<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-3475</journal-id>
<journal-title><![CDATA[Revista Colombiana de Biotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. biotecnol]]></abbrev-journal-title>
<issn>0123-3475</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Biotecnología, Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-34752020000100060</article-id>
<article-id pub-id-type="doi">10.15446/rev.colomb.biote.v22n1.79999</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Extraction of metabolites from Calendula officinalis and evaluation of their colorant and antibacterial capacity]]></article-title>
<article-title xml:lang="es"><![CDATA[Extracción de metabolitos a partir de Calendula officinalis y evaluación de su capacidad colorante y antibacterial]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Bedoya]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-López]]></surname>
<given-names><![CDATA[Catherine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marín-Pareja]]></surname>
<given-names><![CDATA[Nathalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Servicio Nacional de Aprendizaje  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Servicio Nacional de Aprendizaje  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Servicio Nacional de Aprendizaje  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>22</volume>
<numero>1</numero>
<fpage>60</fpage>
<lpage>69</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-34752020000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-34752020000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-34752020000100060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In this work, different bioactive compounds were obtained by different extractions from Calendula officinalis. The effect of different extraction time and temperature on the quantity of bioactive compounds was investigated. The extracts were quantified by UV-visible spectrometric analysis. The effect of extraction technique on both the colorant power and antibacterial capacity of metabolites obtained was evaluated. Colorant power was evaluated by UV-visible spectrometric and dyeing ability in dairy product. Antibacterial activity of extracts was evaluated using Escherichia coli and Salmonella typhimurium by diffusion technique in well. Outstanding extraction results were obtained by ultrasound extraction technique performed during 2 hours, at 30 °C and ethanol 96% as solvent. The same treatment showed the best result in colorant power and dyeing ability. The extracts obtained by ultrasound had a slightly inhibitory effect of growth on E. coli in comparison with the other techniques. None of the extracts obtained from the different techniques reported a significant inhibition on the growth of S. typhimurium. Therefore, ultrasound-assisted extraction is considered as an alternative process for obtaining the bioactive compounds from C. officinalis with high concentration, colorant power and antibacterial activity.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En este trabajo, diferentes compuestos bioactivos fueron obtenidos a partir de extracciones de las flores de Caléndula officinalis. Se investigó el efecto que tiene el tiempo de extracción y la temperatura sobre la cantidad de compuestos bioactivos. Los extractos obtenidos fueron cuantificados mediante espectrofotometría UV-visible. Se evaluó el efecto de la técnica de extracción sobre el poder colorante y la capacidad antibacterial de los metabolitos obtenidos. El poder colorante se evaluó mediante espectrofotometría UV-visible y la capacidad de teñido se evaluó en un producto lácteo. La actividad antibacterial de los extractos fue evaluada usando Escherichia coli y Salmonella typhimurium mediante la técnica de difusión en pocillos. Se obtuvieron buenas cantidades de metabolitos evaluados mediante la técnica por ultrasonido realizada durante 2 horas, a 30 °C, con etanol a una concentración de 96%. El mismo tratamiento mostro los mejores resultados en cuanto al poder colorante y la capacidad de teñido en una matriz láctea. Los extractos obtenidos por ultrasonido tuvieron un ligero efecto inhibitorio del crecimiento sobre E. coli en comparación con las otras técnicas. Ninguno de los extractos obtenidos mediante las diferentes técnicas mostró una inhibición significativa en el crecimiento de S. typhimurium. Por lo tanto, la extracción asistida por ultrasonido se considera como un proceso alternativo para obtener los compuestos bioactivos de C. officinalis con alta concentración, poder colorante y actividad antibacteriana.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[metabolites]]></kwd>
<kwd lng="en"><![CDATA[dyeing ability]]></kwd>
<kwd lng="en"><![CDATA[antimicrobial activity]]></kwd>
<kwd lng="en"><![CDATA[natural additive]]></kwd>
<kwd lng="en"><![CDATA[common marigold]]></kwd>
<kwd lng="es"><![CDATA[metabolitos]]></kwd>
<kwd lng="es"><![CDATA[capacidad de colorante]]></kwd>
<kwd lng="es"><![CDATA[actividad antimicrobiana]]></kwd>
<kwd lng="es"><![CDATA[aditivo natural]]></kwd>
<kwd lng="es"><![CDATA[caléndula común]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Asero]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multiple intolerance to food additives]]></article-title>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>1993</year>
<volume>110</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>531-5532</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Astley]]></surname>
<given-names><![CDATA[S. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[A. J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Elliott]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Southon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo]]></article-title>
<source><![CDATA[British Journal of Nutrition]]></source>
<year>2004</year>
<volume>91</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>53-61</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Babaee]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Moslemi]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Khalilpour]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Vejdani]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Bijani]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Moghadamnia]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ameri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigation of the effect of Calendula officinalis extract on preventing radiotherapyinduced oral mucositis]]></article-title>
