<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-4004</journal-id>
<journal-title><![CDATA[Vitae]]></journal-title>
<abbrev-journal-title><![CDATA[Vitae]]></abbrev-journal-title>
<issn>0121-4004</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Química Farmacéutica, Universidad de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-40042025000100002</article-id>
<article-id pub-id-type="doi">10.17533/udea.vitae.v32n1a356558</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Phoradendron bathyoryctum Eichler relieves acute nociceptive pain stimulus and carrageenan-induced inflammation in mice]]></article-title>
<article-title xml:lang="es"><![CDATA[Phoradendron bathyoryctum Eichler alivia el estímulo de dolor nociceptivo y la inflamación aguda inducida por carragenina en ratones]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz Rivas]]></surname>
<given-names><![CDATA[Mariela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Heinichen]]></surname>
<given-names><![CDATA[Olga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arrúa]]></surname>
<given-names><![CDATA[Wilfrido]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Degen]]></surname>
<given-names><![CDATA[Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibarrola]]></surname>
<given-names><![CDATA[Derlis. A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hellión-Ibarrola]]></surname>
<given-names><![CDATA[María del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Farmacología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Botánica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>32</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-40042025000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-40042025000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-40042025000100002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  The genus Phoradendron belongs to the Santalaceae family and possesses several species with antitumor, cytotoxic, and immunomodulatory activity, where pain and inflammation are common symptoms. It is used in venereal and liver diseases in Paraguayan folk medicine. In addition, it claims to have tonic properties for the heart and central nervous system. Previous studies have shown that crude extract of Phoradendron bathyoryctum Eichler (Pb) has anxiolytic and antidepressant activity.  Objective:  This work aimed to determine the anti-nociceptive and anti-inflammatory activity of Pb using acute models in mice.  Methods:  the anti-nociceptive activity of Pb was evaluated using mechanical pressure (Randall-Selitto test), acetic acid (writhing test), and heat (hot plate test) noxious stimulus in mice. The anti-inflammatory activity was assessed through carrageenan-induced plantar edema in mice previously treated with Pb.  Results:  Presences of high polarity alkaloids, steroids/ free triterpenoids, leucoanthocyanidins, and tannins were detected in phytochemical studies. Oral doses of 30 (p&lt;0.01) and 300 (p&lt;0.001) mg/kg of Pb denoted a significant dose-dependent increase in pain threshold, using the Randall-Selitto and Writhing test (30; p&lt;0.05; and 300; p&lt;0.01. In addition, consistent with the above anti-nociceptive effect, an increase in the reaction latency time after oral administration of Pb at a dose of 300 mg/kg (p&lt;0.05) in the hot plate test was denoted. Finally, a significant reduction of edema (30 mg/kg; p&lt;0.01) induced by 1% carrageenan was evidenced, demonstrating a potential anti-inflammatory activity of Pb compared to the positive edema control. Interestingly, the anti-edematous activity of Pb showed a similar intensity response compared to the group treated with 10 mg/kg indomethacin (p&lt;0.01).  Conclusion:  This work revealed that the crude extract of Pb can increase pain threshold, be compatible with an analgesic effect, and reduce edema (anti-inflammatory) induced by Carrageenan in mice. Further pharmacological and chemical studies are being conducted to elucidate molecular mechanisms and components involved in the observed effects.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes:  El género Phoradendron pertenece a la familia Santalaceae y posee varias especies con actividad antitumoral, citotóxica e inmunomoduladora, donde el dolor y la inflamación son síntomas comunes. Se utiliza en enfermedades venéreas y hepáticas en la medicina popular paraguaya. Además, se le atribuyen propiedades tónicas para el corazón y el sistema nervioso central. Estudios anteriores han demostrado que el extracto crudo de Phoradendron bathyoryctum Eichler (Pb) tiene actividad ansiolítica y antidepresiva.  Objetivo:  Este trabajo tuvo como objetivo determinar la actividad anti nociceptiva y antiinflamatoria del Pb utilizando modelos agudos en ratones.  Métodos:  la actividad anti nociceptiva del Pb se evaluó mediante estímulos nocivos de presión mecánica (prueba de Randall-Selitto), ácido acético (prueba de contorsión) y calor (prueba de placa caliente) en ratones. Mientras que la actividad antiinflamatoria se evaluó mediante el edema plantar inducido por carragenina en ratones previamente tratados con Pb.  Resultados:  En los estudios fitoquímicos se detectaron presencia de alcaloides de alta polaridad, esteroides/triterpenoides libres, leucoantocianidinas y taninos. Dosis orales de 30 (p&lt;0,01) y 300 (p&lt;0,001) mg/kg de Pb denotaron un aumento significativo dosis-dependiente en el umbral del dolor, utilizando la prueba de Randall-Selitto y de contorsiones (30; p&lt;0,05; y 300; p&lt;0,01. Además, concordante con el efecto anti nociceptivo anterior, se denotó un aumento en el tiempo de latencia de reacción después de la administración oral de Pb a una dosis de 300 mg/kg (p&lt;0,05) en la prueba de la placa caliente. Finalmente, se evidenció una reducción significativa del edema de pata (30 mg/kg; p&lt;0,01) inducido por carragenina al 1%, demostrando una potencial actividad antiinflamatoria del Pb en comparación con el control positivo del edema. Curiosamente, la actividad antiedematosa del Pb mostró una respuesta de intensidad similar en comparación con el grupo tratado con 10 mg/kg de indometacina (p&lt;0,01).  Conclusión:  Este trabajo reveló que el extracto crudo de Pb posee la capacidad de aumentar el umbral del dolor, compatible con un efecto analgésico, y capacidad de reducir el edema (antiinflamatorio) inducido por carragenina en ratones. Se están realizando más estudios farmacológicos y químicos para dilucidar los mecanismos moleculares y los componentes implicados en los efectos observados.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Phoradendron bathyoryctum]]></kwd>
<kwd lng="es"><![CDATA[anti nociceptivo]]></kwd>
<kwd lng="es"><![CDATA[antiinflamatorio]]></kwd>
<kwd lng="es"><![CDATA[Randall-Selitto]]></kwd>
<kwd lng="es"><![CDATA[prueba de contorsión]]></kwd>
<kwd lng="es"><![CDATA[placa caliente]]></kwd>
<kwd lng="es"><![CDATA[pletismómetro]]></kwd>
<kwd lng="en"><![CDATA[Phoradendron bathyoryctum]]></kwd>
<kwd lng="en"><![CDATA[anti-nociceptive]]></kwd>
<kwd lng="en"><![CDATA[anti-inflammatory]]></kwd>
<kwd lng="en"><![CDATA[Randall-Selitto]]></kwd>
<kwd lng="en"><![CDATA[writhing test]]></kwd>
<kwd lng="en"><![CDATA[hot plate]]></kwd>
<kwd lng="en"><![CDATA[plethysmometer]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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