<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0807</journal-id>
<journal-title><![CDATA[Revista de la Universidad Industrial de Santander. Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Univ. Ind. Santander. Salud]]></abbrev-journal-title>
<issn>0121-0807</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-08072017000100029</article-id>
<article-id pub-id-type="doi">10.18273/revsal.v49n1-2017003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Polimorfismo S19W (Ser19Ter) de la APOA5 y su relación con la hipertrigliceridemia en una población de Colombia]]></article-title>
<article-title xml:lang="en"><![CDATA[S19W polymorphism (Ser19Ter) of APOA5 and its relationship with hypertriglyceridemia in a Colombian population]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mantilla M]]></surname>
<given-names><![CDATA[Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo P]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez F]]></surname>
<given-names><![CDATA[Viviana L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas C]]></surname>
<given-names><![CDATA[Clara I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rondón G]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Industrial de Santander  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Santander  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<volume>49</volume>
<numero>1</numero>
<fpage>29</fpage>
<lpage>35</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-08072017000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-08072017000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-08072017000100029&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Las enfermedades cardiovasculares (ECV) son responsables del 29,69% de las muertes en Colombia. Se ha encontrado la hipertrigliceridemia, en diversos estudios como factor de riesgo independiente para la ECV. El polimorfismo S19W (Ser19Ter) de la ApoA5 se ha asociado en algunas poblaciones con la hipertrigliceridemia. Sin embargo, en Colombia esto ha sido poco estudiado.  Objetivo:  Estimar la asociación entre el polimorfismo S19W y la hipertrigliceridemia en población colombiana.  Metodología:  Estudio tipo Corte Transversal, con 400 individuos provenientes de Bucaramanga, Colombia. Se cuantificó los TAG y se genotipificaron mediante la técnica de SNaPshot y mini secuenciación. Los resultados fueron analizados utilizando el software de análisis genético Arlequín 3.5.1.2.  Resultados:  El polimorfismo S19W (Ser19Ter) mostró tres perfiles, CC, GG y CG. El polimorfismo S19W se caracterizó tanto en afectados como en no afectados, mostrando que no existen diferencias significativas en esta distribución cuando se comparan los dos grupos.  Discusión:  Diversos mecanismos se han propuesto para sustentar la hipertrigliceridemia como un factor de riesgo para ECV, entre los que se cuenta la APOA5. El estudio comprobó que la población estudiada se encuentra en equilibrio de Hardy Weinberg y al genotipo CC como el más frecuente. Los genotipos GG y el GC presentaron valores significativos en el grupo de sujetos afectados, (p&lt;0,01 y p=0,03; respectivamente). Se demostró la existencia de una estrecha relación entre el polimorfismo Ser19Trp y la hipertrigliceridemia (p&lt;0,01).  Conclusión:  Se pudo demostrar la existencia de una relación entre el polimorfismo Ser19Trp de la Apo A5 con los niveles elevados de TAG (p&lt;0,01).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Cardiovascular diseases (CVD) are responsible for 29.69% of the deaths in Colombia. Several studies have shown that hypertriglyceridemia is an independent risk factor for CVD. ApoA5 gene S19W (Ser19Ter) polymorphism has been associated with hypertriglyceridemia in some populations; however, their influence in Colombia is unknown.  Objective:  To determine the relationship between S19W polymorphism and hypertriglyceridemia in Colombian population.  Methodology:  Transversal crossover Studio, included a total of 400 individuals. TAG was quantified and genotyped using the technique SnapShot and mini sequencing. The results were analyzed using genetic analysis software Arlequin 3.5.1.2.  Results: S19W (Ser19Ter) polymorphism showed three profiles, CC, GG and CG. The S19W polymorphism was characterized both affected and not affected. There wasn´t significant differences in the distribution when the two groups are compared.  Discussion:  Various mechanisms have been proposed to support hypertriglyceridemia as a risk factor for CVD, including the APOA5 counted. The study found that the study population is in Hardy Weinberg and CC genotype as the most frequent. The GG and GC genotypes showed significant values in the group of affected subjects (p = 0.002 and 0.03). It demonstrated the existence of a close relationship between the Ser19Trp polymorphism and hypertriglyceridemia (p&lt;0,01).  Conclusion:  It was possible to demonstrate the existence of a relationship between polymorphism Ser19Trp of ApoA5 with elevated levels of TAG (p&lt;0,01).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Polimorfismo genético]]></kwd>
<kwd lng="es"><![CDATA[hipertrigliceridemia]]></kwd>
<kwd lng="es"><![CDATA[cardiopatía isquémica]]></kwd>
<kwd lng="es"><![CDATA[Apo A.]]></kwd>
<kwd lng="en"><![CDATA[Cardiovascular disease]]></kwd>
<kwd lng="en"><![CDATA[polymorphism genetic]]></kwd>
<kwd lng="en"><![CDATA[Hypertriglyceridemia]]></kwd>
<kwd lng="en"><![CDATA[Cardiovascular Diseases]]></kwd>
<kwd lng="en"><![CDATA[APOA5 protein]]></kwd>
<kwd lng="en"><![CDATA[human]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<source><![CDATA[Análisis de la situación de salud, Colombia 2013]]></source>
<year>2014</year>
<page-range>37-50</page-range><publisher-name><![CDATA[Ministerio de Salud y Protección Social]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Molecular genetics of coronary artery disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Opin Cardiol]]></source>
<year>2005</year>
<volume>20</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>182-8</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evidence that triglycerides are an independent coronary heart disease risk factor]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cullen]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Cardiol]]></source>
<year>2000</year>
<volume>86</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>943-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genetic and environmental influences on serum lipid levels in twins]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heller]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[de Faire]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Pedersen]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Dahlen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[McClearn]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>1993</year>
<volume>328</volume>
<page-range>1150-6</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Korn]]></surname>
<given-names><![CDATA[ED]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>1955</year>
<volume>215</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-14</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pennacchio]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Olivier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hubacek]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Cox]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Fruchart]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2001</year>
<volume>294</volume>
<numero>5540</numero>
<issue>5540</issue>
