<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-9957</journal-id>
<journal-title><![CDATA[Revista colombiana de Gastroenterología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. Gastroenterol.]]></abbrev-journal-title>
<issn>0120-9957</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Gastroenterología  ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-99572024000200187</article-id>
<article-id pub-id-type="doi">10.22516/25007440.1132</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Disorders of Gut-Brain Interaction (Functional Gastrointestinal Disorders): Neuromodulators in Clinical Practice (Part I)]]></article-title>
<article-title xml:lang="es"><![CDATA[Trastornos de la interacción cerebro-intestino (trastornos funcionales digestivos): neuromoduladores en la práctica clínica (parte I)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pineda-Ovalle]]></surname>
<given-names><![CDATA[Luis Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Páramo-Hernández]]></surname>
<given-names><![CDATA[David Benigno]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moya-Valenzuela]]></surname>
<given-names><![CDATA[Laura Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Concha-Mejía]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Páramo-Díaz]]></surname>
<given-names><![CDATA[Juan David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Salud Digestiva  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Salud Digestiva  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Salud Digestiva  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Clínica del Country  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Pontificia Universidad Javeriana  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>39</volume>
<numero>2</numero>
<fpage>187</fpage>
<lpage>193</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-99572024000200187&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-99572024000200187&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-99572024000200187&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  This review article develops the basic principles for the use and action mechanisms of neuromodulators applied in clinical practice and their role in treating different disorders of gutbrain interaction (DGBI), particularly, esophageal disorders in part I.  Materials and methods:  The working group reviewed the most frequent pathologies and medications used according to the most recent literature and presented those with the best clinical evidence in each case.  Results:  Due to the diversity of disorders, types of studies, and therapeutic options, we decided to present the evidence with the best results for each case. We determined the doses used, their results, and the side effects of each one.  Conclusions:  The basic principles of the use and mechanisms of action of the main neuromodulators were reviewed, including their use in this section in the main esophageal gastrointestinal functional disorders. Given that the available evidence is not definitive, more controlled clinical trials are needed for each condition to confirm the effectiveness and safety of neuromodulators.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  En este artículo de revisión se desarrollan los principios básicos para el uso y los mecanismos de acción de los neuromoduladores utilizados en la práctica clínica y su papel en el tratamiento de los diferentes trastornos de la interacción cerebro-intestino (TICI), particularmente los esofágicos en la parte I.  Materiales y métodos:  El grupo de trabajo revisó las patologías más frecuentes y los medicamentos utilizados según la bibliografía más reciente, y presenta a los que tienen la mejor evidencia clínica en cada caso.  Resultados:  Debido a la diversidad de trastornos, tipos de estudios y opciones terapéuticas, se decide presentar las evidencias con los mejores resultados para cada caso, y en cada uno se determinan las dosis utilizadas, sus resultados y efectos colaterales.  Conclusiones:  Se revisan los principios básicos del uso y mecanismos de acción de los principales neuromoduladores, así como la utilización de los mismos en esta sección en los principales trastornos funcionales gastrointestinales esofágicos. Dado que la evidencia disponible no resulta definitiva, para cada condición se requieren más experimentos clínicos controlados que puedan confirmar la efectividad y seguridad de los neuromoduladores.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Antidepressants]]></kwd>
<kwd lng="en"><![CDATA[antipsychotics]]></kwd>
<kwd lng="en"><![CDATA[central neuromodulators]]></kwd>
<kwd lng="en"><![CDATA[disorders of gut brain interaction]]></kwd>
<kwd lng="en"><![CDATA[functional gastrointestinal disorder]]></kwd>
<kwd lng="es"><![CDATA[Antidepresivos]]></kwd>
<kwd lng="es"><![CDATA[antipsicóticos]]></kwd>
<kwd lng="es"><![CDATA[neuromoduladores centrales]]></kwd>
<kwd lng="es"><![CDATA[trastornos de la interacción cerebro-intestino]]></kwd>
<kwd lng="es"><![CDATA[trastorno gastrointestinal funcional]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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