<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-9957</journal-id>
<journal-title><![CDATA[Revista colombiana de Gastroenterología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Col Gastroenterol]]></abbrev-journal-title>
<issn>0120-9957</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Gastroenterología  ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-99572018000400459</article-id>
<article-id pub-id-type="doi">10.22516/25007440.315</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Pancreatitis aguda severa por hipertrigliceridemia en el adulto: presentación de caso clínico, diagnóstico y tratamiento]]></article-title>
<article-title xml:lang="en"><![CDATA[Severe acute pancreatitis due to hypertriglyceridemia in adults: Clinical case presentation, diagnosis and treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marín S]]></surname>
<given-names><![CDATA[Juliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez S]]></surname>
<given-names><![CDATA[Héctor Conrado]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Ch]]></surname>
<given-names><![CDATA[Claudia Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Santa Fe de Bogotá  ]]></institution>
<addr-line><![CDATA[Bogotá D. C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Hernando Moncaleano Perdomo  ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Santa Fe de Bogotá  ]]></institution>
<addr-line><![CDATA[Bogotá D. C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>33</volume>
<numero>4</numero>
<fpage>459</fpage>
<lpage>463</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-99572018000400459&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-99572018000400459&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-99572018000400459&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La pancreatitis es una de las causas más frecuentes de admisión hospitalaria gastrointestinal; en 2009 representó más de 275 000 ingresos a urgencias en Estados Unidos (1). Por su parte, la hipertrigliceridemia es la tercera causa más frecuente, considerándose como de alto riesgo para el desarrollo de pancreatitis los valores superiores a 1000 mg/dL (2); este grupo de pacientes tiene peor pronóstico que quienes cursan con pancreatitis de otra etiología, aunque aún no se logra definir de forma clara y estandarizada un rango de triglicéridos (TAG) que se relacione con la gravedad de la pancreatitis aguda. Existen varios mecanismos fisiopatológicos que explican la aparición de pancreatitis en el contexto de la hipertrigliceridemia, uno de los mejor estudiados es el papel tóxico directo de los ácidos grasos libres sobre el tejido pancreático (3) y otro mecanismo ampliamente acogido es la obstrucción vascular mediada por los quilomicrones, dada la disminución de la expresión genética de la lipoproteína lipasa (LPL) (4). Por su parte, el éxito del tratamiento de esta enfermedad se basa en disminuir los niveles de TAG a menos de 500 mg/dL, teniendo para esto entre otras herramientas la plasmaféresis, tratamiento que ofrece rapidez y efectividad en la reducción de los niveles de TAG.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Pancreatitis is one of the most frequent gastrointestinal causes of hospital admission. In 2009, it accounted for more than 275,000 admissions to emergency departments in the United States. (1) Hypertriglyceridemia is the third most frequent cause of pancreatitis, and triglyceride levels over 1,000 mg/dl are considering to indicate high risk for its development. (2) This group of patients has a worse prognosis than those with pancreatitis of other etiologies, but to date, no clear standard definition of how the range of triglyceride levels is related to the severity of acute pancreatitis has been defined. There are several pathophysiological mechanisms that explain the onset of pancreatitis in the context of hypertriglyceridemia. One of the best studied is the toxic role of free fatty acids on pancreatic tissue. (3) Another widely accepted mechanism is vascular obstruction mediated by chylomicrons given the decrease in the genetic expression of lipoprotein lipase (LPL). (4) Successful treatment of this disease is based on lowering triglyceride levels below 500 mg/dl. One fast and effective tool for achieving this is plasmapheresis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Pancreatitis aguda]]></kwd>
<kwd lng="es"><![CDATA[triglicéridos]]></kwd>
<kwd lng="es"><![CDATA[plasmaféresis]]></kwd>
<kwd lng="en"><![CDATA[Acute pancreatitis]]></kwd>
<kwd lng="en"><![CDATA[triglycerides]]></kwd>
<kwd lng="en"><![CDATA[plasmapheresis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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