<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0807</journal-id>
<journal-title><![CDATA[Revista de la Universidad Industrial de Santander. Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Univ. Ind. Santander. Salud]]></abbrev-journal-title>
<issn>0121-0807</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-08072025000100021</article-id>
<article-id pub-id-type="doi">10.18273/saluduis.57.e:25v57a27</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Metabolic and Genetic Alterations Induced by High-Fat and High-Glucose Diets in Wistar Rats]]></article-title>
<article-title xml:lang="es"><![CDATA[Alteraciones metabólicas y genéticas inducidas por dieta alta en grasa y glucosa en ratas Wistar]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giorgi-Ortiz]]></surname>
<given-names><![CDATA[Jennifer Melissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Angel-Martin]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ocazionez]]></surname>
<given-names><![CDATA[Raquel Elvira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Castellanos]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Industrial de Santander  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>57</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-08072025000100021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-08072025000100021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-08072025000100021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Diet-induced obesity (DIO) in laboratory rats serves as a pathophysiological model for obesity research, yet remains poorly understood. Different types of diets, varying in their concentrations of carbohydrates, fats, and proteins, can induce distinct anatomical, metabolic, and genetic changes in Wistar rats.  Objective: This study aims to identify the bodily, metabolic, and genetic changes resulting from different ad libitum diets in each sex separately.  Methodology: Sixty-four Wistar rats were divided into four groups: Standard Diet (SD), Glucose Standard Diet (GSD), High Fat Diet (HFD), and Glucose High Fat Diet (GHFD). Pre- and post-measurements of weight, snout-tail length, and serum levels (glucose, cholesterol, triglycerides, high-density lipoprotein (HDL)) were taken. Post-sacrifice, liver, pancreas, visceral, brown, subcutaneous, and skeletal muscle adipose tissue samples were extracted. Gene expression of insulin receptor (INSR), fatty acid synthase (FASN), peroxisome proliferator-activated receptor gamma (PPAR&#947;), and lipoprotein lipase (LPL) in subcutaneous adipose tissue was assessed by real-time PCR.  Results: The GSD group exhibited significant increases in body mass, body mass index, and weights of visceral and subcutaneous adipose tissue. Higher cholesterol levels were observed in the HFD group, while GHFD induced the most significant increase in blood glucose and lipid profiles.  Conclusion: The GSD, HFD, and GHFD diets simulate high-fat and high-sugar eating patterns, resulting in substantial increases in body mass and adipose tissue in the GSD group. The GHFD diet elevates blood glucose and lipid levels the most, while promoting lipogenic gene expression (FASN, LPL) and reducing the expression of insulin receptors (INSR) and PPARy, thereby inducing insulin resistance and obesity.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La obesidad inducida por dieta (DIO) en ratas de laboratorio sirve como un modelo fisiopatológico para la investigación en obesidad, aunque su estudio aún es limitado. Diferentes tipos de dietas, con variaciones en las concentraciones de carbohidratos, grasas y proteínas, pueden inducir cambios anatómicos, metabólicos y genéticos distintos en ratas Wistar.  Objetivo: Este estudio busca identificar los cambios corporales, metabólicos y genéticos resultantes de diferentes dietas ad libitum en cada sexo por separado.  Metodología: Sesenta y cuatro ratas Wistar fueron divididas en cuatro grupos: Dieta Estándar (SD), Dieta Estándar con Glucosa (GSD), Dieta Alta en Grasas (HFD) y Dieta Alta en Grasas con Glucosa (GHFD). Se realizaron mediciones pre y post de peso, longitud hocico-cola y niveles séricos (glucosa, colesterol, triglicéridos, lipoproteína de alta densidad (HDL)). Tras el sacrificio, se extrajeron muestras de hígado, páncreas, tejido adiposo visceral, marrón, subcutáneo y músculo esquelético. Se evaluó la expresión génica del receptor de insulina (INSR), sintasa de ácidos grasos (FASN), receptor gamma activado por proliferadores de peroxisomas (PPAR&#947;) y lipoproteína lipasa (LPL) en tejido adiposo subcutáneo mediante PCR en tiempo real.  Resultados: El grupo GSD mostró incrementos significativos en la masa corporal, índice de masa corporal y pesos del tejido adiposo visceral y subcutáneo. En el grupo HFD se observaron niveles más altos de colesterol, mientras que la dieta GHFD indujo el mayor aumento en glucosa sanguínea y perfiles lipídicos.  Conclusión: Las dietas GSD, HFD y GHFD simulan patrones de alimentación altos en grasa y azúcar, resultando en aumentos considerables de masa corporal y tejido adiposo en el grupo GSD. La dieta GHFD eleva en mayor medida los niveles de glucosa y lípidos en sangre, al tiempo que promueve la expresión de genes lipogénicos (FASN, LPL) y reduce la expresión de receptores de insulina (INSR) y PPARy, induciendo resistencia a la insulina y obesidad.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Obesity]]></kwd>
<kwd lng="en"><![CDATA[Insulin Resistance]]></kwd>
<kwd lng="en"><![CDATA[Hypercholesterolemia]]></kwd>
<kwd lng="en"><![CDATA[Genes]]></kwd>
<kwd lng="en"><![CDATA[Diet]]></kwd>
<kwd lng="es"><![CDATA[Obesidad]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a la Insulina]]></kwd>
<kwd lng="es"><![CDATA[Hipercolesterolemia: Genes: Dieta]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>World Health Organization: WHO</collab>
<source><![CDATA[World Obesity Day 2022 - Accelerating action to stop obesity]]></source>
<year>2022</year>
<publisher-name><![CDATA[World Health Organization]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ángel-Martín]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vaillant]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno-Castellanos]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Daily Consumption of Golden Berry (Physalis peruviana) Has Been Shown to Halt the Progression of Insulin Resistance and Obesity in Obese Rats with Metabolic Syndrome]]></article-title>
