000</year>
<volume>25</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>689-93</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rosenthal]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Zapiach]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spectrum of methyldopa liver injury]]></article-title>
<source><![CDATA[Am J Gastroenterol]]></source>
<year>1977</year>
<volume>68</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>125-33</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puppala]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Steinheber]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fulminant hepatic failure associated with methyldopa]]></article-title>
<source><![CDATA[Am J Gastroenterol]]></source>
<year>1977</year>
<volume>68</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>578-81</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pelli]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Setti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ceppa]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune hepatitis revealed by atorvastatin]]></article-title>
<source><![CDATA[Eur JGastroenterol Hepatol]]></source>
<year>2003</year>
<volume>15</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>921-4</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stolk]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Becx]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kuypers]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Severe hepatic side effects of ezetimibe]]></article-title>
<source><![CDATA[Clin Gastroenterol Hepatol]]></source>
<year>2006</year>
<volume>4</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>908-11</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jonas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eidson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propylthiouracil hepatotoxicity: two pediatric cases and review of literature]]></article-title>
<source><![CDATA[J Pediatr Gastroenterol Nutr]]></source>
<year>1988</year>
<volume>7</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>776-8</page-range></nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Melamud]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Lurie]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Goldin]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Methylprednisolone-induced liver injury: a diagnostic challenge]]></article-title>
<source><![CDATA[IMAJ]]></source>
<year>2014</year>
<volume>16</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>180-1</page-range></nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zeckel]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk of hepatic events in patients treated with vancomycin in clinical studies: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Drug saf]]></source>
<year>2011</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>73-82</page-range></nlm-citation>
</ref>
<ref id="B56">
<label>56</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lawrenson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Seaman]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Sundström]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data]]></article-title>
<source><![CDATA[Drug Saf]]></source>
<year>2000</year>
<volume>23</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>333-49</page-range></nlm-citation>
</ref>
<ref id="B57">
<label>57</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Senior]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-related hepatotoxicity]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2006</year>
<volume>354</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>731-9</page-range></nlm-citation>
</ref>
<ref id="B58">
<label>58</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prince]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Burt]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis]]></article-title>
<source><![CDATA[Gut]]></source>
<year>2002</year>
<volume>50</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>436-9</page-range></nlm-citation>
</ref>
<ref id="B59">
<label>59</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hydes]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jaynes]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication]]></article-title>
<source><![CDATA[BMJ Case Rep]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B60">
<label>60</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Edoute]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Karmon]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Roguin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fatal liver necrosis associated with the use of nitrofurantoin]]></article-title>
<source><![CDATA[Isr Med Assoc J]]></source>
<year>2001</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>382-3</page-range></nlm-citation>
</ref>
<ref id="B61">
<label>61</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koek]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Striker]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Blok]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flucloxacillin-associated hepatic iniurv]]></article-title>
<source><![CDATA[Liver]]></source>
<year>1994</year>
<volume>14</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>225-9</page-range></nlm-citation>
</ref>
<ref id="B62">
<label>62</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clay]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hanson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pope]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Telithromycin: a possible cause of severe liver damage?]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2006</year>
<volume>144</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>I42</page-range></nlm-citation>
</ref>
<ref id="B63">
<label>63</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adriaenssens]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Roskams]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Steger]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicity related to itraconazole: report of three cases]]></article-title>
<source><![CDATA[Acta Clin Belg]]></source>
<year>2001</year>
<volume>56</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>364-9</page-range></nlm-citation>
</ref>
<ref id="B64">
<label>64</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jacobson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hanks]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrell]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fatal acute hepatic necrosis due to fluconazole]]></article-title>
<source><![CDATA[Am J Med]]></source>
<year>1994</year>
<volume>96</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>188-90</page-range></nlm-citation>
</ref>
<ref id="B65">
<label>65</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chien]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>1997</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>103-7</page-range></nlm-citation>
</ref>
<ref id="B66">
<label>66</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Parys]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Evenepoel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Van Damme]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ketoconazole-induced hepatitis: a case with a definite cause-effect relationship]]></article-title>
<source><![CDATA[Liver]]></source>
<year>1987</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-30</page-range></nlm-citation>
</ref>
<ref id="B67">
