<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9015</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cancerología]]></journal-title>
<abbrev-journal-title><![CDATA[rev.colomb.cancerol.]]></abbrev-journal-title>
<issn>0123-9015</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Cancerología E.S.E.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-90152022000100003</article-id>
<article-id pub-id-type="doi">10.35509/01239015.702</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sedación paliativa en enfermedad terminal]]></article-title>
<article-title xml:lang="en"><![CDATA[Palliative sedation in terminal desease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero Carreño]]></surname>
<given-names><![CDATA[Valeria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Vásquez]]></surname>
<given-names><![CDATA[Catalina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Agámez lnsignares]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Militar Nueva Granada Instituto Nacional de Cancerología ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Sabana Instituto Nacional de Cancerología ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Cancerología  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>1</numero>
<fpage>3</fpage>
<lpage>13</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-90152022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-90152022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-90152022000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Algunos pacientes con enfermedad terminal que están cerca del final de la vida pueden experimentar un sufrimiento intolerable dado por síntomas refractarios a las terapias paliativas específicas. La Sedación Paliativa (SP) se considera una modalidad de tratamiento eficaz para el manejo de estos síntomas refractarios cuando los esfuerzos agresivos no proporcionan alivio. La SP consiste en el uso de medicamentos que inducen sedación y disminución del nivel de conciencia con el objetivo de aliviar el sufrimiento intolerable en los últimos días de la vida. Los síntomas físicos refractarios más frecuentes son el dolor, delirium y disnea, sin embargo, la SP también se indica para tratar el sufrimiento existencial o la angustia psicológica, que es un problema extremadamente difícil y delicado. La SP ha sido ampliamente debatida por las obvias implicaciones éticas, socioculturales y de toma de decisiones. Se ha reportado que la SP se administra en una proporción que va del 2% al 52% de los pacientes con enfermedades terminales. Los estudios han sugerido que la SP es exitosa en el manejo de los síntomas intratables al final de la vida, no genera efectos perjudiciales sobre la supervivencia y es satisfactoria para los familiares.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Palliative sedation (PS) is frequently applied in some patients with terminal illness, who are near the end of life, to ameliorate unendurable and refractory distress; it is considered an effective treatment modality for the management of refractory symptoms when aggressive efforts do not provide relief. PS consists of the use of medications that induce sedation and decrease the level of consciousness with the aim of relieving intolerable suffering in the last days of life. The most frequent physical refractory symptoms are pain, delirium, and dyspnea, but PS is also indicated to treat existential suffering or psychological distress, which is an extremely difficult and delicate problem. PS has been widely debated given its obvious ethical, sociocultural, and decision-making implications. It has been reported that PS is given to 2-52% of patients with terminal illness; studies have suggested that PS is successful in managing intractable symptoms at the end of life, satisfactory for family members, and does not have detrimental effects on survival.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sedación]]></kwd>
<kwd lng="es"><![CDATA[final de la vida]]></kwd>
<kwd lng="es"><![CDATA[cuidados paliativos]]></kwd>
<kwd lng="es"><![CDATA[síntomas refractarios]]></kwd>
<kwd lng="es"><![CDATA[enfermedad terminal]]></kwd>
<kwd lng="es"><![CDATA[sufrimiento]]></kwd>
<kwd lng="en"><![CDATA[sedation]]></kwd>
<kwd lng="en"><![CDATA[end of life]]></kwd>
<kwd lng="en"><![CDATA[palliative care]]></kwd>
<kwd lng="en"><![CDATA[refractory symptoms]]></kwd>
<kwd lng="en"><![CDATA[terminal illness]]></kwd>
<kwd lng="en"><![CDATA[suffering]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Claessens]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Menten]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schotsmans]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Broeckaert]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative Sedation: A Review of the Research Literature]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2008</year>
<volume>36</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>310-33</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bodnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bodnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Review of Agents for Palliative Sedation/Continuous Deep Sedation: Pharmacology and Practical Applications A Review of Agents for Palliative Sedation / Continuous Deep Sedation : Pharmacology and Practical Applications]]></article-title>
<source><![CDATA[J Pain Palliat Care Pharmacother]]></source>
<year>2017</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>16-37</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Enck]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-induced terminal sedation for symptom control]]></article-title>
<source><![CDATA[Am J Hosp Palliat Med]]></source>
<year>1991</year>
<volume>8</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>3-5</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Have]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Welie]]></surname>
<given-names><![CDATA[JVM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative Sedation Versus Euthanasia: An Ethical Assessment]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2019</year>
<volume>47</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>123-36</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trota]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Aguilar]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Flores]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Pozo]]></surname>
<given-names><![CDATA[RRDEL]]></given-names>
</name>
<name>
<surname><![CDATA[Aguirre]]></surname>
<given-names><![CDATA[YV]]></given-names>
</name>
</person-group>
