<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0807</journal-id>
<journal-title><![CDATA[Revista de la Universidad Industrial de Santander. Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Univ. Ind. Santander. Salud]]></abbrev-journal-title>
<issn>0121-0807</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-08072025000100042</article-id>
<article-id pub-id-type="doi">10.18273/saluduis.57.e:25v57r04</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Experimental conditions for assessing anti-Trypanosoma cruzi (epimastigotes) activity in vitro: A scoping review]]></article-title>
<article-title xml:lang="es"><![CDATA[Condiciones experimentales para evaluar la actividad anti- Trypanosoma cruzi (epimastigotes) in vitro: una revisión de alcance]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias]]></surname>
<given-names><![CDATA[María-Helena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Jhindy-Tatiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garavito]]></surname>
<given-names><![CDATA[Giovanny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Ciencias Departamento de Farmacia]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>57</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-08072025000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-08072025000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-08072025000100042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Chagas disease, caused by Trypanosoma cruzi, affects 6-8 million people worldwide. Current treatments raise safety concerns. In vitro phenotypic screening variability in parasite strains, life cycle stages, and experimental conditions hinders result comparisons impeding new treatment development.  Objective: To identify experimental conditions in T cruzi epimastigote model and propose criteria for harmonizing experimental procedures.  Methodology: Analysis of 63 research articles (106 assays) from indexed journals (2008-2023), on antiparasitic activity against epimastigotes.  Results: Studies use diverse evolutionary forms, primarily amastigotes and epimastigotes. Despite advancements in culture techniques, establishing uniform conditions remains unfeasible. We propose focusing on specific parasite forms.  Conclusions: To harmonize experimental conditions, we propose standardizing: strains, culture medium (and enrichment), incubation parameters (temperature and medium replacement frequency). Similarly, the pharmacological test conditions such as infecting inoculum concentration, culture well plate specifications, treatment exposure time, and parasite quantification method-facilitating result comparison and accelerating the development of new treatments.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La enfermedad de Chagas, causada por Trypanosoma cruzi, afecta entre 6 y 8 millones de personas en todo el mundo. Los tratamientos actuales plantean problemas de seguridad. La variabilidad del tamizaje fenotípico in vitro en cuanto a cepas del parásito, estadios del ciclo vital y condiciones experimentales dificultan la comparación de resultados e impiden el desarrollo de nuevos tratamientos.  Objetivo: Identificar condiciones experimentales críticas en el modelo de epimastigotes de T. cruzi y proponer criterios para armonizar los procedimientos experimentales.  Metodología: Análisis de 63 artículos de investigación (106 ensayos) de revistas indexadas (2008-2023), sobre actividad antiparasitaria frente a epimastigotes.  Resultados: Los estudios utilizan diversas formas evolutivas, principalmente amastigotes y epimastigotes. A pesar de avances en las técnicas de cultivo, establecer condiciones uniformes para todos los estadios sigue siendo inviable. Proponemos focalizar formas parasitarias específicas.  Conclusiones: Para armonizar condiciones experimentales, proponemos optimizar: cepas, medio de cultivo (y enriquecimiento), parámetros de incubación (temperatura y frecuencia de sustitución del medio). Del mismo modo, las condiciones de prueba farmacológica, como concentración del inóculo infectante, especificaciones de placa de cultivo, tiempo de exposición al tratamiento y método de cuantificación del parásito, facilitan comparación de resultados y aceleran el desarrollo de nuevos tratamientos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Trypanosoma cruzi]]></kwd>
<kwd lng="en"><![CDATA[Parasitic Sensitivity Tests]]></kwd>
<kwd lng="en"><![CDATA[Chagas Disease]]></kwd>
<kwd lng="en"><![CDATA[Scoping Review]]></kwd>
<kwd lng="en"><![CDATA[Neglected Tropical Diseases]]></kwd>
<kwd lng="en"><![CDATA[Drug Discovery]]></kwd>
<kwd lng="en"><![CDATA[In Vitro Techniques]]></kwd>
<kwd lng="es"><![CDATA[Trypanosoma cruzi]]></kwd>
<kwd lng="es"><![CDATA[Pruebas de Sensibilidad Parasitaria]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Chagas]]></kwd>
<kwd lng="es"><![CDATA[Revisión de Alcance]]></kwd>
<kwd lng="es"><![CDATA[Enfermedades Desatendidas]]></kwd>
<kwd lng="es"><![CDATA[Descubrimiento de Fármacos]]></kwd>
<kwd lng="es"><![CDATA[Técnicas In Vitro]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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