<source><![CDATA[Reports of Radiotherapy and Oncology]]></source>
<year>2013</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bansemir]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Blume]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Schroder]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lindequist]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Screening of Cultivated Seaweeds for Antibacterial Activity against Fish Pathogenic Bacteria]]></article-title>
<source><![CDATA[Aquaculture]]></source>
<year>2006</year>
<volume>252</volume>
<page-range>79-84</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[A.W]]></given-names>
</name>
<name>
<surname><![CDATA[Kirby]]></surname>
<given-names><![CDATA[W.M]]></given-names>
</name>
<name>
<surname><![CDATA[Sherris]]></surname>
<given-names><![CDATA[J.C]]></given-names>
</name>
<name>
<surname><![CDATA[Turck]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibiotic Susceptibility Testing by a Standardized Single Disk Method]]></article-title>
<source><![CDATA[American Journal of Clinical Pathology]]></source>
<year>1966</year>
<volume>45</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>493-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bernal]]></surname>
<given-names><![CDATA[H. Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Quevedo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Pautas para el conocimiento, conservación y uso sostenible de las plantas medicinales nativas en Colombia]]></source>
<year>2011</year>
<publisher-name><![CDATA[Instituto de Investigación de Recursos Biológicos Alexander von Humboldt]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bhatt]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Vyas]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[John]]></surname>
<given-names><![CDATA[P. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Soni]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tartrazine induced neurobiochemical alterations in rat brain subregions]]></article-title>
<source><![CDATA[Food and Chemical Toxicology]]></source>
<year>2018</year>
<volume>113</volume>
<page-range>322-7</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bimakr]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rahman]]></surname>
<given-names><![CDATA[R. A]]></given-names>
</name>
<name>
<surname><![CDATA[Taip]]></surname>
<given-names><![CDATA[F. S]]></given-names>
</name>
<name>
<surname><![CDATA[Ganjloo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Salleh]]></surname>
<given-names><![CDATA[L. M]]></given-names>
</name>
<name>
<surname><![CDATA[Selamat]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zaidul]]></surname>
<given-names><![CDATA[I. S. M]]></given-names>
</name>
</person-group>
<source><![CDATA[Comparison of different extraction methods for the extraction of major bioactive flavonoid compounds from spearmint (Mentha spicata L.) leaves]]></source>
<year>2011</year>
<volume>89</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>67-72</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bissa]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Bohra]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial potential of pot marigold]]></article-title>
<source><![CDATA[Journal of Microbiology and Antimicrobials]]></source>
<year>2011</year>
<volume>3</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>51-554</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biswas]]></surname>
<given-names><![CDATA[A. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sahoo]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Chatli]]></surname>
<given-names><![CDATA[M. K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A simple UV-Vis spectrophotometric method for determination of &#946;-carotene content in raw carrot, sweet potato and supplemented chicken meat nuggets]]></article-title>
<source><![CDATA[LWT - Food Science and Technology]]></source>
<year>2011</year>
<volume>44</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1809-13</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cabello]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Belloso]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparación de dos equipos de extracción por reflujo en la actividad antibacteriana de los extractos acuoso, etanólicolico y clorofórmico de Piper nigrum L]]></article-title>
<source><![CDATA[Revista Cientifica UDO Agricola]]></source>
<year>2009</year>
<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>705-10</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Claros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Determinación de La Actividad Anti-Helicobacter Pylori de Plantago Major (Llantén), Verbena Officinalis (Verbena), Clinopodium Bolivianum (Khoa), Caléndula Officinalis (Caléndula), Piper Angustifolium (Matico) y Rubus Boliviensis (Khari Khari)]]></source>
<year>2005</year>
<publisher-name><![CDATA[Universidad Mayor De San Andres]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cushnie]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Lamb]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial activity of flavonoids]]></article-title>
<source><![CDATA[International Journal of Antimicrobial Agents]]></source>
<year>2005</year>
<volume>26</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>343-56</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Demmig-Adams]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Adams]]></surname>
<given-names><![CDATA[W. W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antioxidants in photosynthesis and human nutrition]]></article-title>
<source><![CDATA[Science]]></source>
<year>2002</year>
<volume>298</volume>
<numero>5601</numero>
<issue>5601</issue>
<page-range>2149-53</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ultraviolet-visible spectrum characterizations of quercetin in aqueous ethanol solution with different pH values]]></article-title>