<source><![CDATA[Aspectos éticos de la sedación en Cuidados Paliativos*]]></source>
<year>2002</year>
<volume>9</volume>
<page-range>41-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastrana]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[De Lima]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pons]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Centeno]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Atlas de Cuidados Paliativos en Latinoamérica- Edición Cartográfica 2013]]></source>
<year>2013</year>
<page-range>1-72</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Della Valle]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Barlocco]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Pereyra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bonilla]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sedación paliativa: experiencia en una unidad de cuidados paliativos de Montevideo]]></article-title>
<source><![CDATA[Rev Médica del Uruguay]]></source>
<year>2009</year>
<volume>25</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>78-83</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parra Palacio]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Giraldo Hoyos]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
<name>
<surname><![CDATA[Arias Rodríguez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mejía Arrieta]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Vargas Gómez]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Krikorian]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative sedation in advanced cancer patients hospitalized in a specialized palliative care unit]]></article-title>
<source><![CDATA[Support Care Cancer]]></source>
<year>2018</year>
<volume>26</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>3173-80</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cherny]]></surname>
<given-names><![CDATA[NI]]></given-names>
</name>
<name>
<surname><![CDATA[Radbruch]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chasen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Coyle]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Charles]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dean]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[European Association for Palliative Care (EAPC) recommended framework for the use of sedation in palliative care]]></article-title>
<source><![CDATA[Palliat Med]]></source>
<year>2009</year>
<volume>23</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>581-93</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanchez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cuervo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guia Clinica. Sedacion del prcpex, uso y recomendaciones]]></article-title>
<source><![CDATA[Programa Reg Cuid Paliativos Extrem]]></source>
<year>2014</year>
<page-range>91</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palliative]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Shorten]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Lives THE, Patients OF. ¿La sedación paliativa acorta la vida de los pacientes?]]></source>
<year>2017</year>
<page-range>204-18</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
<name>
<surname><![CDATA[Sakata]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
</person-group>
<source><![CDATA[Sedación Paliativa del Paciente Terminal]]></source>
<year>2012</year>
<volume>62</volume>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Henry]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[A systematic literature rewew on the ethics of palliative sedation: an update (2016)]]></source>
<year>2016</year>
<volume>6100</volume>
<page-range>201-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maltoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Setola]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Palliative Sedation in Patients With Cancer]]></source>
<year>2015</year>
<page-range>433-41</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cherny]]></surname>
<given-names><![CDATA[NI]]></given-names>
</name>
<name>
<surname><![CDATA[Guidelines]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Group]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ESMO Clinical Practice Guidelines for the management of refractory symptoms at the end of life and the use of palliative sedation]]></article-title>
<source><![CDATA[ESMO Updat Clin Pract Guidel]]></source>
<year>2014</year>
<volume>25</volume>
<page-range>iii143-52</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morrison]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Youngwerth]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative Sedation Therapy]]></article-title>
<source><![CDATA[Hosp Med Clin]]></source>
<year>2016</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>101-13</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bobb]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Review of Palliative Sedation]]></article-title>
<source><![CDATA[Nurs Clin NA]]></source>
<year>2016</year>
<volume>51</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>449-57</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muller-Busch]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[Andres]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Jehser]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sedation in palliative care - A critical analysis of 7 years experience]]></article-title>
<source><![CDATA[BMC Palliat Care]]></source>
<year>2003</year>
<volume>2</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teunissen]]></surname>
<given-names><![CDATA[SCCM]]></given-names>
</name>
<name>
<surname><![CDATA[Wesker]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Kruitwagen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[de Haes]]></surname>
<given-names><![CDATA[HCJM]]></given-names>
</name>
<name>
<surname><![CDATA[Voest]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[de Graeff]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2007</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>94-104</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maltoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Scarpi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nanni]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Palliative sedation for intolerable suffering]]></source>
<year>2014</year>
