<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-246X</journal-id>
<journal-title><![CDATA[Revista Facultad de Odontología Universidad de Antioquia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Fac Odontol Univ Antioq]]></abbrev-journal-title>
<issn>0121-246X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Antioquia ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-246X2017000100408</article-id>
<article-id pub-id-type="doi">10.17533/udea.rfo.v28n2a10</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[PATHOGENESIS OF DENTAL FLUOROSIS: BIOCHEMICAL AND CELLULAR MECHANISMS]]></article-title>
<article-title xml:lang="es"><![CDATA[PATOGÉNESIS DE LA FLUOROSIS DENTAL: MECANISMOS BIOQUÍMICOS Y CELULARES]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[CASTIBLANCO RUBIO]]></surname>
<given-names><![CDATA[GINA ALEJANDRA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[MARTIGNON]]></surname>
<given-names><![CDATA[STEFANIA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[CASTELLANOS PARRA]]></surname>
<given-names><![CDATA[JAIME EDUARDO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[MEJÍA NARANJO]]></surname>
<given-names><![CDATA[WILSON ALFONSO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad El Bosque  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad El Bosque  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad El Bosque  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>28</volume>
<numero>2</numero>
<fpage>408</fpage>
<lpage>421</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-246X2017000100408&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-246X2017000100408&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-246X2017000100408&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract. The mechanisms involved in the development of dental fluorosis are still unknown. The development of in vivo and in vitro models using biologically relevant concentrations of fluoride for the emergence of fluorosis has allowed suggesting hypotheses that contribute to the understanding of the mechanisms that produce this defect in enamel development, with high prevalence in Colombia. This topic review presents an update on the normal mechanisms of the formation of enamel and how they are affected by exposure to high concentrations of fluoride. This is a thorough review of the deleterious effects of fluoride on the cells and the extracellular matrix, especially during the maturation stage, resulting in a delay of the removal of the protein matrix of amelogenins, as well as the appearance of mottled enamel-a characteristic of dental fluorosis. Finally, it shows the perspectives of the study of this defect in enamel development from biochemistry and cellular and molecular biology.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN. Los mecanismos involucrados en el desarrollo de la fluorosis dental aún no se conocen a cabalidad. El desarrollo de modelos in vivo e in vitro que utilizan concentraciones de fluoruro biológicamente relevantes para la aparición de fluorosis ha permitido el planteamiento de hipótesis que aportan cada vez más al conocimiento de los mecanismos que generan este defecto del desarrollo del esmalte, de alta prevalencia en Colombia. Esta revisión presenta una actualización sobre los mecanismos normales de la formación del esmalte y cómo estos se ven afectados por la exposición a altas concentraciones de fluoruro. Se presenta una revisión en detalle de los efectos deletéreos del fluoruro sobre las células y sobre la matriz extracelular, especialmente durante la etapa de maduración, que tendrán como consecuencia el retraso de la remoción de la matriz proteica de amelogeninas y se traducirá en la apariencia de esmalte moteado, característica de la fluorosis dental. Por último, se muestran las perspectivas del estudio de este defecto del desarrollo del esmalte desde la bioquímica y la biología celular y molecular.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[dental fluorosis]]></kwd>
<kwd lng="en"><![CDATA[amelogenesis]]></kwd>
<kwd lng="en"><![CDATA[amelogenin]]></kwd>
<kwd lng="en"><![CDATA[dental enamel proteins]]></kwd>
<kwd lng="es"><![CDATA[fluorosis dental]]></kwd>
<kwd lng="es"><![CDATA[amelogénesis]]></kwd>
<kwd lng="es"><![CDATA[amelogenina]]></kwd>
<kwd lng="es"><![CDATA[proteínas del esmalte dental]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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