<source><![CDATA[Nutrients]]></source>
<year>2024</year>
<volume>16</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>365</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Klein]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gastaldelli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Yki-Järvinen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Scherer]]></surname>
<given-names><![CDATA[PE.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Why does obesity cause diabetes?]]></article-title>
<source><![CDATA[Cell Metabolism]]></source>
<year>2022</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11-20</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Udomkasemsab]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Prangthip]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High fat diet for induced dyslipidemia and cardiac pathological alterations in Wistar rats compared to Sprague Dawley rats]]></article-title>
<source><![CDATA[Clin Investig Arterioscler]]></source>
<year>2019</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>56-62</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gijsen]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Kotzé-Hôrstmann]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rat models of diet-induced obesity and metabolic dysregulation: current trends, shortcomings and considerations for future research]]></article-title>
<source><![CDATA[Obes Res Clin Pract]]></source>
<year>2023</year>
<volume>17</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>449-57</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption]]></article-title>
<source><![CDATA[Biogerontology]]></source>
<year>2023</year>
<volume>24</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>235-44</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arifin]]></surname>
<given-names><![CDATA[WN]]></given-names>
</name>
<name>
<surname><![CDATA[Zahiruddin]]></surname>
<given-names><![CDATA[WM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sample Size Calculation in Animal Studies Using Resource Equation Approach]]></article-title>
<source><![CDATA[Malays J Med Sci]]></source>
<year>2017</year>
<volume>24</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>101-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Moura]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Reis]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Da Conceição]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[De Oliveira]]></surname>
<given-names><![CDATA[CMN]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[De Oliveira]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diet-induced obesity in animal models: points to consider and influence on metabolic markers]]></article-title>
<source><![CDATA[Diabetol Metab Syndr]]></source>
<year>2021</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergen]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
<name>
<surname><![CDATA[Mersmann]]></surname>
<given-names><![CDATA[HJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative Aspects of Lipid Metabolism: Impact on Contemporary Research and Use of Animal Models]]></article-title>
<source><![CDATA[J Nutr]]></source>
<year>2005</year>
<volume>135</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2499-502</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kleiber]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Body size and metabolic rate]]></article-title>
<source><![CDATA[Physiol Rev]]></source>
<year>1947</year>
<volume>27</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>511-41</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LeBlanc]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Labrie]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A possible role for palatability of the food in diet-induced thermogenesis]]></article-title>
<source><![CDATA[Int J Obes]]></source>
<year>1997</year>
<volume>21</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1100-3</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wondmkun]]></surname>
<given-names><![CDATA[YT.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications]]></article-title>
<source><![CDATA[Diabetes Metabo Syndr Obes]]></source>
<year>2020</year>
<volume>13</volume>
<page-range>3611-6</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Darwish]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Gouda]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Almutairi]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Elshikh]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Morcos]]></surname>
<given-names><![CDATA[GN.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PPARG expression patterns and correlations in obesity]]></article-title>
<source><![CDATA[J King Saud Univ Sci]]></source>
<year>2022</year>
<volume>34</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>102116</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schleinitz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Klöting]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Körner]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Berndt]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Reichenbächer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tönjes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat Depot-Specific mRNA expression]]></article-title>
<source><![CDATA[Obesity]]></source>
<year>2010</year>
<volume>18</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1218-25</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kusunoki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tsutsumi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Sato]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipoprotein lipase and obesity]]></article-title>
<source><![CDATA[Health]]></source>
<year>2012</year>
<volume>04</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1405-12</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sasidharan]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Joseph]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Anandakumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Venkatesan]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Ariyattu]]></surname>
<given-names><![CDATA[CN]]></given-names>
</name>
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders]]></article-title>
