<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0319</journal-id>
<journal-title><![CDATA[Medicas UIS]]></journal-title>
<abbrev-journal-title><![CDATA[Medicas UIS]]></abbrev-journal-title>
<issn>0121-0319</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-03192018000200009</article-id>
<article-id pub-id-type="doi">10.18273/revmed.v31n2-2018001</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Perfil microbiológico y resistencia bacteriana en una unidad de cuidados intensivos de Pereira, Colombia, 2015]]></article-title>
<article-title xml:lang="en"><![CDATA[Microbiologic profile and antibiotic resistance at an intensive care unit in Pereira, Colombia, 2015]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-González]]></surname>
<given-names><![CDATA[José F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Duque]]></surname>
<given-names><![CDATA[Jorge A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Tecnológica de Pereira  ]]></institution>
<addr-line><![CDATA[Pereira Risaralda]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Tecnológica de Pereira  ]]></institution>
<addr-line><![CDATA[Pereira Risaralda]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>31</volume>
<numero>2</numero>
<fpage>9</fpage>
<lpage>15</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-03192018000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-03192018000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-03192018000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: la terapia antibiótica es eficaz en muchos tipos de infecciones, pero su uso excesivo promueve la propagación de microorganismos resistentes, la cual se asocia con aumentos en morbilidad, mortalidad, estancia hospitalaria y costos asociados; panorama frecuente en la unidad de cuidados intensivos.  Objetivo: describir perfil microbiológico y de resistencia bacteriana en microorganismos cultivados de pacientes hospitalizados en una unidad de cuidado intensivo en la ciudad de Pereira.  Materiales y método: estudio retrospectivo. Se analizaron perfiles de sensibilidad/resistencia de pacientes atendidos durante el primer semestre de 2015. La información fue extraída de historias clínicas y reportes de laboratorio. Las pruebas de sensibilidad/resistencia antimicrobiana se realizaron con el software WHONET. El análisis de tendencia fue realizado con el software STATA.  Resultados: se incluyeron 62 pacientes con edad media de 57,9 años, 32 eran mujeres. La mayor positividad fue para hemocultivos y urocultivos. Los microorganismos más frecuentemente aislados fueron: E. coli (con resistencias del 95, 75 y 70% para ampicilina, cefazolina y piperazilina/tazobactam respectivamente), K. pneumoniae (resistencias del 46% para ampicilina/sulbactam, piperazilina/tazobactam y cefazolina), S. aureus y P. aeuriginosa.  Conclusiones: El perfil de resistencia encontrado en la población de estudio es alarmante, asociado a una alta prevalencia de p-lactamasas tipo AmpC (n=i6) y Betalactamasas de espectro extendido (n=8). E. Coli, K. pneumoniae y P. aeruginosa presentan valores de resistencia importante para antibióticos de uso común en UCI como penicilinas de amplio espectro y cefalosporinas. MÉD.UIS. 2018;31(2):9-15.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: antibiotic therapy is an effective treatment for many types of infections, but their overuse promotes the spread of resistant microorganisms, which is associated with increases in morbidity, mortality, length of stay, and hospital expenditures; a frequent difficulty in the intensive care unit.  Objective: to evaluate the prevalence of microorganisms and describe the profiles of bacterial resistance in isolated foci of patients in one intensive care unit in Pereira.  Materials and method: a retrospective study was performed. Sensitivity and resistance profiles of hospitalized patients during the first half of 2015 were analyzed. The information was extracted from clinical histories and laboratory reports. Antimicrobial susceptibility testing was performed with WHONET. Trend analyzes were done with STATA.  Results: 62 patients were included with a mean age of 57.9 years, 32 were female. The highest positivity was for blood cultures and urine cultures. The most frequently isolated microorganisms were: E. coli (resistance of 95%, 75% and 70% for ampicillin, cefazoline and piperaziline/tazobactam respectively), K. pneumonia (resistance of 46% to ampicillin/sulbactam, piperaziline/tazobactam and cefazolina), S. aureus and P. aeruginosa.  Conclusion: Resistance profile found is alarming, associated with a high prevalence of Ampc-type p-lactamases (n=i6) and extended-spectrum p-lactamases (n=8). E. coli, K. pneumoniae and P. aeruginosa exhibit important resistance values for antibiotics commonly used in UCI as broad-spectrum penicillins and cephalosporins. MÉD.UIS. 2018;31(2):9-15.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Infección]]></kwd>
<kwd lng="es"><![CDATA[Bacteriemia]]></kwd>
<kwd lng="es"><![CDATA[Unidades de Cuidados Intensivos]]></kwd>
<kwd lng="es"><![CDATA[Antibacterianos]]></kwd>
<kwd lng="es"><![CDATA[Farmacorresistencia Microbiana]]></kwd>
<kwd lng="es"><![CDATA[Control de infecciones]]></kwd>
<kwd lng="en"><![CDATA[Infection]]></kwd>
<kwd lng="en"><![CDATA[Bacteremia]]></kwd>
<kwd lng="en"><![CDATA[Intensive Care Units]]></kwd>
<kwd lng="en"><![CDATA[Anti-bacterial Agents]]></kwd>
<kwd lng="en"><![CDATA[Drug Resistance]]></kwd>
<kwd lng="en"><![CDATA[Microbial]]></kwd>
<kwd lng="en"><![CDATA[Infection Control]]></kwd>
</kwd-group>
</article-meta>
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