<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-4004</journal-id>
<journal-title><![CDATA[Vitae]]></journal-title>
<abbrev-journal-title><![CDATA[Vitae]]></abbrev-journal-title>
<issn>0121-4004</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Química Farmacéutica, Universidad de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-40042022000300001</article-id>
<article-id pub-id-type="doi">10.17533/udea.vitae.v29n3a347295</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[The luminescent Chalcones. Its potential use as a luminescent and antitumoral agents]]></article-title>
<article-title xml:lang="en"><![CDATA[Chalconas luminiscentes. Su uso potencial como agentes luminiscentes y antitumorales]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramirez-Tagle]]></surname>
<given-names><![CDATA[Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Soto]]></surname>
<given-names><![CDATA[Leonor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar]]></surname>
<given-names><![CDATA[Carlos A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Echeverria-Echeverria]]></surname>
<given-names><![CDATA[Cesar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Aconcagua Dirección de Investigación y Postgrado ]]></institution>
<addr-line><![CDATA[Vitacura ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Aconcagua Dirección de Investigación y Postgrado ]]></institution>
<addr-line><![CDATA[Vitacura ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad San Sebastián Facultad de Medicina y Ciencia Departamento de Ciencias Biológicas y Químicas]]></institution>
<addr-line><![CDATA[Providencia Santiago]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Atacama Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Copiapó ]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>29</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-40042022000300001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-40042022000300001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-40042022000300001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes:  El carcinoma hepatocelular (CHC) es uno de los cánceres más diagnosticados en todo el mundo. La quimio prevención del CHC se puede lograr utilizando compuestos naturales o sintéticos que reviertan, supriman, detecten o prevengan la progresión del cáncer. Objetivos: En este estudio, se investigó tanto los efectos antiproliferativos como las propiedades luminiscentes de las 2'-hidroxicalconas.  Métodos:  La viabilidad celular se evaluó usando el ensayo colorimétrico (MTT), los ensayos de espectroscopia y los cálculos DFT se usaron para determinar las propiedades luminiscentes de las 2´-hidroxichalconas.  Resultados:  Se observaron efectos citotóxicos sobre las líneas celulares del tipo HepG2 y EA.hy926. Dado que la estructura de la 2´-hidroxichalcona puede ser usada como sonda fluorescente, estos compuestos pueden ser útiles en el diagnóstico del cáncer y la localización del tumor, ya que pueden permitir la observación a través de la fluorescencia y la regresión del tumor durante el tratamiento, por lo que son candidatas potenciales como nuevos agentes anticancerígenos que podrían actuar sobre hepatomas humanos.  Conclusiones:  Este trabajo describe el uso de las 2´-hidroxichalconas como un biomarcador luminiscente específico para células tumorales. También informamos la captación celular de 2'-hidroxicalconas, su distribución celular y los mecanismos que pueden ser responsables de sus efectos citotóxicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  Hepatocellular carcinoma (HCC) is one of the most diagnosed cancers worldwide. Chemoprevention of HCC can be achieved using natural or synthetic compounds that reverse, suppress, detect, or prevent cancer progression. OBJECTIVES: In this study, both the antiproliferative effects and luminescent properties of 2&#8217;-hydroxychalcones were evaluated.  Methods:  Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay, spectroscopy assays, and density functional theory (DFT) calculations were used to determine the luminescent properties of 2´-hydroxychalcones.  Results:  Cytotoxic effects of 2´-hydroxychalcones were observed over the HepG2 and EA.hy926 cells. Since the chalcone moiety could be used as a fluorescent probe, these compounds may be helpful in cancer diagnosis and tumor localization. They may enable tumor observation and regression through the fluorescence during treatment; therefore, the compounds are a potential candidate as novel anticancer agents acting on human hepatomas.  Conclusions:  This report describes the chalcones&#8217; use as a specific luminescent biomarker in tumor cells. We also report the cellular uptake of 2&#8217;-hydroxychalcones, their cellular distribution, and the mechanisms that may be responsible for their cytotoxic effects.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[2&#8217;-hydroxychalcones]]></kwd>
<kwd lng="en"><![CDATA[anticancer agent]]></kwd>
<kwd lng="en"><![CDATA[luminescent biomarker]]></kwd>
<kwd lng="en"><![CDATA[Cytotoxic effects]]></kwd>
<kwd lng="es"><![CDATA[2&#8217;-hidroxichalconas]]></kwd>
<kwd lng="es"><![CDATA[agente anticancerígeno]]></kwd>
<kwd lng="es"><![CDATA[biomarcador luminiscente]]></kwd>
<kwd lng="es"><![CDATA[efectos citotóxicos]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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