<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-7488</journal-id>
<journal-title><![CDATA[Ciencia en Desarrollo]]></journal-title>
<abbrev-journal-title><![CDATA[Ciencia en Desarrollo]]></abbrev-journal-title>
<issn>0121-7488</issn>
<publisher>
<publisher-name><![CDATA[Universidad Pedagógica y Tecnológica de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-74882020000100119</article-id>
<article-id pub-id-type="doi">10.19053/01217488.v11.n1.2020.9869</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad fosfolipasa, hemolítica y bactericida preliminar del veneno de la serpiente de cascabel del Tolima]]></article-title>
<article-title xml:lang="en"><![CDATA[Preliminary phospholipase, hemolytic and bactericidal activity of the venom of the snake of cascabel del Tolima]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solano Godoy]]></surname>
<given-names><![CDATA[Jennifer Alexandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Molano Cardona]]></surname>
<given-names><![CDATA[Emerson David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernal Bautista]]></surname>
<given-names><![CDATA[Manuel Hernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murillo Arango]]></surname>
<given-names><![CDATA[Walter]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Tolima  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Tolima Facultad de Ciencias ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Tolima Facultad de Ciencias ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>11</volume>
<numero>1</numero>
<fpage>119</fpage>
<lpage>127</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-74882020000100119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-74882020000100119&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-74882020000100119&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En el departamento del Tolima no hay estudios que permitan precisar con certeza la magnitud del accidente ofídico causado por Crotalus durissus, existiendo la necesidad de generar información sobre el perfil proteico, como forma de aproximación a la compresión de algunas actividades biológicas relacionadas con la toxicidad del veneno, así como su potencial biotecnológico. En este trabajo se analizó el perfil electroforético por SDS-PAGE del veneno crudo extraído de individuos colectados en el municipio de Natagaima (Tolima) y la asociación con actividades fosfolipasa, hemolítica directa e indirecta y bactericida sobre Escherichia coli, Staphylococcus aureus y Pseudomona aeuroginosa. El veneno crudo presentó bandas de peso molecular 26.6 kDa., 17, 14.2, 6.5, 3.5 y 1.06 kDa., correspondientes con otros reportes previos del veneno para la especie. Se presentaron niveles considerables de actividades hemolítica (200 &#956;g) y fosfolipasa (1.25 UA/mg. ± 0.88) dependientes de Calcio, y el efecto bactericida del veneno crudo fue diferencial sobre los microorganismos evaluados, presentando actividad moderada sobre Escherichia coli. Los resultados constituyen datos valiosos que confieren un acercamiento hacia el conocimiento del potencial tóxico del veneno de Crotalus durissus (cascabel) de la zona de Natagaima-Tolima, así como de la capacidad bactericida y posibles aplicaciones futuras en campos de investigación relacionados con la búsqueda de nuevos agentes antimicrobianos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In the department of Tolima, there are no studies that allow us to determine with certainty the magnitude of the ophidian accident caused by Crotalus durissus, and there is a need to generate information on the protein profile, as a way of approaching the compression of some biological activities related to the toxicity of the venom, as well as its biotechnological potential. In this work, the SDS-PAGE electrophoretic profile of the crude venom extracted from individuals collected in the municipality of Natagaima (Tolima) and the association with phospholipase, direct and indirect hemolytic and bactericidal activities on Escherichia coli, Staphylococcus aureus and Pseudomonas aeuroginosa were analysed. The crude venom presented bands of molecular weight 26.6 kDa., 17, 14.2, 6.5, 3.5 and 1.06 kDa., corresponding to other previous reports of the venom for the specie. Considerable levels of calcium-dependent-hemolytic (200 &#956;g) and phospholipase (1.25 AU/mg. ± 0.88) activities were presented, and the bactericidal effect of the crude venom was differential on the microorganisms evaluated, showing moderate activity on Escherichia coli. The results constitute valuable data that confer an approach towards the knowledge of the toxic potential of the venom of Crotalus durissus (rattlesnake) from the Natagaima-Tolima area, as well as the bactericidal capacity and possible future applications in research fields related to the search for new antimicrobial agents.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Actividad bactericida, Cascabel, Crotalus durissus]]></kwd>
<kwd lng="es"><![CDATA[Fosfolipasas, Hemolisis, Toxinologia, Veneno]]></kwd>
<kwd lng="en"><![CDATA[Crotalus durissus]]></kwd>
<kwd lng="en"><![CDATA[Bactericidal activity]]></kwd>
<kwd lng="en"><![CDATA[Hemolysis]]></kwd>
<kwd lng="en"><![CDATA[Phospholipases]]></kwd>
<kwd lng="en"><![CDATA[Rattlesnake]]></kwd>
<kwd lng="en"><![CDATA[Toxinology]]></kwd>
<kwd lng="en"><![CDATA[Venom]]></kwd>
</kwd-group>
</article-meta>
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