<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-9957</journal-id>
<journal-title><![CDATA[Revista colombiana de Gastroenterología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. Gastroenterol.]]></abbrev-journal-title>
<issn>0120-9957</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Gastroenterología  ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-99572023000300383</article-id>
<article-id pub-id-type="doi">10.22516/25007440.980</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Granulomatous hepatitis, deciphering an elusive spectrum: a clinical case-based approach]]></article-title>
<article-title xml:lang="es"><![CDATA[Hepatitis granulomatosa, descifrando un soslayado espectro: enfoque basado en un caso clínico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rondón-Carvajal]]></surname>
<given-names><![CDATA[Julián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Carrasco]]></surname>
<given-names><![CDATA[Óscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lara-Viáfara]]></surname>
<given-names><![CDATA[Melissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Libre  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Libre  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<fpage>383</fpage>
<lpage>391</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-99572023000300383&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-99572023000300383&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-99572023000300383&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Granulomatous hepatitis is a well-defined histopathologic entity characterized by aggregates of modified macrophages (epithelioid in appearance) and other inflammatory cells that accumulate after persistent exposure to antigens. It induces a cellular immune response mediated by the release of various cytokines (including interferon-gamma [INF-&#947;], tumor necrosis factor-alpha [TNF-&#945;], and interleukin 12 [IL-12]) that stimulate mononuclear cell fusion, culminating in the formation of multinucleated giant cells with a surrounding border of lymphocytes and fibroblasts. It represents between 2% and 15% of all pathological liver studies, usually during an infiltrative or cholestatic biochemical pattern. A practical approach is proposed based on a challenging clinical case of a patient with a fever of unknown origin in an intermediate incidence area for tuberculosis, such as Colombia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La hepatitis granulomatosa es una entidad histopatológica bien definida que se caracteriza por la presencia de agregados de macrófagos modificados (de aspecto epitelioide) y otras células inflamatorias que se acumulan luego de la exposición persistente a antígenos, lo que induce una respuesta inmunitaria celular mediada por la liberación de varias citocinas (entre las que se destacan el interferón gamma [INF-&#947;], el factor de necrosis tumoral alfa [TNF-&#945;] y la interleucina 12 [IL-12]) que estimulan la fusión de células mononucleares para culminar en la formación de células gigantes multinucleadas con un borde circundante de linfocitos y fibroblastos. Representa entre el 2 % y el 15 % de todos los estudios anatomopatológicos de hígado, en el curso por lo general de un patrón bioquímico de tipo infiltrativo o colestásico. Se propone un enfoque práctico a partir de un caso clínico retador de un paciente con fiebre de origen desconocido en una zona de incidencia intermedia para tuberculosis, como lo es Colombia.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Granuloma]]></kwd>
<kwd lng="en"><![CDATA[hepatitis]]></kwd>
<kwd lng="en"><![CDATA[sarcoidosis]]></kwd>
<kwd lng="en"><![CDATA[tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[fever of unknown origin]]></kwd>
<kwd lng="es"><![CDATA[Granuloma]]></kwd>
<kwd lng="es"><![CDATA[hepatitis]]></kwd>
<kwd lng="es"><![CDATA[sarcoidosis]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[fiebre de origen desconocido]]></kwd>
</kwd-group>
</article-meta>
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</ref-list>
</back>
</article>