<source><![CDATA[Journal of Chemical and Pharmaceutical Research]]></source>
<year>2014</year>
<volume>6</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>236-40</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Efstratiou]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Hussain]]></surname>
<given-names><![CDATA[A. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Nigam]]></surname>
<given-names><![CDATA[P. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[J. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Ayub]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[J. R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens]]></article-title>
<source><![CDATA[Complementary Therapies in Clinical Practice]]></source>
<year>2012</year>
<volume>18</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>173-6</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elbanna]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Mohamed]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Khider]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Science Direct evidence for the adverse effects of food azo dyes on rats]]></article-title>
<source><![CDATA[Journal of Food and Drug Analysis]]></source>
<year>2017</year>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gazala]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Murtaza]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Ara]]></surname>
<given-names><![CDATA[Sa.]]></given-names>
</name>
<name>
<surname><![CDATA[Qazi]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Maqbool]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization and antimicrobial activity of some natural dye yielding plant species of Kashmir Valley]]></article-title>
<source><![CDATA[Jr. of Industrial Pollution Control]]></source>
<year>2016</year>
<volume>32</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>518-28</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goktas]]></surname>
<given-names><![CDATA[F. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sahin]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Yigitarslan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology]]></article-title>
<source><![CDATA[International Journal of Analytical Chemistry]]></source>
<year>2015</year>
<page-range>1-18</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gomez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Varon]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Vázquez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio del azafrán (Crocus Satlvus l.) En la provincia de Albacete. II. Color]]></article-title>
<source><![CDATA[Anales de Biologia]]></source>
<year>1987</year>
<volume>13</volume>
<page-range>71-5</page-range><publisher-name><![CDATA[Servicio de Publicaciones de la Universidad de Murcia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kasiram]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sakharkar]]></surname>
<given-names><![CDATA[P. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Patil]]></surname>
<given-names><![CDATA[A. T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antifungal activity of Calendula officinalis]]></article-title>
<source><![CDATA[Indian Journal of Pharmaceutical Sciences]]></source>
<year>2000</year>
<volume>62</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>464-6</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leulescu]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rotaru]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Pãlã rie]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Moanj&#259;]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Cioaterã]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Popescu]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[... Rotaru]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tartrazine: physical, thermal and biophysical properties of the most widely employed synthetic yellow food-colouring azo dye]]></article-title>
<source><![CDATA[Journal of Thermal Analysis and Calorimetry]]></source>
<year>2018</year>
<volume>134</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>209-31</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López-Padilla]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz-Rodriguez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Reglero]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fornari]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Supercritical carbon dioxide extraction of Calendula officinalis: Kinetic modeling and scaling up study]]></article-title>
<source><![CDATA[Journal of Supercritical Fluids]]></source>
<year>2017</year>
<volume>130</volume>
<page-range>292-300</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Luengo]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Condón-Abanto]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Condón]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Raso]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Improving the extraction of carotenoids from tomato waste by application of ultrasound under pressure]]></article-title>
<source><![CDATA[Separation and Purification Technology]]></source>
<year>2014</year>
<volume>136</volume>
<page-range>130-6</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marinova]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Ribarova]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Atanassova]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Total Phenolics and Total Flavonoids in Bulgarian Fruits and Vegetables]]></article-title>
<source><![CDATA[Journal of the University of Chemical Technology and Metallurgy]]></source>
<year>2005</year>
<volume>40</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>255-60</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murugan]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Parimelazhagan]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative evaluation of different extraction methods for antioxidant and anti-inflammatory properties from Osbeckia parvifolia Arn. - An in vitro approach]]></article-title>
<source><![CDATA[Journal of King Saud University - Science]]></source>
