<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-9957</journal-id>
<journal-title><![CDATA[Revista colombiana de Gastroenterología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. Gastroenterol.]]></abbrev-journal-title>
<issn>0120-9957</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Gastroenterología  ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-99572022000100003</article-id>
<article-id pub-id-type="doi">10.22516/25007440.538</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Severity Markers of Acute Appendicitis: Diagnostic Test Study]]></article-title>
<article-title xml:lang="es"><![CDATA[Marcadores de severidad de la apendicitis aguda: estudio de prueba diagnóstica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Rodríguez]]></surname>
<given-names><![CDATA[Ledmar Jovanny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrera-Jerez]]></surname>
<given-names><![CDATA[Jonathan Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila-Ávila]]></surname>
<given-names><![CDATA[Kelly Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Monguí]]></surname>
<given-names><![CDATA[David Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz-Espinosa]]></surname>
<given-names><![CDATA[Brayan Rojeiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Boyacá  ]]></institution>
<addr-line><![CDATA[Tunja ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Regional de la Orinoquía  ]]></institution>
<addr-line><![CDATA[Yopal ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Boyacá  ]]></institution>
<addr-line><![CDATA[Tunja ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>3</fpage>
<lpage>9</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-99572022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-99572022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-99572022000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Acute appendicitis (AA) is one of the most frequent abdominal surgical pathologies globally, with appendectomy being the most performed emergency surgery.  Aim: To determine potential markers of AA severity for diagnostic purposes and timely management, thus avoiding possible complications.  Materials and methods: This research relies on a randomized sample of 239 patients diagnosed with AA at the Orinoquía Regional Hospital, Colombia. We analyzed blood count, C-reactive protein (CRP), and neutrophil/lymphocyte ratio (NLR) records and established their relationship with the AA surgical findings described by Guzmán-Valdivia.  Results: In the emergency department, these reactants can provide an approximate diagnosis as markers of the AA severity, with CRP &gt; 15 mg/dL (diagnostic accuracy of 76.15 %) and NLR &gt; 85 % (diagnostic accuracy of 61.09 %) having the best initial operating performance. Regarding complications such as intestinal perforation, we found a statistical relationship; CRP &gt; 15 mg/dL and NLR &gt; 85 % were the markers with the highest predictive performance, with OR 14.46 and OR 2. 17, respectively, regarding Guzmán-Valdivia&#8217;s findings.  Conclusions: CRP and NLR &gt; 85 % are the acute phase reactants with the best diagnostic characteristics to predict potential AA complications.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  la apendicitis aguda (AA) es una de las patologías quirúrgicas abdominales más frecuentes en el mundo, siendo la apendicectomía, la cirugía de emergencia más realizada a nivel mundial.  Objetivo:  determinar los posibles marcadores de severidad en la apendicitis aguda con fines diagnósticos y para el manejo oportuno de la apendicitis y, de esta manera, evitar posibles complicaciones.  Metodología:  esta investigación se basó de una muestra aleatorizada de un total de 239 pacientes con diagnóstico de apendicitis aguda en el Hospital Regional de Orinoquía, Colombia. Se analizaron registros de cuadro hemático, proteína C reactiva (PCR) e índice de neutrófilo/linfocito (INL), y se estableció la relación de los mismos con los hallazgos quirúrgicos de apendicitis aguda descritos por Guzmán-Valdivia.  Resultados:  en el servicio de urgencias, estos reactantes son capaces de realizar una aproximación en el diagnóstico y como marcadores de la severidad de la AA, siendo la PCR &gt; 15 mg/dL (precisión diagnóstica 76,15 %) y el porcentaje de neutrófilos &gt; 85 % (precisión diagnóstica 61,09 %) los de mejor rendimiento operativo inicial. En cuanto a las complicaciones, como la perforación intestinal, se encontró en relación estadística, que la PCR &gt; 15 mg/dL y el porcentaje de neutrófilos &gt; 85 % fueron los marcadores con mayor rendimiento predictivo, con OR 14,46 y OR 2,17, respectivamente. Lo anterior en relación con los hallazgos descritos por Guzmán-Valdivia.  Conclusiones:  la elevación de la PCR y del porcentaje de neutrófilos &gt; 85 % son los reactantes de fase aguda que presentan mejores características diagnósticas y para predecir posibles complicaciones de la apendicitis aguda.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Appendicitis]]></kwd>
<kwd lng="en"><![CDATA[perforation]]></kwd>
<kwd lng="en"><![CDATA[biomarkers]]></kwd>
<kwd lng="en"><![CDATA[severity]]></kwd>
<kwd lng="es"><![CDATA[Apendicitis]]></kwd>
<kwd lng="es"><![CDATA[perforación]]></kwd>
<kwd lng="es"><![CDATA[biomarcadores]]></kwd>
<kwd lng="es"><![CDATA[severidad]]></kwd>
</kwd-group>
</article-meta>
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