<page-range>169-73</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van der Vliet]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apolipoprotein A-V a novel apolipoprotein associated with an early phase of liver regeneration]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Sammels]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Leegwater]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Levels]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Reitsma]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Boers]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>2001</year>
<volume>276</volume>
<numero>48</numero>
<issue>48</issue>
<page-range>44512-20</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ong]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[CQ]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Tso]]></surname>
<given-names><![CDATA[AW]]></given-names>
</name>
<name>
<surname><![CDATA[Tam]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese]]></article-title>
<collab>et al</collab>
<source><![CDATA[Clin Endocrinol (Oxf)]]></source>
<year>2011</year>
<volume>74</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>206-13</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Henneman]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Schaap]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Havekes]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Rensen]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Frants]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[van Tol]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Atherosclerosis]]></source>
<year>2007</year>
<volume>193</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>129-34</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pennacchio]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Olivier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hubacek]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Krauss]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum Mol Genet]]></source>
<year>2002</year>
<volume>11</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>3031-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the apolipoprotein A5 gene]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bode]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lippe]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Beil]]></surname>
<given-names><![CDATA[FU]]></given-names>
</name>
<name>
<surname><![CDATA[Mann]]></surname>
<given-names><![CDATA[WA]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur J Med Res]]></source>
<year>2011</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>79-84</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sóter]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[KB]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Carvalho Md]]></surname>
</name>
<name>
<surname><![CDATA[Pinheiro]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Bosco]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mol Biol]]></article-title>
<collab>et al -1131T C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patient</collab>
<source><![CDATA[Rep]]></source>
<year>2012</year>
<volume>39</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>7541-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Olivier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Cole]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gau]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<source><![CDATA[Genomics]]></source>
<year>2004</year>
<volume>83</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>912-23</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Apolipoprotein A5 IVS3 + 476A allelic variant associates with increased triglyceride levels confers risk for development of metabolic syndrome in Hungarians]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kisfali]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mohas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Maasz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hadarits]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Marko]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Horvatovich]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Circ J]]></source>
<year>2008</year>
<volume>72</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>40-3</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Gene-gene interaction between APOA5 and USF1 two candidate genes for the metabolic syndrome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singmann]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Baumert]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Herder]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Meisinger]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Holzapfel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Klopp]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Obes Facts]]></source>
<year>2009</year>
<volume>2</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>235-42</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Arlequin suite ver 3 5: a new series of programs to perform population genetics analyses under Linux and Windows]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Excoffier]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lischer]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol Ecol Resour]]></source>
<year>2010</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>564-7</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Stone]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ballantyne]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bittner]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Criqui]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Ginsberg]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Triglycerides and cardiovascular disease a scientific statement from the American Heart Association]]></article-title>
<source><![CDATA[Circulation]]></source>
<year>2011</year>
<volume>123</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>2292-333</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Triglycerides and cardiovascular disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nordestgaard]]></surname>
<given-names><![CDATA[BG]]></given-names>
</name>
<name>
<surname><![CDATA[Varbo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2014</year>
<volume>384</volume>
<numero>9943</numero>
<issue>9943</issue>
<page-range>626-35</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Atherogenic role of elevated CE transfer from HDL to VLDL (1) and dense LDL in type 2 diabetes impact of the degree of triglyceridemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guérin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Le Goff]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Lassel]]></surname>
<given-names><![CDATA[TS]]></given-names>
</name>
<name>
<surname><![CDATA[Van Tol]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Steiner]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chapman]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Arterioscler Thromb Vasc Biol]]></source>
<year>2001</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>282-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[New perspectives on atherogenesis role of abnormal triglyceride-rich lipoprotein metabolism]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ginsberg]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
</person-group>
<source><![CDATA[Circulation]]></source>
<year>2002</year>
<volume>106</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>2137-42</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical practiceHypertriglyceridemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brunzell]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2007</year>
