<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9015</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cancerología]]></journal-title>
<abbrev-journal-title><![CDATA[rev.colomb.cancerol.]]></abbrev-journal-title>
<issn>0123-9015</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Cancerología E.S.E.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-90152018000400157</article-id>
<article-id pub-id-type="doi">10.1016/j.rccan.2017.11.002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome meníngeo como primera manifestación de astrocitoma con diferenciación gemistocítica, reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Meningeal syndrome as first manifestation of astrocytoma with gemistocytic differentiation: A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gañan-Vesga]]></surname>
<given-names><![CDATA[Jesús Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ordoñez-Ruiz]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,E.S.E Hospital San Rafael de Tunja Grupo de Investigación Salud San Rafael ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Cauca Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Popayán ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>157</fpage>
<lpage>161</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-90152018000400157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-90152018000400157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-90152018000400157&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El astrocitoma con diferenciación gemistocítica es una variante histológica de los astrocitomas difusos que se caracteriza por presentar tendencia a una rápida progresión hacia la malignidad, y a pesar de ser clasificado según la Organización Mundial de la Salud como un glioma grado II, presenta pobre pronóstico a corto plazo. La presentación clínica más común de este tipo de tumores son los síndromes convulsivos y los déficits focales propios de la localización, mientras que el síndrome de hipertensión endocraneana es poco común. Como primera manifestación se encuentra irritación meníngea más aún en ausencia de infección del sistema nervioso central. Se reporta el caso de un paciente que ingresó a servicio de urgencias con irritación meníngea, a quien finalmente se le diagnostica astrocitoma gemistocitico intraventricular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract An astrocytoma with gemistocytic differentiation is a histological variant of diffuse astrocytomas, characterised by a tendency towards a rapid progression to malignancy. Despite being classified as a grade II glioma according to the World Health Organisation, it has poor short-term prognosis. The most common clinical presentation of these types of tumours are, convulsive syndrome, focal deficits secondary to the location of the tumour, and / or intracranial hypertension syndrome. It is uncommon to find meningeal irritation as a first manifestation, and even more, in the absence of infection of the central nervous system. The case is presented on a patient, who was admitted to the Emergency Department with signs of meningeal irritation. A diagnosis of intraventricular gemistocytic astrocytoma was finally made.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Astrocitoma gemistocítico]]></kwd>
<kwd lng="es"><![CDATA[Irritación meníngea]]></kwd>
<kwd lng="es"><![CDATA[Presentación clínica]]></kwd>
<kwd lng="en"><![CDATA[Astrocytomas gemistocytic]]></kwd>
<kwd lng="en"><![CDATA[Meningeal irritation]]></kwd>
<kwd lng="en"><![CDATA[Clinical presentation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Watanabe]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Peraud]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gratas]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wakai]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[p53 and PTEN gene mutations in gemistocytic astrocytomas]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Kleihues]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ohgaki]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Acta Neuropathol]]></source>
<year>1998</year>
<volume>95</volume>
<page-range>559-64</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Babu]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bagley]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Friedman]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Adamson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low-grade astrocytomas the prognostic value of fibrillary, gemistocytic, and protoplasmic tumor histology]]></article-title>
<source><![CDATA[J Neurosurg]]></source>
<year>2013</year>
<volume>119</volume>
<page-range>434-41</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elvidge]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Penfield]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Cone]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[The gliomas of the central nervous system: a study of two hundred and ten verified cases]]></source>
<year>1935</year>
<publisher-name><![CDATA[Montreal Neurological Institute]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoshino]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[BC]]></given-names>
</name>
<name>
<surname><![CDATA[Ellis]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gemistocytic astrocytes in gliomas An autoradiographic study]]></article-title>
<source><![CDATA[J Neuropathol Exp Neurol]]></source>
<year>1975</year>
<volume>34</volume>
<page-range>263-81</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nissl]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Zur histopathologie der paralytischen rindenerkrankung]]></article-title>
<source><![CDATA[Histol Histopathol Arb Grosshirn]]></source>
<year>1904</year>
<volume>1</volume>
<page-range>315</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tihan]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vohra PBerger]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Keles]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Definition and diagnostic implications of gemistocytic astrocytomas a pathological perspective]]></article-title>
<source><![CDATA[J Neurooncol]]></source>
<year>2006</year>
<volume>76</volume>
<page-range>175-83</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Krouwer]]></surname>
<given-names><![CDATA[HG]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Silver]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Prados]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gemistocytic astrocytomas a reappraisal]]></article-title>
<source><![CDATA[Journal of neurosurg]]></source>
<year>1991</year>
<volume>74</volume>
<page-range>399-406</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Avninder]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Deb]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mehta]]></surname>
<given-names><![CDATA[VS]]></given-names>
</name>
<name>
<surname><![CDATA[Karak]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Mahapatra]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gemistocytic astrocytomas histomorphology, proliferative potential and genetic alterations -a study of 32 cases]]></article-title>
<source><![CDATA[J Neurooncol]]></source>
<year>2006</year>
<volume>78</volume>
<page-range>123-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ropper]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<source><![CDATA[Adams and Victor&#8217;s Principles of Neurology]]></source>
<year>2005</year>
<edition>8</edition>
<publisher-loc><![CDATA[Edition New York ]]></publisher-loc>
<publisher-name><![CDATA[McGraw-Hill Medical Pub]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Abbas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Aster]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Robbins basic pathology]]></source>
<year>2012</year>
<edition>9</edition>
<publisher-name><![CDATA[Edition Elsevier Health Sciences]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Strayer]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Rubin&#8217;s Pathology: Clinicopathologic Foundations of Medicine]]></source>
<year>2008</year>
<edition>5</edition>
<publisher-loc><![CDATA[Edition Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Lippincott Williams &amp; Wilkins]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rusell Rubenstein]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Pathology of tumours of the nervous system]]></source>
<year>1989</year>
<publisher-name><![CDATA[Taylor &amp; Francis]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanai]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Berger]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extent of resection influences outcomes for patients with gliomas]]></article-title>
<source><![CDATA[Rev Neurol]]></source>
<year>2011</year>
<volume>167</volume>
<page-range>648-54</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Paek]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The significance of gemistocytes in astrocytoma]]></article-title>
<source><![CDATA[Acta Neurochir]]></source>
<year>2003</year>
<volume>145</volume>
<page-range>1097-103</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Penagos]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Zubieta]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Romero Rojas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Guevara]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actualidad en la patología y tratamiento de los gangliogliomas ¡un tumor no tan benigno!]]></article-title>
<source><![CDATA[Acta Neurol Colomb]]></source>
<year>2010</year>
<volume>26</volume>
<page-range>112-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robert]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Sajadi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Uské]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Levivier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bloch]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fulminant meningoencephalitis as the first clinical sign of an invasive pituitary macroadenoma]]></article-title>
<source><![CDATA[Case Rep Neurol]]></source>
<year>2010</year>
<volume>2</volume>
<page-range>133-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boscolo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baleriaux]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bakoto]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Corvilain]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Devuyst]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute aseptic meningitis as the initial presentation of a macroprolactinoma]]></article-title>
<source><![CDATA[BMC Res Notes]]></source>
<year>2014</year>
<volume>7</volume>
<page-range>9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
