<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-3122</journal-id>
<journal-title><![CDATA[Persona y Bioética]]></journal-title>
<abbrev-journal-title><![CDATA[pers.bioét.]]></abbrev-journal-title>
<issn>0123-3122</issn>
<publisher>
<publisher-name><![CDATA[Universidad de la Sabana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-31222021000202529</article-id>
<article-id pub-id-type="doi">10.5294/pebi.2021.25.2.9</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[CRISPR-CAS9: EL DEBATE BIOÉTICO MÁS ALLÁ DE LA LÍNEA GERMINAL]]></article-title>
<article-title xml:lang="en"><![CDATA[CRISPR-CAS9: THE BIOETHICAL DEBATE BEYOND THE GERMLINE]]></article-title>
<article-title xml:lang="pt"><![CDATA[CRISPR-CAS9: O DEBATE BIOÉTICO MAIS ALÉM DA LINHAGEM GERMINATIVA]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Infante-López]]></surname>
<given-names><![CDATA[Dilany Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Céspedes-Galvis]]></surname>
<given-names><![CDATA[Mileidy Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wilches-Flórez]]></surname>
<given-names><![CDATA[Ángela María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Distrital Francisco José de Caldas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Distrital Francisco José de Caldas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Distrital Francisco José de Caldas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-31222021000202529&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-31222021000202529&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-31222021000202529&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El sistema CRISPR-Cas9 es una tecnología de edición genética que, además de ampliar las posibilidades en investigación científica, despierta reflexiones asociadas a la dignidad humana, el control biológico, la terapia y la mejora genética. Se revisaron las discusiones bioéticas asociadas a los desafíos y las repercusiones que suscita su aplicación. Como resultado, los cuestionamientos bioéticos tienden a problematizar la aplicación en organismos no humanos, en la investigación básica y en la línea somática y germinal humana. Para concluir, falta incrementar los niveles de seguridad y efectividad para que los beneficios superen los riesgos y, de esta forma, sea posible disminuir las preocupaciones bioéticas y aumentar la credibilidad en el uso de la técnica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The CRISPR-Cas9 system is a genetic editing technology that, in addition to expanding the possibilities for scientific research, promotes reflections associated with human dignity, biological control, therapy, and genetic improvement. Bioethical discussions on the challenges and repercussions of the CRISPR-Cas9 system are reviewed. As a result, bioethical questions tend to problematize the application to non-human organisms, primary research, and the human somatic and germline. In brief, it is necessary to increase the levels of safety and effectiveness so that the benefits outweigh the risks, while reducing bioethical concerns and increasing the credibility of the technique.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O sistema CRISPR-Cas9 é uma tecnologia de edição de genes que, além de ampliar as possibilidades em pesquisa científica, desperta reflexões associadas com a dignidade humana, o controle biológico, a terapia e o aperfeiçoamento genético. Foram revisadas as discussões bioéticas relacionadas aos desafios e às repercussões que sua aplicação suscita. Como resultado, os questionamentos bioéticos tendem a problematizar a aplicação em organismos não humanos, na pesquisa básica e na linhagem somática e germinativa humana. Para concluir, falta aumentar os níveis de segurança e efetividade para que os benefícios sejam maiores do que os riscos, e assim, seja possível diminuir as preocupações bioéticas e aumentar a credibilidade no uso da técnica.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Discusiones bioéticas]]></kwd>
<kwd lng="es"><![CDATA[edición génica]]></kwd>
<kwd lng="es"><![CDATA[efectividad]]></kwd>
<kwd lng="es"><![CDATA[repeticiones palindrómicas cortas agrupadas y regularmente espaciadas]]></kwd>
<kwd lng="es"><![CDATA[riesgos y beneficios]]></kwd>
<kwd lng="es"><![CDATA[medición de riesgo]]></kwd>
<kwd lng="es"><![CDATA[seguridad]]></kwd>
<kwd lng="en"><![CDATA[Bioethical issues]]></kwd>
<kwd lng="en"><![CDATA[clustered regularly interspaced short palindromic repeats]]></kwd>
<kwd lng="en"><![CDATA[effectiveness]]></kwd>
<kwd lng="en"><![CDATA[gene editing]]></kwd>
<kwd lng="en"><![CDATA[risks and fringe benefits]]></kwd>
<kwd lng="en"><![CDATA[Risk Assessment]]></kwd>
<kwd lng="en"><![CDATA[safety]]></kwd>
<kwd lng="pt"><![CDATA[Edição de genes]]></kwd>
<kwd lng="pt"><![CDATA[efetividade]]></kwd>
<kwd lng="pt"><![CDATA[Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas]]></kwd>
<kwd lng="pt"><![CDATA[riscos e benefícios]]></kwd>
<kwd lng="pt"><![CDATA[medição de risco]]></kwd>
<kwd lng="pt"><![CDATA[segurança]]></kwd>
<kwd lng="pt"><![CDATA[temas bioéticos]]></kwd>
</kwd-group>
</article-meta>
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