<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-4004</journal-id>
<journal-title><![CDATA[Vitae]]></journal-title>
<abbrev-journal-title><![CDATA[Vitae]]></abbrev-journal-title>
<issn>0121-4004</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Química Farmacéutica, Universidad de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-40042024000200002</article-id>
<article-id pub-id-type="doi">10.17533/udea.vitae.v31n2a352429</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models]]></article-title>
<article-title xml:lang="es"><![CDATA[Impacto toxicológico del rabeprazol y evaluación de los efectos tóxicos en los modelos de prueba eucariotas basados en plantas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Islam]]></surname>
<given-names><![CDATA[Muhammad Torequl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iriti]]></surname>
<given-names><![CDATA[Marcello]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Harhar]]></surname>
<given-names><![CDATA[Hicham]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elouafy]]></surname>
<given-names><![CDATA[Youssef]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bhuia]]></surname>
<given-names><![CDATA[Md. Shimul]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chamkhi]]></surname>
<given-names><![CDATA[Imane]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gürer]]></surname>
<given-names><![CDATA[Eda Sönmez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rad]]></surname>
<given-names><![CDATA[Javad Sharifi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Khulna University Pharmacy Discipline ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bangladesh</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Bangabandhu Sheikh Mujibur Rahman Science and Technology University Department of Pharmacy ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bangladesh</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,BioLuster Research Center Ltd. Bioinformatics and Drug Innovation Laboratory ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bangladesh</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Milan State University Department of Agricultural and Environmental Sciences ]]></institution>
<addr-line><![CDATA[Milan ]]></addr-line>
<country>Italy</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Mohammed V University in Rabat Faculty of Sciences Laboratory of Materials, Nanotechnology and Environment]]></institution>
<addr-line><![CDATA[Rabat ]]></addr-line>
<country>Morocco</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Mohammed V University in Rabat Scientific Institute Geo-Biodiversity and Natural Patrimony Laboratory]]></institution>
<addr-line><![CDATA[Rabat ]]></addr-line>
<country>Morocco</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Sivas Cumhuriyet University Faculty of Pharmacy Department of Pharmacognosy]]></institution>
<addr-line><![CDATA[Sivas ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Universidad del Azuay Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Cuenca ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<volume>31</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-40042024000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-40042024000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-40042024000200002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings.  Objective: To evaluate the current understanding of its toxicological effects on humans and animals, a literature and laboratory-based study was conducted.  Methods: A comprehensive search of published literature was conducted in various databases up until April 2020, using specific keywords. Additionally, toxic effects of RPZ-Na (0.025-0.4 mM) were evaluated on Allium cepa, Allium sativum and Cicer arietinum at different exposure times using CuSO4 as a reference standard.  Results: The literature review revealed that RPZ has a wide range of side effects including nausea, vomiting, diarrhea, headache, rhinitis, myalgia, pharyngitis, abdominal pain, dyspepsia, and eye disorders. Chronic exposure to RPZ has also been associated with significant biochemical and hematological alterations, as well as various toxicological effects such as hypergastrinemia, hyperplasia, atrophy of gastric glands, gastric anti-secretory effect, and hypochlorhydria. The laboratory analysis showed that RPZ-Na concentration-dependently inhibited root length of A. cepa and A. sativum, as well as shoot and root lengths of C. arietinum.  Conclusions: This study highlights the toxicological impacts of RPZ and its formulations on human and animals. Results suggest that RPZ-Na has a concentration-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: Se sabe que el rabeprazol (RPZ), un inhibidor de la bomba de protones ampliamente utilizado tiene efectos tóxicos en los seres humanos. Para evaluar los conocimientos actuales sobre sus efectos toxicológicos en humanos y animales, se realizó un estudio bibliográfico y de laboratorio. Para ello, se evaluó el efecto tóxico de RPZ-Na (0,025-0,4 mM) en Allium cepa, Allium sativum y Cicer arietinum a diferentes tiempos de exposición utilizando CuSO4 como estándar de referencia.  Resultados: La concentración de RPZ-Na inhibió de forma dependiente la longitud de las raíces de A. cepa y A. sativum, así como la longitud de los brotes y raíces de C. arietinum. RPZ-Na a 0,1 a 0,4 µg/mL y a 48 y 48 h de tiempo de exposición ejerció efectos más tóxicos sobre los sistemas de prueba.  Conclusiones: RPZ-Na ejerció un efecto tóxico dependiente de la concentración y del tiempo en A. cepa, A. sativum y C. arietinum. Por lo tanto, es importante tomar las precauciones adecuadas durante su uso a largo plazo.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Rabeprazol]]></kwd>
<kwd lng="es"><![CDATA[Allium cepa]]></kwd>
<kwd lng="es"><![CDATA[Allium sativum]]></kwd>
<kwd lng="es"><![CDATA[Cicer arietinum]]></kwd>
<kwd lng="es"><![CDATA[Herramientas de monitoreo de toxicidad]]></kwd>
<kwd lng="en"><![CDATA[Rabeprazole]]></kwd>
<kwd lng="en"><![CDATA[Allium cepa]]></kwd>
<kwd lng="en"><![CDATA[Allium sativum]]></kwd>
<kwd lng="en"><![CDATA[Cicer arietinum]]></kwd>
<kwd lng="en"><![CDATA[Toxicity monitoring tools]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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