<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-8123</journal-id>
<journal-title><![CDATA[Revista Colombiana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Reumatol.]]></abbrev-journal-title>
<issn>0121-8123</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-81232018000400257</article-id>
<article-id pub-id-type="doi">10.1016/j.rcreu.2018.09.003</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Sublingual microcirculatory alterations in patients with stable systemic sclerosis]]></article-title>
<article-title xml:lang="es"><![CDATA[Alteraciones microcirculatorias sublinguales en pacientes con esclerosis sistémica estable]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hormaza]]></surname>
<given-names><![CDATA[Andrés-Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre-Valencia]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiñonez]]></surname>
<given-names><![CDATA[Edgardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suso]]></surname>
<given-names><![CDATA[Juan-Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Posso-Osorioa,]]></surname>
<given-names><![CDATA[Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Echeverri]]></surname>
<given-names><![CDATA[Andrés F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cañas]]></surname>
<given-names><![CDATA[Carlos A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tobón]]></surname>
<given-names><![CDATA[Gabriel J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ospina-Tascón]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bonilla-Abadía]]></surname>
<given-names><![CDATA[Fabio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Valle del Lili Rheumatology Unit ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Valle del Lili Intensive Care Unit ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Valle del Lili Clinical Investigation Institute ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Icesi Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Fundación Valle del Lili Laboratory of Immunology ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>25</volume>
<numero>4</numero>
<fpage>257</fpage>
<lpage>260</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-81232018000400257&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-81232018000400257&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-81232018000400257&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis, inflammation, and microcirculatory alterations.  Objective:  To evaluate abnormalities in the sublingual microcirculation of SSc patients and to establish any differences compared to healthy controls.  Methods:  The sublingual microcirculation was determined using a Sidestream dark-field (SDF) imaging device (MicroScan; MicroVision Medical, Amsterdam, the Netherlands) in patients with SSc and controls.  Results:  Twelve patients with SSc (75% with diffuse cutaneous SSc) were evaluated (mean age: 52.08 ± 2.08 years). A group of 20 volunteers was used as the control. Significantly lower total capillary density (TCD) (9.2 [8.5-9.7] vs. 10.9 [9.8-12.5]) and functional capillary density (FCD) (7.0 [6.8-7.5] vs. 8.6 [7.5-9.8]) were observed in SSc patients than in healthy controls.  Conclusions:  SSc is related to significantly lower capillary density in the sublingual microcirculation, and the SDF imaging technique could be an alternative to nailfold video-capillaroscopy for diagnosing and following-up patients with SSc.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La esclerosis sistémica (SSc) es una enfermedad autoimmune sistémica caracterizada por fibrosis, inflamación y alteraciones en la microcirculación.  Objetivo:  Evaluar anormalidades en la microcirculación sublingual de pacientes con diagnóstico de esclerosis sistémica y establecer diferencias en comparación con controles sanos.  Métodos:  Exploramos la microcirculación sublingual utilizando un dispositivo de imágenes de campo oscuro Sidestream (SDF) (Micro Scan, MicroVision Medical, Amsterdam, Holanda) en pacientes con SSc y controles.  Resultados:  Se evaluaron 12 pacientes con SSc estable (75% con cutánea difusa) (edad media: 52.08 ± 2.08). Un grupo de 20 voluntarios se utilizó como control. Se observó una disminución significativa en la densidad vascular total (TCD) (9.2 [8.5-9.7] vs. 10.9 [9.8-12.5]) y densidad capilar funcional (FCD) (7.0 [6.8-7.5] vs. 8.6 [7.5-9.8]) observado en pacientes con esclerosis sistémica en comparación con controles sanos.  Conclusiones:  La SSc se relaciona con la disminución significativa de la densidad capilar en la microcirculación sublingual, esta técnica podría ser una alternativa en pacientes críticos con esclerosis sistémica o utilizarse para seguimiento durante la hospitalización.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Scleroderma]]></kwd>
<kwd lng="en"><![CDATA[Systemic Scleroderma]]></kwd>
<kwd lng="en"><![CDATA[Diffuse]]></kwd>
<kwd lng="en"><![CDATA[Microcirculation]]></kwd>
<kwd lng="en"><![CDATA[Capillaroscopy]]></kwd>
<kwd lng="es"><![CDATA[Escleroderma]]></kwd>
<kwd lng="es"><![CDATA[Esclerosis sistémica]]></kwd>
<kwd lng="es"><![CDATA[Difuso]]></kwd>
<kwd lng="es"><![CDATA[Microcirculación]]></kwd>
<kwd lng="es"><![CDATA[Capilaroscopia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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