<volume>357</volume>
<page-range>1009-17</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FER(HDL) but is not a risk factor for coronary artery disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[KW]]></given-names>
</name>
<name>
<surname><![CDATA[Ayyobi]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Frohlich]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hill]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<source><![CDATA[Atherosclerosis]]></source>
<year>2004</year>
<page-range>176</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ajjemami]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ouatou]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Charoute]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Fakiri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rhaissi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Benrahma]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Diabetes Metab Disord]]></source>
<year>2015</year>
<volume>14</volume>
<page-range>29</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Castro-Orós]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Cenarro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Tejedor]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Baila- Rueda]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Mateo-Gallego]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lamiquiz-Moneo]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Circ Cardiovasc Genet]]></source>
<year>2014</year>
<volume>7</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>814-21</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Influences of APOA5 variants on plasma triglyceride levels in Uyghur population]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One]]></source>
<year>2014</year>
<volume>9</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>e110258</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mattei]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Demissie]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tucker]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Ordova]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[J Nutr]]></source>
<year>2009</year>
<volume>139</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2301-8</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[In vivo characterization of human APOA5 haplotypes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahituv]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Akiyama]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chapman-Helleboid]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fruchart]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pennacchio]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<source><![CDATA[Genomics]]></source>
<year>2007</year>
<volume>90</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>674-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The influence of the S19W SNP of the APOA5 gene on triglyceride levels in southern Brazil Interactions with the APOE gene, sex and menopause status]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Andrade]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Maluf]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Schuch]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Voigt]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Barros]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Lucatelli]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
</person-group>
<source><![CDATA[Nutr Metab Cardiovasc Dis]]></source>
<year>2011</year>
<volume>21</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>584-90</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Common polymorphisms of the peroxisome proliferator-activated receptor- (Pro12Ala) and peroxisome proliferator-activated receptor-? coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hsieh]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Tien]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Tu]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
<name>
<surname><![CDATA[Hsiao]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Metabolism]]></source>
<year>2010</year>
<volume>59</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1139-44</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genetic and phenotipic variation.In Principles of population genetic]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartl]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<source><![CDATA[Sinauer Associates Publishers Sunderland. 4ª Ed. Massachusetts: Sinauer associates]]></source>
<year>2007</year>
<page-range>4 - 38</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Determination of the functionality of common APOA5 polymorphisms]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talmud]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Palmen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Putt]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Lins]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Humphries]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>2005</year>
<volume>280</volume>
<numero>31</numero>
<issue>31</issue>
<page-range>28215-20</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schaap]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Rensen]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Voshol]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Vrins]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL- TG hydrolysis]]></article-title>
<collab>van der Vliet HN.Chamuleau RA</collab>
<source><![CDATA[J Biol Chem]]></source>
<year>2004</year>
<page-range>279</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talmud]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hawe]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Olivier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum Mol Genet]]></source>
<year>2002</year>
<volume>11</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>3039-46</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Apolipoprotein A-V heparin interactions implications for plasma lipoprotein metabolism]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lookene]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beckstead]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Nilsson]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Olivecrona]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[RO]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>2005</year>
<page-range>280</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nilsson]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Lookene]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beckstead]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Gliemann]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[RO]]></given-names>
</name>
<name>
<surname><![CDATA[Olivecrona]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochemistry]]></source>
<year>2007</year>
<volume>46</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3896-904</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Glycosylphosphatidylinositol- anchored high density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Beigneux]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Davies]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Gin]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Weinstein]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Farber]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Qiao]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell Metab]]></source>
<year>2007</year>
<page-range>5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