<label>67</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akhtar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mathieson]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Arey]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatic histopathology and clinical characteristics associated with antiretroviral therapy in HIV patients without viral hepatitis]]></article-title>
<source><![CDATA[Eur JGastroenterol Hepatol]]></source>
<year>2008</year>
<volume>20</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1194-204</page-range></nlm-citation>
</ref>
<ref id="B68">
<label>68</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macías]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Neukam]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Mallolas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver toxicity of initial antiretroviral drug regimens including two nucleoside analogs plus one non-nucleoside analog or one ritonavir-boosted protease inhibitor in HIV/HCV-coinfected patients]]></article-title>
<source><![CDATA[HIV Clin Trials]]></source>
<year>2012</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>61-9</page-range></nlm-citation>
</ref>
<ref id="B69">
<label>69</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clarke]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Harrington]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Condon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Late onset hepatitis and prolonged deterioration in hepatic function assciated with nevirapine therapy]]></article-title>
<source><![CDATA[Int J STD AIDS]]></source>
<year>2000</year>
<volume>11</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>336-7</page-range></nlm-citation>
</ref>
<ref id="B70">
<label>70</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McWhirter]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kitteringham]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: a review of mechanisms and outcomes]]></article-title>
<source><![CDATA[Crit Rev Oncol Hematol]]></source>
<year>2013</year>
<volume>88</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>404-15</page-range></nlm-citation>
</ref>
<ref id="B71">
<label>71</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemotherapy-associated hepatotoxicity: do we need to be concerned?]]></article-title>
<source><![CDATA[Ann Surg Oncol]]></source>
<year>2009</year>
<volume>16</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2391-4</page-range></nlm-citation>
</ref>
<ref id="B72">
<label>72</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Agúndez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of nonsteroidal anti-inflammatory drug-induced hepatotoxicity]]></article-title>
<source><![CDATA[Expert Opin Drug Metab Toxicol]]></source>
<year>2011</year>
<volume>7</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>817-28</page-range></nlm-citation>
</ref>
<ref id="B73">
<label>73</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boelsterli]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Zimmerman]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kretz-Rommel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology]]></article-title>
<source><![CDATA[Crit Rev Toxicol]]></source>
<year>1995</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>207-35</page-range></nlm-citation>
</ref>
<ref id="B74">
<label>74</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prescott]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxicity of mild analgesics]]></article-title>
<source><![CDATA[Br J Clin Pharmacol]]></source>
<year>1980</year>
<volume>10</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>373S-9S</page-range></nlm-citation>
</ref>
<ref id="B75">
<label>75</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Black]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acetaminophen hepatotoxicity]]></article-title>
<source><![CDATA[Ann Rev Med]]></source>
<year>1984</year>
<volume>35</volume>
<page-range>577-93</page-range></nlm-citation>
</ref>
<ref id="B76">
<label>76</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quartuccio]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Maset]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Soardo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus]]></article-title>
<source><![CDATA[J Clin Rheumatol]]></source>
<year>2014</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>349-51</page-range></nlm-citation>
</ref>
<ref id="B77">
<label>77</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dwyer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Klatskin]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Halothane hepatitis: benign resolution of a severe lesion]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1978</year>
<volume>89</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>212-5</page-range></nlm-citation>
</ref>
<ref id="B78">
<label>78</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Munro]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Snider]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Magee]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Halothane-associated hepatitis in a 6-year-old boy: evidence for native liver regeneration following failed treatment with auxiliary liver transplantion]]></article-title>
<source><![CDATA[Anesthesiology]]></source>
<year>1998</year>
<volume>89</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>524-7</page-range></nlm-citation>
</ref>
<ref id="B79">
<label>79</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Camilleri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Victorino]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hodgson]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Halothane aggravation of chronic liver disease]]></article-title>
<source><![CDATA[Acta Med Port]]></source>
<year>1984</year>
<volume>5</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>194-6</page-range></nlm-citation>
</ref>
<ref id="B80">
<label>80</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Colleti]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Trainer]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Krawisz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reversible valproate fulminant hepatic failure]]></article-title>
<source><![CDATA[J Pediatr Gastroenterol Nutr]]></source>
<year>1986</year>
<volume>5</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>990-4</page-range></nlm-citation>
</ref>
<ref id="B81">
<label>81</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bicknese]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[May]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Hickey]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early childhood hepatocerebral degeneration misdiagnosed as valproate hepatotoxicity]]></article-title>
<source><![CDATA[Ann Neurol]]></source>
<year>1992</year>
<volume>32</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>767-75</page-range></nlm-citation>
</ref>
<ref id="B82">
<label>82</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Goodman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Van Dyne]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Granulomatous hepatitis secondary to carbamazepine]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1981</year>
<volume>95</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>64-5</page-range></nlm-citation>
</ref>
<ref id="B83">
<label>83</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Horowitz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Patwardhan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Marcus]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatotoxic reactions associated with carbamazepine therapy]]></article-title>
<source><![CDATA[Epilepsia]]></source>
<year>1988</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>149-54</page-range></nlm-citation>
</ref>