<source><![CDATA[BioMed Res Int]]></source>
<year>2013</year>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jia]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[RX]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[JJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dyslipidemia in rat fed with high-fat diet is not associated with PC-SK9-LDL-receptor pathway but ageing]]></article-title>
<source><![CDATA[J Geriatr Cardiol]]></source>
<year>2013</year>
<volume>10</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>361-8</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kahn]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Del Prato]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2014</year>
<volume>383</volume>
<numero>9922</numero>
<issue>9922</issue>
<page-range>1068-83</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lackey]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Lazaro]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Li P Johnson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hernandez-Carretero]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Weber]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Vorobyova]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Tsukomoto]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Osborn]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of dietary fat in obesity-induced insulin resistance]]></article-title>
<source><![CDATA[AJP Endocrinol Metab]]></source>
<year>2016</year>
<volume>311</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>989-97</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nakagawa]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zharikov]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tuttle]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Short]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Glushakova]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A causal role for uric acid in fructose-induced metabolic syndrome]]></article-title>
<source><![CDATA[Am J Physiol. Renal Physiol]]></source>
<year>2006</year>
<volume>290</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>F625-31</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salih]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Nallasamy P Muniyandi P Periyasami V Carani]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Retracted: Genistein improves liver function and attenuates nonalcoholic fatty liver disease in a rat model of insulin resistance]]></article-title>
<source><![CDATA[J Diabetes]]></source>
<year>2009</year>
<volume>1</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>278-87</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shih]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[JB.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats]]></article-title>
<source><![CDATA[J Ethnopharmacol]]></source>
<year>2009</year>
<volume>123</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>82-90</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zaman]]></surname>
<given-names><![CDATA[MQ]]></given-names>
</name>
<name>
<surname><![CDATA[Leray]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bloc'h]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Thorin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ouguerram]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipid profile and insulin sensitivity in rats fed with high-fat or high-fructose diets]]></article-title>
<source><![CDATA[Br J Nutr]]></source>
<year>2011</year>
<volume>106</volume>
<numero>S1</numero>
<issue>S1</issue>
<page-range>S206-10</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Moura]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[De Oliveira]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Stevanato]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rostom]]></surname>
<given-names><![CDATA[MA.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols]]></article-title>
<source><![CDATA[Br J Nutr]]></source>
<year>2008</year>
<volume>101</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1178-84</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Otunola]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Oloyede]]></surname>
<given-names><![CDATA[OB]]></given-names>
</name>
<name>
<surname><![CDATA[Oladiji]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
<name>
<surname><![CDATA[Afolayan]]></surname>
<given-names><![CDATA[AA.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female Wistar rats]]></article-title>
<source><![CDATA[Afr. J Biochem Res]]></source>
<year>2010</year>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bhandari]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar V Khanna]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Prasad]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of high-fat diet-induced obesity on cardiovascular toxicity in wistar albino rats]]></article-title>
<source><![CDATA[Hum Exp Toxicol]]></source>
<year>2010</year>
<volume>30</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1313-21</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González P Lozano P Ros]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Solano]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2023</year>
<volume>24</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>9352</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wondmkun]]></surname>
<given-names><![CDATA[YT.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications]]></article-title>
<source><![CDATA[Diab Met Synd Obes]]></source>
<year>2020</year>
<volume>13</volume>
<page-range>3611-6</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boqué]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Campión]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Paternain]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[García-Díaz]]></surname>
<given-names><![CDATA[DF]]></given-names>
</name>
<name>
<surname><![CDATA[Galarraga]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Portillo]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of dietary macronutrient composition on adiposity and cellularity of different fat depots in Wistar rats]]></article-title>
<source><![CDATA[J Physiol Biochem]]></source>
<year>2009</year>
<volume>65</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>387-95</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
