<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-3122</journal-id>
<journal-title><![CDATA[Persona y Bioética]]></journal-title>
<abbrev-journal-title><![CDATA[pers.bioét.]]></abbrev-journal-title>
<issn>0123-3122</issn>
<publisher>
<publisher-name><![CDATA[Universidad de la Sabana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-31222022000102613</article-id>
<article-id pub-id-type="doi">10.5294/pebi.2022.26.1.3</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Reflections about the Molecular Tool That Could Change the Course of Human History: Genome Editing]]></article-title>
<article-title xml:lang="es"><![CDATA[Reflexiones sobre la herramienta molecular que podría cambiar el curso de la historia humana: la edición genómica]]></article-title>
<article-title xml:lang="pt"><![CDATA[Reflexões sobre as ferramentas moleculares que poderiam mudar o rumo da história humana: a edição de genoma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velasquez-Vasconez]]></surname>
<given-names><![CDATA[Pedro Alexander]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abregu Olarte]]></surname>
<given-names><![CDATA[Wendy Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade de São Paulo  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade de São Paulo  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-31222022000102613&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-31222022000102613&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-31222022000102613&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Genetic editing has many applications in almost all areas of society, but may also lead to unpredictable consequences. Genome editing to modify the human germline is at the center of global discussion. Owing to the increasing number of unanswered scientific, ethical, and policy questions, the scientific community agrees that it would be inappropriate to genetically modify embryos. A serious and open debate is necessary to decide whether such research should be suspended or encouraged. Here we show some bold arguments in favor of deleting deleterious genes from the human genome and the risks liberal eugenism poses.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La edición genética tiene muchas aplicaciones en casi todos los ámbitos de la sociedad, pero también puede tener consecuencias impredecibles. La edición del genoma de la línea germinal humana es el centro de una discusión mundial. Debido al creciente número de cuestionamientos científicos, éticos y políticos, muchos sin una respuesta concreta, el consenso de la comunidad científica manifiesta que sería inapropiado modificar genéticamente embriones humanos. Se considera necesario un debate serio y abierto para decidir si se debe suspender o fomentar la investigación en este sentido. En el presente documento, se exponen algunos argumentos audaces a favor de la eliminación de los genes nocivos del genoma humano y los riesgos que supone el eugenismo liberal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A edição de genoma tem muitas aplicações em todos os âmbitos da sociedade, no entanto pode ter consequências imprevisíveis. A edição do genoma da linha germinal humana é o centro de uma discussão mundial. Devido ao número crescente de questionamentos científicos, éticos e políticos, muitos sem resposta concreta, o consenso da comunidade científica manifesta que não seria apropriado modificar geneticamente embriões humanos. Consideramos que é necessário um debate sério e aberto para decidir se é necessário suspender ou fomentar a pesquisa nesse sentido. Aqui mencionamos alguns argumentos audazes a favor da eliminação de genes nocivos do genoma humano e os riscos decorrentes do eugenismo liberal.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Eugenics]]></kwd>
<kwd lng="en"><![CDATA[designer babies]]></kwd>
<kwd lng="en"><![CDATA[gene therapy]]></kwd>
<kwd lng="en"><![CDATA[mutation]]></kwd>
<kwd lng="en"><![CDATA[therapeutics]]></kwd>
<kwd lng="en"><![CDATA[genetic engineering]]></kwd>
<kwd lng="es"><![CDATA[eugenesia]]></kwd>
<kwd lng="es"><![CDATA[bebé de diseño]]></kwd>
<kwd lng="es"><![CDATA[terapia genética]]></kwd>
<kwd lng="es"><![CDATA[mutación]]></kwd>
<kwd lng="es"><![CDATA[terapéutica]]></kwd>
<kwd lng="es"><![CDATA[ingeniería genética]]></kwd>
<kwd lng="pt"><![CDATA[Eugenia]]></kwd>
<kwd lng="pt"><![CDATA[bebês design]]></kwd>
<kwd lng="pt"><![CDATA[terapia gênica]]></kwd>
<kwd lng="pt"><![CDATA[mutação]]></kwd>
<kwd lng="pt"><![CDATA[terapêutica]]></kwd>
<kwd lng="pt"><![CDATA[engenharia genética]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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