<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-5256</journal-id>
<journal-title><![CDATA[Revista Med]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Med]]></abbrev-journal-title>
<issn>0121-5256</issn>
<publisher>
<publisher-name><![CDATA[Universidad Militar Nueva Granada. Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-52562018000200060</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[SIGNO DE LESER-TRÉLAT, SIGNO PARANEOPLÁSICO EN CÁNCER DE MAMA METASTÁSICO: PRESENTACIÓN DE CASO]]></article-title>
<article-title xml:lang="en"><![CDATA[LESER-TRÉLAT SIGN: PARANEOPLASTIC SIGN IN METASTATIC BREAST CANCER, CASE PRESENTATION]]></article-title>
<article-title xml:lang="pt"><![CDATA[SINAL DE LESER-TRÉLAT: SINAL PARANEOPLÁSICO EM CÂNCER DE MAMA METASTÁTICO, APRESENTAÇÃO DE CASO]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[TIBADUIZA MOGOLLÓN]]></surname>
<given-names><![CDATA[YURIET ALEXANDRA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[MIRANDA-DIAZ]]></surname>
<given-names><![CDATA[AUDREY JOSÉ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[NAVAS TORREJANO]]></surname>
<given-names><![CDATA[DIANA STEFANIA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia  ]]></institution>
<addr-line><![CDATA[Tunja ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Industrial de Santander  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Cartagena  ]]></institution>
<addr-line><![CDATA[Bolívar ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>26</volume>
<numero>2</numero>
<fpage>60</fpage>
<lpage>64</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-52562018000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-52562018000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-52562018000200060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El signo de Leser-Trélat es una erupción súbita y de veloz crecimiento de cuantiosas queratosis seborreicas secundarias a una neoplasia interna. Estas pueden estar relacionadas con prurito y acantosis nigricans. Las neoplasias asociadas frecuentemente al signo de Leser-Trélat son los adenocarcinomas gástricos, de colon y mama, representado en menor cantidad por linfomas, carcinoma de células escamosas y malignidades hematológicas. Siendo el signo de Leser-Trélat una dermatosis paraneoplásica infrecuente, se presenta un caso de una paciente de 76 años con cáncer de mama avanzado asociado a este signo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The Leser-Trelat sign is a sudden and rapid growth eruption of large seborrheic keratoses secondary to an internal neoplasm. These may be related to pruritus and acanthosis nigricans. The neoplasms frequently associated with the Leser-Trélat sign are gastric, colon and breast adenocarcinomas, represented to a lesser extent by lymphomas, squamous cell carcinoma and hematological malignancies. As the Leser-Trélat sign is an uncommon paraneoplastic dermatosis, a case of a 76-year-old patient with advanced breast cancer associated with this sign is presented.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O sinal de Leser-Trélat é uma erupção súbita e de veloz crescimento de múltiplas ceratoses seborreicas secundárias a uma neoplasia interna. Estas podem estar relacionadas com prurido e acantose nigricans. As neoplasias associadas frequentemente ao sinal de Leser-Trélat são os adenocarcinomas gástricos, de colón e mama, representado em menor quantidade por linfomas, carcinoma de células escamosas e malignidades hematológicas. Sendo o sinal de Leser-Trélat uma dermatose paraneoplásica infrequente, apresenta-se um caso de uma paciente de 76 anos com câncer de mama avançado associado a esse sinal.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[erupción]]></kwd>
<kwd lng="es"><![CDATA[queratosis seborreica]]></kwd>
<kwd lng="es"><![CDATA[prurito]]></kwd>
<kwd lng="es"><![CDATA[acantosis nigricans]]></kwd>
<kwd lng="es"><![CDATA[adenocarcinoma, neoplasias de la mama]]></kwd>
<kwd lng="en"><![CDATA[eruption]]></kwd>
<kwd lng="en"><![CDATA[seborrheic keratosis]]></kwd>
<kwd lng="en"><![CDATA[pruritus]]></kwd>
<kwd lng="en"><![CDATA[acanthosis nigricans]]></kwd>
<kwd lng="en"><![CDATA[adenocarcinoma, breast neoplasms]]></kwd>
<kwd lng="pt"><![CDATA[erupção]]></kwd>
<kwd lng="pt"><![CDATA[ceratose seborreica]]></kwd>
<kwd lng="pt"><![CDATA[prurido]]></kwd>
<kwd lng="pt"><![CDATA[acantose nigricans]]></kwd>
<kwd lng="pt"><![CDATA[adenocarcinoma, neoplasias da mama]]></kwd>
</kwd-group>
</article-meta>
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