<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0319</journal-id>
<journal-title><![CDATA[Medicas UIS]]></journal-title>
<abbrev-journal-title><![CDATA[Medicas UIS]]></abbrev-journal-title>
<issn>0121-0319</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-03192020000200008</article-id>
<article-id pub-id-type="doi">10.18273/revmed.v33n2-2020007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Manejo de la terapia anticoagulante durante el embarazo]]></article-title>
<article-title xml:lang="en"><![CDATA[Management of anticoagulant therapy during pregnancy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durán-Morales]]></surname>
<given-names><![CDATA[María Angélica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ariza-Parra]]></surname>
<given-names><![CDATA[Edwin J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Colonia-Toro]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad CES. Medellín. Antioquia. Colombia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia IPS Universitaria León XIII ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad CES Hospital General de Medellín ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>65</fpage>
<lpage>73</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-03192020000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-03192020000200008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-03192020000200008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El embarazo se asocia con 5 a 10 veces mayor riesgo de enfermedad tromboembólica venosa, convirtiéndose en un escenario particular y complejo para la anticoagulación dada la necesidad de seguridad fetal y limitada representación en estudios de eficacia disponibles. Durante la gestación existen tres principales situaciones clínicas: la enfermedad tromboembólica venosa sin factor de riesgo precipitante, el síndrome antifosfolípido y las portadoras de válvulas mecánicas protésicas; todas con un alto riesgo de complicaciones materno-fetales, por lo que es vital conocer los anticoagulantes disponibles para cada patología, su evidencia científica, eventos adversos y características farmacológicas con el fin de realizar el mejor abordaje terapéutico y disminuir complicaciones asociadas. El objetivo es describir los avances de los anticoagulantes en escenarios clínicos de mayor impacto antes de la concepción, durante el embarazo y postparto y servir de herramienta con el fin de realizar el mejor abordaje terapéutico y disminuir complicaciones asociadas. MÉD.UIS.2020;33(2):65-73.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Pregnancy is associated with a 5 to 10-fold increased risk of venous thromboembolic disease, making it a complex setting for anticoagulation, given the need for fetal safety and limited representation in available efficacy studies. During pregnancy there are three main clinical situations: venous thromboembolic disease without a precipitating risk factor, antiphospholipid syndrome and prosthetic mechanical valve carriers; all with a high risk of maternal-fetal complications, so it is vital to know the anticoagulants available for each pathology, their scientific evidence, adverse events and pharmacological characteristics in order to perform the best therapeutic approach and reduce associated complications. The objective is to describe the advances of anticoagulants in clinical scenarios of greater impact before conception, during pregnancy and postpartum and to serve as a tool in order to carry out the best therapeutic approach and reduce associated complications. MÉD.UIS.2020;33(2):65-73.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Embarazo]]></kwd>
<kwd lng="es"><![CDATA[Anticoagulantes]]></kwd>
<kwd lng="es"><![CDATA[Prótesis valvulares cardíacas]]></kwd>
<kwd lng="es"><![CDATA[Síndrome antifosfolípido]]></kwd>
<kwd lng="es"><![CDATA[Tromboembolia]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Anticoagulant]]></kwd>
<kwd lng="en"><![CDATA[Mechanical prosthetic valves]]></kwd>
<kwd lng="en"><![CDATA[Antiphospholipid syndrome]]></kwd>
<kwd lng="en"><![CDATA[Thrombosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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