<year>2014</year>
<volume>26</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>267-75</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="">
<collab>NCCLS</collab>
<source><![CDATA[M26-A Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline This document provides procedures for determining the lethal activity of antimicrobial agents]]></source>
<year>1999</year>
</nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nicolaus]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Junghanns]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Murillo]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ganzera]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Merfort]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts]]></article-title>
<source><![CDATA[Journal of Ethnopharmacology]]></source>
<year>2017</year>
<volume>196</volume>
<numero>July 2016</numero>
<issue>July 2016</issue>
<page-range>94-103</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Piccaglia]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Marotti]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chiavari]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Gandini]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of harvesting date and climate on the flavonoid and carotenoid contents of marigold (Calendula officinalis L.)]]></article-title>
<source><![CDATA[Flavour and Fragrance Journal]]></source>
<year>1997</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>85-90</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pires]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[M. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Barros]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Calhelha]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Alves]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[M. B.]]></given-names>
</name>
<name>
<surname><![CDATA[... Ferreira]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Edible flowers as sources of phenolic compounds with bioactive potential]]></article-title>
<source><![CDATA[Food Research International]]></source>
<year>2018</year>
<volume>105</volume>
<numero>October 2017</numero>
<issue>October 2017</issue>
<page-range>580-8</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodriguez-Amaya]]></surname>
<given-names><![CDATA[D. B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Update on natural food pigments - A mini-review on carotenoids, anthocyanins, and betalains]]></article-title>
<source><![CDATA[Food Research International]]></source>
<year>2014</year>
<volume>124</volume>
<numero>2017</numero>
<issue>2017</issue>
<page-range>200-5</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodriguez-Concepcion]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Avalos]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Bonet]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Boronat]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Gómez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Hornero-Mendez]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health]]></article-title>
<source><![CDATA[Progress in Lipid Research]]></source>
<year>2018</year>
<volume>70</volume>
<page-range>62-93</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roopashree]]></surname>
<given-names><![CDATA[T. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Dang]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Shobha Rani]]></surname>
<given-names><![CDATA[R. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Narendra]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial activity of antipsoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis]]></article-title>
<source><![CDATA[International Journal of Applied Research in Natural Products]]></source>
<year>2008</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>20-8</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sancho]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pimientos y Pimentón]]></article-title>
<source><![CDATA[Anales de la Universidad de Murcia (Ciencias)]]></source>
<year>1968</year>
<volume>XV</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>6-39</page-range><publisher-name><![CDATA[Universidad de Murcia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Srivastava]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Vankar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carotenoids: As natural food colorant from Canna flowers. 44. 13-18]]></article-title>
<source><![CDATA[Pigment &amp; Resin Technology]]></source>
<year>2015</year>
<volume>1</volume>
<numero>44</numero>
<issue>44</issue>
<page-range>13-8</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tikhomirova]]></surname>
<given-names><![CDATA[Tatiana I.]]></given-names>
</name>
<name>
<surname><![CDATA[Ramazanova]]></surname>
<given-names><![CDATA[Gulselem R.]]></given-names>
</name>
<name>
<surname><![CDATA[Apyari]]></surname>
<given-names><![CDATA[Vladimir V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of Nature and Structure of Synthetic Anionic Food Dyes on Their Sorption onto Different Sorbents: Peculiarities and Prospects]]></article-title>
<source><![CDATA[Microchemical Journal]]></source>
<year>2018</year>
<volume>143</volume>
<page-range>305-11</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vora]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Srivastava]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Modi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial and antioxidant strategies for acne treatment through plant extracts]]></article-title>
<source><![CDATA[Informatics in Medicine Unlocked]]></source>
<year>2018</year>
<volume>13</volume>
<page-range>128-32</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Waage]]></surname>
<given-names><![CDATA[S.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Hedin]]></surname>
<given-names><![CDATA[P.A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quercetin 3-Ogalactosyl-(1-6)-glucoside, a compound from narrowleaf vetch with antibacterial activity]]></article-title>
<source><![CDATA[Phytochemistry]]></source>
<year>1985</year>
<volume>24</volume>
<page-range>243-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
