<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0122-9761</journal-id>
<journal-title><![CDATA[Boletín de Investigaciones Marinas y Costeras - INVEMAR]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Invest. Mar. Cost.]]></abbrev-journal-title>
<issn>0122-9761</issn>
<publisher>
<publisher-name><![CDATA[INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS "JOSE BENITO VIVES DE ANDRÉIS" (INVEMAR)    INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS -JOSE BENITO VIVES DE ANDRÉIS- (INVEMAR)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0122-97612017000200153</article-id>
<article-id pub-id-type="doi">10.25268/bimc.invemar.2017.46.2.730</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Producción de (+)-discodermólido por la esponja Discodermia dissoluta bajo sistemas de cultivo fijo y suspendido]]></article-title>
<article-title xml:lang="en"><![CDATA[Production of (+)-discodermolide by the sponge Discodermia dissoluta under fixed and suspended culture systems]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomez-León]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopez-Navarro]]></surname>
<given-names><![CDATA[Johann]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Millanguir]]></surname>
<given-names><![CDATA[Alicia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castaño]]></surname>
<given-names><![CDATA[Jesus David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zea]]></surname>
<given-names><![CDATA[Sven]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Investigaciones Marinas y Costeras  ]]></institution>
<addr-line><![CDATA[Santa Marta ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Católica de Temuco  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Santa Marta ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>46</volume>
<numero>2</numero>
<fpage>153</fpage>
<lpage>174</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0122-97612017000200153&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0122-97612017000200153&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0122-97612017000200153&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El macrólido antitumoral (+)-discodermólido, producido por la esponja marina Discodermia dissoluta, tiene promisorios resultados como antitumoral, antimitótico e inmunosupresor. Sin embargo, el suministro sostenible de cualquier molécula necesita mucha investigación de trabajo in situ e in vitro para lograr la optimización y posterior obtención de la molécula de interés. En este estudio se evaluaron dos sistemas de cultivo fijo y suspendido a 15 m de profundidad, en las localidades de Punta de Betín y Nenguange en Santa Marta (Caribe colombiano). En cada caso se registró la supervivencia, el crecimiento y la producción de (+)-discodermólido, encontrando mejores resultados para el crecimiento en el sistema suspendido y una dependencia de la supervivencia según la localidad del cultivo. También se estudió la influencia de diferentes factores ambientales sobre la supervivencia, observando una correlación negativa con la temperatura. La salinidad, radiación solar, materia orgánica y flujo del agua no presentaron variaciones importantes, impidiendo establecer una correlación. En cuanto a la producción de (+) -discodermólido, no se encontraron diferencias significativas entre los sistemas y localidades, registrando una producción entre 20-270 pg por gramo de esponja seca.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The macrolide (+)-discodermolide produced by the marine sponge Discodermia dissoluta shows promising antitumor, antimitotic, and immunosuppressive activity. However, the sustainable supply of any molecule requires much in situ and in vitro research to optimize and later obtain the molecule of interest. In this study, two culture systems-fixed and suspended-were evaluated at 15-m depth in two sites, Punta de Betín and Nenguange, in Santa Marta (Colombian Caribbean). Survival, growth, and production of (+)-discodermolide were recorded, with the suspended system resulting in better growth and survival, depending on the culture site. The influence of the different environmental factors on survival was also studied, and a negative correlation with temperature was observed. Salinity, solar radiation, organic matter, and water flow were not correlated. Finally, no significant differences in the production of (+)-discodermolide existed between the culture systems and study sites. Production ranged from 20 to 270 &#956;g per gram of dry sponge.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Discodermia dissoluta]]></kwd>
<kwd lng="es"><![CDATA[(+)-discodermólido]]></kwd>
<kwd lng="es"><![CDATA[Fragmentos de esponja]]></kwd>
<kwd lng="es"><![CDATA[Cultivo de esponjas]]></kwd>
<kwd lng="es"><![CDATA[Acuicultura]]></kwd>
<kwd lng="en"><![CDATA[Discodermia dissoluta]]></kwd>
<kwd lng="en"><![CDATA[(+)-discodermolide]]></kwd>
<kwd lng="en"><![CDATA[Sponge fragments]]></kwd>
<kwd lng="en"><![CDATA[Sponge culture]]></kwd>
<kwd lng="en"><![CDATA[Aquaculture]]></kwd>
</kwd-group>
</article-meta>
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