<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-5256</journal-id>
<journal-title><![CDATA[Revista Med]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Med]]></abbrev-journal-title>
<issn>0121-5256</issn>
<publisher>
<publisher-name><![CDATA[Universidad Militar Nueva Granada. Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-52562019000200085</article-id>
<article-id pub-id-type="doi">10.18359/rmed.3515</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sirenomelia dipus en embarazo gemelar de madre adolescente. Reporte de un caso y revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Sirenomelia dipus in Twin Pregnancy in an Adolescent Mother. Case Report and Literature Review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Sirenomelia dipus em gestação gemelar de mãe adolescente. Relato de um caso e revisão da literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Hoyos]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Niño]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Clínica San Rafael  ]]></institution>
<addr-line><![CDATA[Bogotá DC]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Clínica San Rafael  ]]></institution>
<addr-line><![CDATA[Bogotá DC]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad El Bosque  ]]></institution>
<addr-line><![CDATA[Bogotá DC]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<fpage>85</fpage>
<lpage>92</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-52562019000200085&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-52562019000200085&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-52562019000200085&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La sirenomelia, también conocida como síndrome de la sirena, es una malformación congénita grave, generalmente incompatible con la vida, poco frecuente y de etiología aun no establecida, aunque se sospechan causas heterogéneas, específicamente, de origen vascular, pero que finalmente no han sido totalmente dilucidadas. Reporta una incidencia de 1 por cada 24 000-67 000 nacidos, caracterizada por la fusión de los miembros inferiores y asociada alteraciones en diferentes órganos y sistemas, entre las cuales las malformaciones renales son las más frecuentes. En el presente artículo reportamos el caso de un recién nacido, producto de embarazo gemelar con uno de los fetos que cursa con sirenomelia, sin diagnóstico prenatal, en un hospital de cuarto nivel, en Bogotá, Colombia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Sirenomelia, also known as siren syndrome, is a rare serious congenital malformation, generally incompatible with life, whose etiology has not yet been established. Although heterogeneous causes are suspected, specifically of vascular origin, they have not been fully elucidated. It reports an incidence of 1 per 24,000-67,000 newborns and is characterized by the fusion of the lower limbs and associated alterations in various organs and systems, among which kidney malformations are the most frequent. This article reports the case of a newborn, product of twin pregnancy, who has sirenomelia without a prenatal diagnosis at a fourth-level hospital in Bogotá, Colombia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A sirenomelia, também conhecida como a "síndrome da sereia", é uma malformação congénita grave, geralmente incompatível com a vida, pouco frequente e de etiologia ainda não estabelecida, embora haja supostas causas heterogéneas, em específico, de origem vascular, mas que, finalmente, não são totalmente esclarecidas. Relatam uma incidência de 1 para cada 24 000-67 000 nascidos, caracterizada pela fusão dos membros inferiores e associada a alterações em diferentes órgãos e sistemas, entre as quais as malformações renais são as mais frequentes. Neste artigo, relatamos o caso de um recém-nascido, produto de uma gestação gemelar com um dos fetos que cursa com sirenomelia, sem diagnóstico pré-natal, em um hospital quaternário de Bogotá, Colômbia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sirenomelia tipo I]]></kwd>
<kwd lng="es"><![CDATA[dipus]]></kwd>
<kwd lng="es"><![CDATA[malformación congénita]]></kwd>
<kwd lng="en"><![CDATA[Type I sirenomelia]]></kwd>
<kwd lng="en"><![CDATA[dipus]]></kwd>
<kwd lng="en"><![CDATA[congenital malformation]]></kwd>
<kwd lng="pt"><![CDATA[sirenomelia tipo I]]></kwd>
<kwd lng="pt"><![CDATA[dipus]]></kwd>
<kwd lng="pt"><![CDATA[malformação congénita]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaygusuz]]></surname>
<given-names><![CDATA[EI]]></given-names>
</name>
<name>
<surname><![CDATA[Eken]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Sivrikoz]]></surname>
<given-names><![CDATA[ON]]></given-names>
</name>
<name>
<surname><![CDATA[Cetiner]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia: A review of embryogenic theories and discussion of the differences from caudal regression syndrome]]></article-title>
<source><![CDATA[The Journal of Maternal-Fetal &amp; Neonatal Medicine]]></source>
<year>2016</year>
<volume>29</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>949-53</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castilla]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[Orioli]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ECLAMC: the Latin-American collaborative study of congenital malformations]]></article-title>
<source><![CDATA[Community Genet]]></source>
<year>2004</year>
<volume>7</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>76-94</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vijayaraghavan]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
<name>
<surname><![CDATA[Amudha]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High-resolution sonographic diagnosis of sirenomelia]]></article-title>
<source><![CDATA[J Ultrasound Med]]></source>
<year>2006</year>
<volume>25</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>555-7</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Keirsbilck]]></surname>
<given-names><![CDATA[JV]]></given-names>
</name>
<name>
<surname><![CDATA[Cannie]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Robrechts]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ravel]]></surname>
<given-names><![CDATA[T de]]></given-names>
</name>
<name>
<surname><![CDATA[Dymarkowski]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[First trimester diagnosis of sirenomelia]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Bosch]]></surname>
<given-names><![CDATA[TV den]]></given-names>
</name>
</person-group>
<source><![CDATA[Prenatal Diagnosis]]></source>
<year>2006</year>
