<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-7488</journal-id>
<journal-title><![CDATA[Ciencia en Desarrollo]]></journal-title>
<abbrev-journal-title><![CDATA[Ciencia en Desarrollo]]></abbrev-journal-title>
<issn>0121-7488</issn>
<publisher>
<publisher-name><![CDATA[Universidad Pedagógica y Tecnológica de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-74882022000200131</article-id>
<article-id pub-id-type="doi">10.19053/01217488.v13.n2.2022.14087</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio de nuevos complejos metálicos derivados de un ligando flexible polidentado para aplicaciones biológicas y biomédicas]]></article-title>
<article-title xml:lang="en"><![CDATA[Study of Novel Metal Complexes Derived From a Flexible Polydentate Ligand for Biological and Biomedical Applications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Londoño-Mosquera]]></surname>
<given-names><![CDATA[Juan-David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Polo-Cerón]]></surname>
<given-names><![CDATA[Dorian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>13</volume>
<numero>2</numero>
<fpage>131</fpage>
<lpage>157</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-74882022000200131&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-74882022000200131&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-74882022000200131&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El presente estudio muestra la obtención de cuatro nuevos complejos lantánidos con iones Gd(III) (1), Eu(III) (2), Dy(III) (3) y Yb(III) (4), con dos ligandos polidentados F y L para evaluar su potencial aplicación en el contraste de imágenes para microscopía de fluorescencia (MF), resonancia magnética de imágenes (RMI) y como agentes antibacterianos. Se propone que los complejos poseen una estructura molecular en donde los ligandos quelan al centro metálico a través de los grupos -OH, -N- y -COO-, exhibiendo un aparente número de coordinación de 7. La relajatividad molar r1 muestra que los cuatro complejos son capaces de acelerar el tiempo de relajación longitudinal T1 del agua, obteniéndose un r1 de 6.45 mmol_1&#903;L_1&#903;s_1 para el compuesto 1, el cual fue mayor que el valor 2.25 mmol_1&#903;L_1&#903;s_1 para el Dotarem® usado como medicamento de referencia en RMI. Los rendimientos cuánticos en referencia a la fluoresceína fueron menores al 1 %, exhibiendo baja eficiencia en los procesos de emisión de radiación visible. Para todos los complejos se obtuvieron constantes de estabilidad aparente (- log[k  ap ]) entre 21-18, siendo incluso, algunos, mejores que algunos agentes de contraste. El complejo 2 logró inhibir el crecimiento de las cepas bacterianas Gram-positivas y Gram-negativas evaluadas con concentraciones mínimas inhibitorias (CMIs) de hasta 250 mg&#903;L-1, en general los altos CIMs sugirieron que los complejos obtenidos podrían tener una potencial aplicación en contraste celular procariota por fluorescencia. Finalmente, se confirmó que los complejos obtenidos logran unirse a las hebras del ADN a través de un posible mecanismo de intercalación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This work shows the synthesis of four new lanthanide complexes of Gd(III) (1), Eu(III) (2), Dy(III) (3) and Yb(III) (4) ions, using two polydentate ligands F and L in order to evaluate their potential application on the contrast-imaging by fluorescence microscopy (MF), nuclear magnetic resonance (RMI) and as antibacterial agents. We propose a structure where both ligands are bound to the metal centre through -OH, -N- and -COO- groups, exhibiting an apparent coordination number of 7. Moreover, r1 molar relaxivities obtained demonstrates that all the complexes had the capability to accelerate longitudinal relaxation times (T1) of water, with a r1 value of 6.45 mmol-1&#903;L-1&#903;s-1 for compound 1, which was higher than r1 of 2.25 mmol-1&#903;L-1&#903;s-1 corresponding to commercial drug Dotarem® employed for RMI. Furthermore, all quantum yields of fluorescence, in reference to fluorescein, where lower than 1 %, showing a poor performance in emission processes of visible radiation. Stability constants determined as (- log[kap]) were between 21 and 18, being even better than some contrast agents. Compound 2 managed to inhibit the growth of Gram-positive and Gram-negative bacterial strains evaluated with minimum inhibitory concentrations (MICs) of up to 250 mg&#903;L-1, in general the high MICs suggested that the complexes obtained could have a potential application in prokaryotic cell fluorescence contrast. Finally, DNA binding experiments showed that all complexes had the capability to bind DNA strands by a possible intercalation mechanism.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ligando polidentado]]></kwd>
<kwd lng="es"><![CDATA[Iones lantánidos]]></kwd>
<kwd lng="es"><![CDATA[Agente de contraste]]></kwd>
<kwd lng="es"><![CDATA[Resonancia magnética nuclear]]></kwd>
<kwd lng="es"><![CDATA[Microscopía de fluorescencia]]></kwd>
<kwd lng="en"><![CDATA[Polydentate ligand]]></kwd>
<kwd lng="en"><![CDATA[Lanthanide ions]]></kwd>
<kwd lng="en"><![CDATA[Contrast agent]]></kwd>
<kwd lng="en"><![CDATA[Nuclear magnetic resonance]]></kwd>
<kwd lng="en"><![CDATA[Fluorescent microscopy]]></kwd>
</kwd-group>
</article-meta>
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