<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-5256</journal-id>
<journal-title><![CDATA[Revista Med]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Med]]></abbrev-journal-title>
<issn>0121-5256</issn>
<publisher>
<publisher-name><![CDATA[Universidad Militar Nueva Granada. Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-52562021000200093</article-id>
<article-id pub-id-type="doi">10.18359/rmed.5706</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Genética de las fisuras labiopalatinas: una visión general de los factores de riesgo genéticos y ambientales]]></article-title>
<article-title xml:lang="en"><![CDATA[Genetics of Cleft Lip and Palate: An Overview of Genetic and Environmental Risk Factors]]></article-title>
<article-title xml:lang="pt"><![CDATA[Genética de fissura labial e palatina: urna visão geral de atores de risco genético e ambiental]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pusapaz Pusapaz]]></surname>
<given-names><![CDATA[Daniela Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arturo Terranova]]></surname>
<given-names><![CDATA[María Camila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Terranova]]></surname>
<given-names><![CDATA[Daniela Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidad Central del Valle del Cauca  ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>29</volume>
<numero>2</numero>
<fpage>93</fpage>
<lpage>105</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-52562021000200093&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-52562021000200093&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-52562021000200093&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: las fisuras labiopalatinas son malformaciones congénitas del sistema estomatognático, se presentan por alteración de las estructuras anatómicas del cráneo, la cara y la cavidad bucal, debido a una falla en la fusión de tejidos en la embriogénesis; las malformaciones pueden ser del labio, el paladar duro, el velo del paladar, la mucosa palatina y en algunos casos de la cavidad nasal; por lo demás, afectan las estructuras que participan en las funciones del lenguaje, el habla y la audición. Objetivo: Identificar los factores genéticos y ambientales asociados a las fisuras labiopalatinas.  Metodología:  la revisión bibliográfica se realizó en bases de datos académicas PubMed, LILACS, OVID-MEDLINE usando lenguaje normalizado con términos DECS-LILACS: exposición a riesgos ambientales, fisura del paladar, labio leporino, genética, medicina de precisión y síndrome; se aplicaron filtros de búsqueda propios de las bases de datos, tipos de textos científicos e información relevante para la investigación. De acuerdo con los resultados de la búsqueda bibliográfica se encontró que la etiología de las fisuras es multifactorial y se asocia a factores genéticos y ambientales. La identificación de diversos genes relacionados con estas malformaciones ha permitido reconocer oportunamente cuándo una fisura es sindrómica o no sindrómica, lo que lleva a entender la interacción gen por gen, a identificar variantes funcionales y a comprender su importancia etiológica.  Conclusiones:  el estudio y el conocimiento acerca de los mecanismos moleculares que se encuentran involucrados en la formación de las fisuras labiopalatinas ha tomado fuerza gracias al entendimiento del genoma humano y al desarrollo de herramientas modernas de biología molecular que permiten identificar gran cantidad de datos de secuencia, haciendo que los genes candidatos aumenten constantemente. Esto permitirá un manejo oportuno de la enfermedad, la identificación del riesgo de ocurrencia y un tratamiento especializado mediante la medicina de precisión.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: cleft lip and palate are congenital malformations of the stomatognathic system; they occur due to an alteration of the anatomical structures of the skull, face and oral cavity, due to a failure in the fusion of tissues in embryogenesis; malformations can be of the lip, hard palate, soft palate, palatal mucosa, and in some cases of the nasal cavity; moreover, they affect the structures involved in the functions of language, speech, and hearing. Objective: To identify the genetic and environmental factors associated with cleft lip and palate.  Methodology:  the bibliographic review was carried out in PubMed, LILACS, OVID-MEDLINE academic databases using standardized language with decs-lilacs terms: exposure to environmental risks, cleft palate, cleft lip, genetics, precision medicine and syndrome; Search filters of the databases, types of scientific texts and information relevant to the research were applied. According to the results of the bibliographic search, it was found that the etiology of the fissures is multifactorial and is associated with genetic and environmental factors. The identification of various genes related to these malformations has made it possible to timely recognize when a cleft is syndromic or non-syndromic, which leads to understanding gene-by-gene interaction, identifying functional variants and understanding their etiological importance.  Conclusions:  the study and knowledge regarding the molecular mechanisms that are involved in the formation of cleft lip and palate has gained strength thanks to the understanding of the human genome and the development of modern molecular biology tools that allow the identification of large amounts of sequence data, causing the candidate genes to increase constantly.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: as fissuras labiopalatais são malformações congénitas do sistema estomatognático, ocorrem por alterado das estruturas anatómicas do crânio, face e cavidade oral, por falha na fusão dos tecidos na embriogênese; as malformações podem ser do lábio, palato duro, palato mole, mucosa palatina e, em alguns casos, da cavidade nasal; caso contrário, afetam as estruturas envolvidas nas funções da linguagem, fala e audição. Objetivo: Identificar os fatores genéticos e ambientais associados á fissura labiopalatal.  Metodologia: a revisão bibliográfica foi realizada nas bases de dados académicas PubMed, LILACS, OVID-MEDLINE utilizando linguagem normalizada com termos DECS-LILACS: exposição a riscos ambientais, fenda palatina, lábio leporino, genética, medicina de precisão e síndrome; foram aplicados filtros de busca das bases de dados, tipos de textos científicos e informados relevantes para a pesquisa. Segundo os resultados a partir da pesquisa bibliográfica, foi constatado que a etiologia das fissuras é multifatorial e está associada a fatores genéticos e ambientais. A identificado de vários genes relacionados a essas malformações permitiu reconhecer em curto tempo quando urna fissura é sindrómica ou não sindrômica, o que leva ao entendimento da interação gene a gene, identificado de variantes funcionais e compreensão de sua importância etiológica.  Conclusóes: o estudo e conhecimento sobre os mecanismos moleculares encontrados envolvidos na formação da fissura labiopalatal ganhou força graças á compreensão do genoma humano e o desenvolvimento de ferramentas modernas de biologia molecular que permitem a identificado de grandes quantidades de dados de sequênces, fazendo com que os genes candidatos aumentem constantemente. Isso permitirá a gestão atempada da doença, identificado do risco de ocorrência e tratamento especializado através da medicina de precisão.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[exposición a riesgos ambientales]]></kwd>
<kwd lng="es"><![CDATA[fisura del paladar]]></kwd>
<kwd lng="es"><![CDATA[labio leporino]]></kwd>
<kwd lng="es"><![CDATA[genética]]></kwd>
<kwd lng="es"><![CDATA[medicina de precisión]]></kwd>
<kwd lng="es"><![CDATA[síndrome (DeCs)]]></kwd>
<kwd lng="en"><![CDATA[exposure to environmental risks]]></kwd>
<kwd lng="en"><![CDATA[cleft palate]]></kwd>
<kwd lng="en"><![CDATA[harelip]]></kwd>
<kwd lng="en"><![CDATA[genetics]]></kwd>
<kwd lng="en"><![CDATA[precision medicine]]></kwd>
<kwd lng="en"><![CDATA[syndrome (DeCs)]]></kwd>
<kwd lng="pt"><![CDATA[exposição a riscos ambientais]]></kwd>
<kwd lng="pt"><![CDATA[fenda palatina]]></kwd>
<kwd lng="pt"><![CDATA[lábio leporino]]></kwd>
<kwd lng="pt"><![CDATA[genética]]></kwd>
<kwd lng="pt"><![CDATA[medicina de precisão]]></kwd>
<kwd lng="pt"><![CDATA[síndrome (DeCs)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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