<volume>26</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>684-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Orioli]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Amar]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Arteaga]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia: An epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Vazquez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bakker]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Bianca]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Botto]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
</person-group>
<source><![CDATA[American Journal of Medical Genetics Part C: Seminars in Medical Genetics]]></source>
<year>2011</year>
<volume>157</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>358-73</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thottungal]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Charles]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Dickinson]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Bower]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caudal dysgenesis and sirenomelia-single centre experience suggests common pathogenic basis]]></article-title>
<source><![CDATA[American Journal of Medical Genetics Part A]]></source>
<year>2010</year>
<volume>152A</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2578-87</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lhuaire]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jestin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Boulagnon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Loock]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia: A new type, Showing VACTERL Association with thomas syndrome and a review of literature]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Doco]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Fenzy]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gaillard]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Birth Defects Research Part A: Clinical and Molecular Teratology]]></source>
<year>2013</year>
<volume>97</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>123-32</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Adachi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Numata]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nakada]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Yanagita]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nakagata]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: A new mouse model of sirenomelia]]></article-title>
<source><![CDATA[PLOS ONE]]></source>
<year>2012</year>
<volume>7</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dunn]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Gluecksohn-Schoenheimer]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Repeated Mutations in One Area of a Mouse Chromosome]]></article-title>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>1950</year>
<volume>36</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>233-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zakin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Reversade]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kuroda]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Lyons]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[De Robertis]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm]]></article-title>
<source><![CDATA[Development]]></source>
<year>2005</year>
<volume>132</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2489-99</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valenzano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Paoletti]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rossi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Farinini]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Garlaschi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Fulcheri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia. Pathological features, antenatal ultrasonographic clues, and a review of current embryogenic theories]]></article-title>
<source><![CDATA[Hum Reprod Update]]></source>
<year>1999</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>82-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sikandar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Munim]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia, the mermaid syndrome: case report and a brief review of literature]]></article-title>
<source><![CDATA[J Pak Med Assoc]]></source>
<year>2009</year>
<volume>59</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>721-3</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Förster]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Die Missbildungen des Menschen systematisch dargestellt; Nebst einem Atlas von 26 Tafeln mit Erláuterungen]]></source>
<year>1861</year>
<edition>1a</edition>
<page-range>344</page-range><publisher-loc><![CDATA[Jena ]]></publisher-loc>
<publisher-name><![CDATA[Friedrich Mauke]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stocker]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Heifetz]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia. A morphological study of 33 cases and review of the literature]]></article-title>
<source><![CDATA[Perspect Pediatr Pathol]]></source>
<year>1987</year>
<volume>10</volume>
<page-range>7-50</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kállén]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Castilla]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[Lancaster]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Mutchinick]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Knudsen]]></surname>
<given-names><![CDATA[LB]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Frías]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The cyclops and the mermaid: an epidemiological study of two types of rare malformation]]></article-title>
<source><![CDATA[J Med Genet]]></source>
<year>1992</year>
<volume>29</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>30-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nori]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Prasad]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Reddy]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Cheguri]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fetal MR imaging analysis of sirenomelia with clinico radiographic correlation: A case report]]></article-title>
<source><![CDATA[J Clin Diagn Res]]></source>
<year>2016</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>TD08-10</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murphy]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fraser]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Blair]]></surname>
<given-names><![CDATA[GK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sirenomelia: case of the surviving mermaid]]></article-title>
<source><![CDATA[J Pediatr Surg]]></source>
<year>1992</year>
<volume>27</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1265-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