<page-range>389-94</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mercadante]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Porzio]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Valle]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fusco]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Aielli]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Costanzo]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative sedation in patients with advanced cancer followed at home: A systematic review]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2011</year>
<volume>41</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>754-60</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[HN]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[US]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[GW]]></given-names>
</name>
<name>
<surname><![CDATA[Hwang]]></surname>
<given-names><![CDATA[IG]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Eduardo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-Term Intermittent Palliative Sedation for Refractory Symptoms at the End of Life in Two Cancer Patients]]></article-title>
<source><![CDATA[Palliat Med]]></source>
<year>2015</year>
<volume>18</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>807-10</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garetto]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cancelli]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rossi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Maltoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative Sedation for the Terminally Ill Patient]]></article-title>
<source><![CDATA[CNS Drugs]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruera]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hui]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dalal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Torres-Vigil]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Trumble]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Roosth]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Parenteral hydration in patients with advanced cancer: A multicenter, double-blind, placebo-controlled randomized trial]]></article-title>
<source><![CDATA[J Clin Oncol]]></source>
<year>2013</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>111-8</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Textbook]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Palliative Nursing. Palliat Nurs]]></source>
<year>2009</year>
<page-range>440-8</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruce]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Boston]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Relieving existential suffering through palliative sedation: Discussion of an uneasy practice]]></article-title>
<source><![CDATA[J Adv Nurs]]></source>
<year>2011</year>
<volume>67</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2732-40</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Graeff]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dean]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative sedation therapy in the last weeks of life: A literature review and recommendations for standards]]></article-title>
<source><![CDATA[Palliat Med]]></source>
<year>2007</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>67-85</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kirk]]></surname>
<given-names><![CDATA[TW]]></given-names>
</name>
<name>
<surname><![CDATA[Mahon]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[National Hospice and Palliative Care Organization (NHPCO) Position Statement and Commentary on the Use of Palliative Sedation in Imminently Dying Terminally Ill Patients]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2010</year>
<volume>39</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>914-23</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Booker]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bruce]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative sedation and medical assistance in dying: Distinctly different or simply semantics?]]></article-title>
<source><![CDATA[Nurs Inq]]></source>
<year>2020</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="">
<collab>Statement on Palliative Sedation</collab>
<source><![CDATA[Palliat Med]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Back]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
<name>
<surname><![CDATA[Bunch]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Marr]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Wallace]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[HB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Communication about cancer near the end of life]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>2008</year>
<volume>113</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1897-910</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carmona-espinazo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-prieto]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[REVISTA ESPAÑOLA DE Nuestra experiencia en sedación paliativa como opción terapéutica en pacientes en situación clínica de últimos días]]></article-title>
<source><![CDATA[Rev Española Med Leg]]></source>
<year>2016</year>
<numero>xx</numero>
<issue>xx</issue>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tapiero]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
</person-group>
<source><![CDATA[La sedación terminal. Aspectos éticos]]></source>
<year>2003</year>
<volume>20</volume>
<page-range>645-9</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sulistio]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wojnar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Michael]]></surname>
<given-names><![CDATA[NG]]></given-names>
</name>
</person-group>
<source><![CDATA[Propofol for palliative sedation]]></source>
<year>2019</year>
<page-range>1-3</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deol]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Dimtri]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Minaie]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Surani]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Udeani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of Ramsay Sedation Scale in Sedative Dosage Modulation for Critically-Ill Intubated Patients]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2017</year>
<volume>152</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>A330</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deol]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Surani]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Udeani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inter-rater Reliability of the Ramsay Sedation Scale for Critically-ill Intubated Patients]]></article-title>
<source><![CDATA[Cureus]]></source>
