<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-8123</journal-id>
<journal-title><![CDATA[Revista Colombiana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Reumatol.]]></abbrev-journal-title>
<issn>0121-8123</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-81232024000400480</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Central tolerance in T cells, what's new?]]></article-title>
<article-title xml:lang="es"><![CDATA[Tolerancia central de las células T, ¿qué hay de nuevo?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Imbachí-Salamanca]]></surname>
<given-names><![CDATA[Alex]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vásquez]]></surname>
<given-names><![CDATA[Gloria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia Rheumatology Group Faculty of Medicine]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia Cellular Immunology and Immunogenetics Group Faculty of Medicine]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>31</volume>
<numero>4</numero>
<fpage>480</fpage>
<lpage>488</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-81232024000400480&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-81232024000400480&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-81232024000400480&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Random somatic recombination of T cell receptors facilitates the variability of response to foreign antigens. Then, central tolerance occurs, a mechanism designed to avoid exit of autoreactive T cells from the thymus. However, failures in this process can induce the appearance of autoimmunity.  Materials and methods: This narrative review was conducted through a literature search focused on describing relevant and recent concepts of central tolerance of T cells.  Results: Multiple cell groups are part of the thymic microenvironment, among them, thymic epithelial cells are responsible for directing development of thymocytes, especially medullary thymic epithelial cells that direct the negative selection process.  Conclusions: Factors that affect thymocytes, the thymic microenvironment, or interaction between them, can lead to development of immunodeficiencies and/or autoimmunity.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La recombinación somática aleatoria de los receptores de células T facilita la variabilidad de respuesta frente a antígenos exógenos. Posteriormente a ella se da la tole rancia central, mecanismo dirigido a evitarla salida del timo de células T autorreactivas. Sin embargo, fallos en este proceso pueden inducir la aparición de autoinmunidad.  Materiales y métodos:  Esta revisión narrativa se llevó a cabo mediante una búsqueda de la literatura enfocada en describir conceptos relevantes y recientes de la tolerancia central de las células T.  Resultados:  Múltiples grupos celulares hacen parte del microambiente tímico, entre los cua les las células epiteliales tímicas son las encargadas de dirigir el desarrollo de los timocitos, específicamente las células epiteliales tímicas medulares que dirigen el proceso de selección negativa.  Conclusiones:  Los factores que afectan a los timocitos, el microambiente tímico o la interac ción entre estos pueden llevar al desarrollo de inmunodeficiencias o autoinmunidad.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Central tolerance]]></kwd>
<kwd lng="en"><![CDATA[Autoimmunity]]></kwd>
<kwd lng="en"><![CDATA[T-lymphocytes]]></kwd>
<kwd lng="en"><![CDATA[AIRE deficiency]]></kwd>
<kwd lng="en"><![CDATA[Human FEZF2 protein]]></kwd>
<kwd lng="es"><![CDATA[Tolerancia central]]></kwd>
<kwd lng="es"><![CDATA[Autoinmunidad]]></kwd>
<kwd lng="es"><![CDATA[Linfocitos T]]></kwd>
<kwd lng="es"><![CDATA[Deficiencia de AIRE]]></kwd>
<kwd lng="es"><![CDATA[Proteína humana FEZF2]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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