<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-4226</journal-id>
<journal-title><![CDATA[Revista U.D.C.A Actualidad & Divulgación Científica]]></journal-title>
<abbrev-journal-title><![CDATA[rev.udcaactual.divulg.cient.]]></abbrev-journal-title>
<issn>0123-4226</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Aplicadas y Ambientales]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-42262021000200019</article-id>
<article-id pub-id-type="doi">10.31910/rudca.v24.n2.2021.1681</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad anticoagulante in vitro del extracto etanólico de las hojas de dos especies de la familia Euphorbiaceae]]></article-title>
<article-title xml:lang="en"><![CDATA[In vitro anticoagulant activity of the ethanolic extract of the leaves of two species of the family Euphorbiaceae]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Baquero]]></surname>
<given-names><![CDATA[Jhon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho-Romero]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bolívar-González]]></surname>
<given-names><![CDATA[Samir]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Zafra]]></surname>
<given-names><![CDATA[Álvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Atlántico Facultad de Química y Farmacia Semillero de Investigación Grupo de Investigación Fitoquímica]]></institution>
<addr-line><![CDATA[Barranquilla Atlántico]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Atlántico Facultad de Química y Farmacia Grupo de Investigación Fitoquímica]]></institution>
<addr-line><![CDATA[Barranquilla Atlántico]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Atlántico Facultad de Química y Farmacia Grupo de Investigación Farmacia Asistencial y Farmacología]]></institution>
<addr-line><![CDATA[Barranquilla Atlántico]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad del Atlántico Facultad de Química y Farmacia Semillero de Investigación Grupo de Investigación Administración &amp; Gestión Farmacéutica]]></institution>
<addr-line><![CDATA[Barranquilla Atlántico]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>24</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-42262021000200019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-42262021000200019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-42262021000200019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las enfermedades cardiovasculares (ECV) son un conjunto de trastornos del corazón y de los vasos sanguíneos, que constituyen la principal causa de mortalidad en el mundo. En la búsqueda de alternativas para esta problemática, plantas medicinales de la familia Euphorbiaceae, han sido empeladas con fines terapéuticos, para prevenir, atenuar o curar los efectos generados por estas enfermedades. El objetivo de este trabajo fue conocer el perfil fitoquímico y evaluar la actividad anticoagulante in vitro de los extractos etanólicos de las hojas de Croton malambo y Acalypha hispida sobre plasma humano. Para ello, se obtuvo el extracto de las hojas y se le realizó el tamizaje fitoquímico, la evaluación del Tiempo de Tromboplastina Parcial activada (TTPa) y del Tiempo de Protombina (TP). En el perfil fitoquímico, se confirmó la presencia de alcaloides, taninos, flavonoides, leucoantocianidinas, fenoles, sesquiterpenlactonas, glucósidos cardiotónicos y terpenos. En la actividad anticoagulante, se evidenció la inhibición de la coagulación en la vía intrínseca, obteniendo resultados significativos para el TTPa, a diferencia que el test TP, donde los resultados obtenidos se encontraron similares al control. Esta investigación demuestra la acción anticoagulante de las plantas, ya que induce, significativamente, a una mayor prolongación del tiempo de coagulación; ambas especies presentaron una mayor actividad, a 200 mg/mL.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Cardiovascular diseases (CVD) are a group of disorders of the heart and blood vessels, which correspond to the principal causes of death in the world. In the search for alternatives to this problem, medicinal plants of the Euphorbiaceae family have been investigated for therapeutic purposes to prevent, attenuate or cure the effects generated for these illnesses. The objective of this work was to know the phytochemical profile and evaluate the anticoagulant activity in vitro of the ethanolic extracts of the leaves of Croton malambo and Acalypha hispida on human plasma. For this, extract of their leaves was obtained, and phytochemical screening was performed, as well as the evaluation of the Activated Partial Thromboplastin Time (aPTT) and the Prothrombin Time (TP). The phytochemical profile confirmed the presence of alkaloids, tannins, flavonoids, leucoanthocyanidins, phenols, sesquiterpene lactones, cardiotonic glycosides, and terpenes. In the anticoagulant activity, the inhibition of coagulation in the intrinsic pathway was evidenced, obtaining significant results for aPTT, unlike the TP test where the results obtained were like the control. This research demonstrates the effectiveness of the plant with anticoagulant action since they significantly induce a longer prolongation of the clotting time, both species showed higher activity at 200 mg/mL.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Acalypha hispida]]></kwd>
<kwd lng="es"><![CDATA[Croton malambo]]></kwd>
<kwd lng="es"><![CDATA[Plantas medicinales]]></kwd>
<kwd lng="es"><![CDATA[Tiempo de Tromboplastina Parcial activada]]></kwd>
<kwd lng="es"><![CDATA[Tiempo de Protombina]]></kwd>
<kwd lng="en"><![CDATA[Acalypha hispida]]></kwd>
<kwd lng="en"><![CDATA[Croton malambo]]></kwd>
<kwd lng="en"><![CDATA[Medicinal plants]]></kwd>
<kwd lng="en"><![CDATA[Activated Partial Thromboplastin Time]]></kwd>
<kwd lng="en"><![CDATA[Prothrombin Time]]></kwd>
</kwd-group>
</article-meta>
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