<year>2019</year>
<volume>11</volume>
<numero>10</numero>
<issue>10</issue>
</nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ely]]></surname>
<given-names><![CDATA[EW]]></given-names>
</name>
<name>
<surname><![CDATA[Truman]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Thomason]]></surname>
<given-names><![CDATA[JWW]]></given-names>
</name>
<name>
<surname><![CDATA[Wheeler]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Francis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Monitoring Sedation Status Over Time in ICU Patients]]></source>
<year>2014</year>
<volume>289</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>2983-91</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maltoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Scarpi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rosati]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Derni]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fabbri]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Martini]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative sedation in end-of-life care and survival: A systematic review]]></article-title>
<source><![CDATA[J Clin Oncol]]></source>
<year>2012</year>
<volume>30</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1378-83</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prado]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
<name>
<surname><![CDATA[Bugano]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Luiz]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Usón]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Taranto]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Continuous palliative sedation for patients with advanced cancer at a tertiary care cancer center]]></source>
<year>2018</year>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jansen]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disambiguating clinical intentions: The ethics of palliative sedation]]></article-title>
<source><![CDATA[J Med Philos]]></source>
<year>2010</year>
<volume>35</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>19-31</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mercadante]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Intravaia]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Villari]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrera]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dawd]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Casuccio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Controlled Sedation for Refractory Symptoms in Dying Patients]]></article-title>
<source><![CDATA[J Pain Symptom Manage]]></source>
<year>2009</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>771-9</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chessa]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Ethical and Legal Considerations in End-of- Life Care]]></source>
<year>2019</year>
<volume>46</volume>
<page-range>387-98</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berger]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The proportionate value of proportionality in palliative sedation]]></article-title>
<source><![CDATA[J Clin ethics]]></source>
<year>2014</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>219-21</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Beller]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[van Driel]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Mcgregor]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Truong]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Mitchell]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palliative pharmacological sedation for terminally ill adults]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2015</year>
<volume>2017</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Taboada]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sedación paliativa (parte ii). cuestiones éticas y principios morales 1]]></article-title>
<source><![CDATA[Acta Bioeth]]></source>
<year>2014</year>
<volume>20</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>225-35</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raijmakers]]></surname>
<given-names><![CDATA[NJH]]></given-names>
</name>
<name>
<surname><![CDATA[van Zuylen]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Costantini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Caraceni]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lundquist]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects]]></article-title>
<source><![CDATA[Ann Oncol]]></source>
<year>2011</year>
<volume>22</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1478-86</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gurschick]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Mayer]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
<name>
<surname><![CDATA[Hanson]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
</person-group>
<source><![CDATA[Palliative Sedation: An Analysis of International Guidelines and Position Statements]]></source>
<year>2015</year>
<volume>32</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>660-71</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dev]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Dalal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bruera]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is there a role for parenteral nutrition or hydration at the end of life?]]></article-title>
<source><![CDATA[Curr Opin Support Palliat Care]]></source>
<year>2012</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>365-70</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[HPNA Position Paper: Palliative Sedation at the End of Life]]></article-title>
<source><![CDATA[J Hosp Palliat Nurs]]></source>
<year>2003</year>
<volume>5</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>235-7</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[One]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Artificial Nutrition and Hydration in End-of-Life Care HPNA Position Paper Approved]]></article-title>
<source><![CDATA[Hosp Today]]></source>
<year>2004</year>
<volume>22</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>341-5</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quill]]></surname>
<given-names><![CDATA[TE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Responding to Intractable Terminal Suffering]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2000</year>
<volume>133</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>561</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
