<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-8123</journal-id>
<journal-title><![CDATA[Revista Colombiana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Reumatol.]]></abbrev-journal-title>
<issn>0121-8123</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-81232021000200118</article-id>
<article-id pub-id-type="doi">10.1016/j.rcreu.2020.08.007</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Therapeutic effects of Durian wood bark extract on a rat model of rheumatoid arthritis]]></article-title>
<article-title xml:lang="es"><![CDATA[Los efectos terapéuticos del extracto de corteza de madera durián en un modelo de rata de artritis reumatoide]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ulhaq]]></surname>
<given-names><![CDATA[Zulvikar Syambani]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hendyatama]]></surname>
<given-names><![CDATA[Tenta Hartian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alluza]]></surname>
<given-names><![CDATA[Hamid HunaifDhofi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aulanni&#8217;am]]></surname>
<given-names><![CDATA[Aulanni&#8217;am]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Maulana Malik Ibrahim State Islamic University of Malang Faculty of Medicine and Health Sciences Department of Biochemistry]]></institution>
<addr-line><![CDATA[Batu East Java]]></addr-line>
<country>Indonesia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Airlangga University Faculty of Medicine Department of Internal Medicine]]></institution>
<addr-line><![CDATA[Surabaya East Java]]></addr-line>
<country>Indonesia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Brawijaya University Faculty of Medicine Department of Urology]]></institution>
<addr-line><![CDATA[Malang East Java]]></addr-line>
<country>Indonesia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Brawijaya University Faculty of Science Department of Biochemistry]]></institution>
<addr-line><![CDATA[Malang East Java]]></addr-line>
<country>Indonesia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<numero>2</numero>
<fpage>118</fpage>
<lpage>123</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-81232021000200118&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-81232021000200118&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-81232021000200118&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Rheumatoid arthritis (RA) is a common immune-mediated inflammatory disease characterized by increased inflammation of synovial joint, and often associated with disability. Although several studies have demonstrated the medicinal properties of durian, little is known about the role of durian wood bark for medicinal purposes. Thus, this study investigated the anti-arthritic activity of durian wood bark extract in a rat model of rheumatoid arthritis.  Methods: The rats were divided into five groups, including control, RA model, and RA model treated with durian wood bark extract (20, 30, and 40 mg/kg/day for 14 days). The effects of treatment were evaluated by clinical, as well as histological changes in the ankle joints, and the expression level of inducible nitric oxide synthase (iNOS).   Results: A complete Freund's adjuvant (CFA)-induced RA model in rats was successfully, characterized by the swelling of hind limbs, histopathological changes in ankle joints, and the upregulation of iNOS expression. The administration of durian wood bark extract at a dose of 40 mg/kg attenuated all parameters analyzed in CFA-induced RA model in rats.  Conclusion: Amelioration of hind limb swelling, histopathological changes, and iNOS expression in the RA model indicates that durian wood bark extract can be considered as a new treatment alternative that reduces joint symptoms, as well as a future area of research in humans.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Antecedentes: La artritis reumatoide (AR) es una enfermedad inflamatoria común mediada por el sistema inmunológico que se caracteriza por una mayor inflamación de la articulación sinovial, y a menudo se asocia con discapacidad. Aunque en varios estudios se han demostrado las propiedades medicinales del durián, se conoce poco sobre el papel de la corteza de madera de durián con fines médicos. Así pues, en este estudio se investigó la actividad antiartrítica del extracto de corteza de madera de durián en un modelo de AR en ratas.  Métodos: Las ratas se dividieron en 5 grupos, incluyendo el control, el modelo de AR y el modelo de AR tratado con extracto de corteza de madera durián (20, 30 y 40mg/kg/día durante 14 días). Los efectos del tratamiento se evaluaron mediante cambios clínicos e histológicos en las articulaciones de los tobillos y el nivel de expresión de la sintasa de óxido nítrico inducible (iNOS).   Resultados:  Desarrollamos con éxito un modelo completo de AR inducida por adyuvantes de Freund (CFA) en ratas, caracterizado por la hinchazón de las extremidades posteriores, los cambios histopatológicos de las articulaciones del tobillo y el aumento de la expresión de la iNOS. La administración de extracto de corteza de madera de durián a una dosis de 40 mg/kg atenuó todos los parámetros analizados en el modelo de AR inducida por CFA en ratas.  Conclusión: La mejora de la hinchazón de las extremidades traseras, los cambios histopatológicos y la expresión de iNOS en el modelo de AR indican que el extracto de corteza de madera dura puede considerarse una nueva alternativa de tratamiento para reducir los síntomas de las articulaciones, con un futuro campo de investigación en los seres humanos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Rheumatoid arthritis]]></kwd>
<kwd lng="en"><![CDATA[Durian wood bark extract]]></kwd>
<kwd lng="en"><![CDATA[CFA-induced RA model]]></kwd>
<kwd lng="es"><![CDATA[Artritis reumatoide]]></kwd>
<kwd lng="es"><![CDATA[Extracto de corteza de madera de durián]]></kwd>
<kwd lng="es"><![CDATA[Modelo de AR inducida por CFA]]></kwd>
</kwd-group>
</article-meta>
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