<ref id="B84">
<label>84</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bhayana]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Appasami]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Thapa]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lamotrigine-induced vanishing bile duct syndrome in a child]]></article-title>
<source><![CDATA[J Pediatr Gastroenterol Nutr]]></source>
<year>2012</year>
<volume>55</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>e147-8</page-range></nlm-citation>
</ref>
<ref id="B85">
<label>85</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mecarelli]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Pulitano]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mingoia]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (MARS)]]></article-title>
<source><![CDATA[Epilepsia]]></source>
<year>2005</year>
<volume>46</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1687-9</page-range></nlm-citation>
</ref>
<ref id="B86">
<label>86</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tostmann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Boeree]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Aarnoutse]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antituberculosis drug-induced hepatotoxicity: concise up-to-date review]]></article-title>
<source><![CDATA[J Gastroenterol Hepatol]]></source>
<year>2008</year>
<volume>23</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>192-202</page-range></nlm-citation>
</ref>
<ref id="B87">
<label>87</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cramer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lohse]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Burchard]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation]]></article-title>
<source><![CDATA[Transpl Int]]></source>
<year>2010</year>
<volume>23</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>231-3</page-range></nlm-citation>
</ref>
<ref id="B88">
<label>88</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yew]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Leung]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antituberculosis drugs and hepatotoxicity]]></article-title>
<source><![CDATA[Respirology]]></source>
<year>2006</year>
<volume>11</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>699-707</page-range></nlm-citation>
</ref>
<ref id="B89">
<label>89</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lucena]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determinants of the clinical expression of amoxicillin- clavulanate hepatotoxicity: a prospective series from Spain]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2006</year>
<volume>44</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>850-6</page-range></nlm-citation>
</ref>
<ref id="B90">
<label>90</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ortu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Weimer]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Floridia]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Raltegravir, tenofovir and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity]]></article-title>
<source><![CDATA[Eur J Med Res]]></source>
<year>2010</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>81-3</page-range></nlm-citation>
</ref>
<ref id="B91">
<label>91</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[D&#8217;Cruz]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wimmer]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Harcke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Veno-occlusive disease of the liver in children following chemotherapy for acute myelocytic leukemia]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>1983</year>
<volume>52</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1803-7</page-range></nlm-citation>
</ref>
<ref id="B92">
<label>92</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaplowitz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Idiosyncratic drug hepatotoxicity]]></article-title>
<source><![CDATA[Nat Rev Drug Discov]]></source>
<year>2005</year>
<volume>4</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>489-99</page-range></nlm-citation>
</ref>
<ref id="B93">
<label>93</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schumacher]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanistic review of drug-induced steatohepatitis]]></article-title>
<source><![CDATA[Toxicol Appl Pharmacol]]></source>
<year>2015</year>
<volume>289</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>40-7</page-range></nlm-citation>
</ref>
<ref id="B94">
<label>94</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fathi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Mitros]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hoffman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Longitudinal measurement of methotrexate liver concentrations does not correlate with liver damage, clinical efficacy, or toxicity during a 3.5 year double blind study in rheumatoid arthritis]]></article-title>
<source><![CDATA[J Rheumatol]]></source>
<year>2002</year>
<volume>29</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2092-8</page-range></nlm-citation>
</ref>
<ref id="B95">
<label>95</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hayashi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Fontana]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Chalasani]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Under-reporting and poor adherence to monitoring guidelines for severe cases of isoniazid hepatotoxicity]]></article-title>
<source><![CDATA[Clin Gastroenterol Hepatol]]></source>
<year>2015</year>
<volume>13</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1676-82</page-range></nlm-citation>
</ref>
<ref id="B96">
<label>96</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rigas]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rosenfeld]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Barwick]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Amiodarone hepatotoxicity. A clinicopathologic study of five patients]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1986</year>
<volume>104</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>348-51</page-range></nlm-citation>
</ref>
<ref id="B97">
<label>97</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jain]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bowlus]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[James]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Granular cells as a marker of early amiodarone hepatotoxicity]]></article-title>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>2000</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>241-3</page-range></nlm-citation>
</ref>
<ref id="B98">
<label>98</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lupon-Rosés]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Simó-Canonge]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lu-Cortez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Probable early acute hepatitis with parenteral amiodarone]]></article-title>
<source><![CDATA[Clin Cardiol]]></source>
<year>1986</year>
<volume>9</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>223-5</page-range></nlm-citation>
</ref>
<ref id="B99">
<label>99</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Onakpoya]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Heneghan]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Aronson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature]]></article-title>
<source><![CDATA[BMC Med]]></source>
<year>2016</year>
<volume>14</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1-11</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
