<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-246X</journal-id>
<journal-title><![CDATA[Revista Facultad de Odontología Universidad de Antioquia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Fac Odontol Univ Antioq]]></abbrev-journal-title>
<issn>0121-246X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Antioquia ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-246X2024000100073</article-id>
<article-id pub-id-type="doi">10.17533/udea.rfo.v36n1a7</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Effects and clinical application of cannabinoids for the treatment of periodontal disease: a systematic review]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectos y aplicación clínica de los cannabinoides para el tratamiento de enfermedad periodontal: revisión sistemática]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Gutiérrez]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hoyos-Castrillón]]></surname>
<given-names><![CDATA[Yuliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcés-Londoño]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jaimes-Ríos]]></surname>
<given-names><![CDATA[Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<fpage>73</fpage>
<lpage>84</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-246X2024000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-246X2024000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-246X2024000100073&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  cannabinoids have a wide range of biological effects and are currently used for therapeutic purposes in modern medicine. The objective was to determine the effects and clinical application of cannabinoids as a therapeutic alternative for periodontal disease.  Methods:  we conducted a systematic review following the Cochrane manual for systematic reviews' recommendations to address the following inquiries: 1) What is the impact of non-surgical therapy with cannabidiol compared to conventional non-surgical therapy on the level of insertion in patients with periodontal disease? 2) What are the potential biological and microbiological effects of cannabinoids in the treatment of periodontal disease? The primary outcome was changes in the periodontal attachment level (CAL) and secondary outcomes included changes in probing depth (PD), changes in bleeding on probing (BoP), report of adverse effects and microbiological and biological effects.  Results:  out of 59 potential studies, 26 were excluded in the initial screening, and 33 full-text studies underwent further review. Among these, 13 were excluded for not meeting the selection criteria, resulting in 20 studies included in the qualitative synthesis. Notably, only one highly biased human clinical study was identified. In vitro and animal studies demonstrated that cannabinoids possess bactericidal properties, anti-inflammatory potential, and modulating activity on periodontal bone resorption.  Conclusion:  the available scientific evidence is scarce to recommend the use of cannabis derivatives for the treatment of periodontal disease. Despite promising findings in preclinical studies indicating therapeutic potential, further investigation is required to assess its application in human subjects.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  los cannabinoides tienen una amplia gama de efectos biológicos y actualmente se utilizan con fines terapéuticos en la medicina moderna. El objetivo de esta revisión sistemática fue determinar los efectos y la aplicación clínica de los cannabinoides como alternativa terapéutica para la enfermedad periodontal.  Métodos:  se realizó una revisión sistemática de acuerdo con las recomendaciones del manual Cochrane para revisar sistemáticas para responder a las siguientes preguntas: ¿Cuál es el efecto de la terapia no quirúrgica con cannabidiol en comparación con la terapia no quirúrgica convencional en el nivel de inserción en pacientes con enfermedad periodontal? ¿Cuáles son los efectos biológicos y microbiológicos potenciales de los cannabinoides para el tratamiento de la periodontal?  Resultados:  de un total de 59 estudios potenciales, se excluyeron 26 estudios en el primer filtro y se procedió a revisar 33 estudios en texto completo. Solo se identificó un estudio clínico en humanos con sesgo alto. Los estudios in vitro y en animales demostraron que los cannabinoides tienen un potencial bactericida, antiinflamatorio y modulador de la reabsorción ósea periodontal.  Conclusiones:  no existe suficiente evidencia científica que demuestre que los derivados del cannabis pueden ser implementados en la terapéutica de la enfermedad periodontal. Los estudios preclínicos muestran potencial terapéutico, pero todavía falta por estudiar su aplicación en humanos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[cannabis]]></kwd>
<kwd lng="en"><![CDATA[cannabinoids]]></kwd>
<kwd lng="en"><![CDATA[cannabidiol]]></kwd>
<kwd lng="en"><![CDATA[periodontitis]]></kwd>
<kwd lng="en"><![CDATA[periodontal diseases]]></kwd>
<kwd lng="es"><![CDATA[cannabis]]></kwd>
<kwd lng="es"><![CDATA[cannabinoides]]></kwd>
<kwd lng="es"><![CDATA[canabidiol]]></kwd>
<kwd lng="es"><![CDATA[periodontitis]]></kwd>
<kwd lng="es"><![CDATA[enfermedades periodontales]]></kwd>
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