<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922017000200117</article-id>
<article-id pub-id-type="doi">10.22354/in.v21i2.655</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Epidemiología molecular del virus de la hepatitis C]]></article-title>
<article-title xml:lang="en"><![CDATA[Hepatitis C virus: A global public health problem]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salvatierra]]></surname>
<given-names><![CDATA[Karina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Distrital Francisco José de Caldas Grupo de investigación Innovación en Tecnologías de Información ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<fpage>117</fpage>
<lpage>125</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922017000200117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922017000200117&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922017000200117&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La infección crónica provocada por el virus de la hepatitis C (VHC) sigue siendo un gran problema de salud pública a nivel mundial, afecta a unos 200 millones de personas en el mundo. Se trata de la primera primera causa de trasplante y de muerte de origen hepático. La evolución natural de la enfermedad es el desarrollo de cirrosis y el riesgo de desarrollo de hepatocarcinoma. Es una enfermedad silenciosa, cuyo diagnóstico mediante la clínica supone detectarla en fases avanzadas. El diagnóstico inicial se realiza mediante la detección de anticuerpos anti-VHC y se confirma demostrando la replicación viral. La indicación de tratamiento se establece tras la evaluación del grado de fibrosis y el genotipo de VHC que ha infectado al paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Chronic infection caused by the hepatitis C virus (HCV) continues to be a public health problem worldwide, affecting about 200 million people worldwide. This is the first leading cause of death and transplantation of hepatic origin. The natural course of the disease is the development of cirrhosis and hepatocellular carcinoma risk development. It is an silent disease, whose diagnosis by clinical signs supposed to detect in advanced stages. The initial diagnosis is made by detecting antibodies anti-HCV and confirmed by demonstrating viral replication. The indication for treatment is established after assessing the degree of fibrosis and HCV genotype has infected the patient.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hepatitis C]]></kwd>
<kwd lng="es"><![CDATA[cirrosis]]></kwd>
<kwd lng="es"><![CDATA[hepatocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[hepatitis C]]></kwd>
<kwd lng="en"><![CDATA[cirrhosis]]></kwd>
<kwd lng="en"><![CDATA[hepatocellular carcinoma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choo]]></surname>
<given-names><![CDATA[QL]]></given-names>
</name>
<name>
<surname><![CDATA[Kuo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Weiner]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[KS]]></given-names>
</name>
<name>
<surname><![CDATA[Overby]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bradley]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>1989</year>
<volume>244</volume>
<page-range>359-62</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Identification of the major, pare nteral non-A, non-B hepatitis agent (hepatitis C virus) using a recombinant cDNA approach]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choo]]></surname>
<given-names><![CDATA[QL]]></given-names>
</name>
<name>
<surname><![CDATA[Kuo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Weiner]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[KS]]></given-names>
</name>
<name>
<surname><![CDATA[Overby]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bradley]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Houghton]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin Liver Dis]]></source>
<year>1992</year>
<volume>12</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>279-88</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kuo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Choo]]></surname>
<given-names><![CDATA[QL]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gitnick]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Redeker]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>1989</year>
<volume>244</volume>
<page-range>362-4</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Bukh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Combet]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Deléage]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Enomoto]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Feinstone]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Halfon]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Inchauspé]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Kuiken]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Maertens]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2005</year>
<volume>42</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>962-73</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Replication of hepatitis C virus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moradpour]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Penin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Microbiol]]></source>
<year>2007</year>
<volume>5</volume>
<page-range>453-63</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ultrastructural analysis of hepatitis C virus particles]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Catanese]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Uryu]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kopp]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Andrus]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Silvestry]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kuhn]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2013</year>
<volume>110</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>9505-10</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Qiao]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Atanasov]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Kato]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[ZH]]></given-names>
</name>
</person-group>
<source><![CDATA[Virology]]></source>
<year>2007</year>
<volume>367</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>126-34</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Assembly of infectious hepatitis C virus particles]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bartenschlager]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Penin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Lohmann]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Microbiol]]></source>
<year>2011</year>
<volume>19</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>95-103</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machlin]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Sarnow]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Sagan]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2011</year>
<volume>108</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>3193-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shimakami]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Yamane]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jangra]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
<name>
<surname><![CDATA[Kempf]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Spaniel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Barton]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci USA]]></source>
<year>2012</year>
<volume>109</volume>
<page-range>941-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shimakami]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Yamane]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Welsch]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hensley]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jangra]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
<name>
<surname><![CDATA[Lemon]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<source><![CDATA[J Virol]]></source>
<year>2012</year>
<volume>86</volume>
<page-range>7372-83</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Masaki]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[miR-122 and the Hepatitis C RNA genome: more than just stability RNA]]></article-title>
<collab>Lemon SM</collab>
<source><![CDATA[Biol]]></source>
<year>2013</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>919-23</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Structural basis of RNA recognition and activation by innate immune receptor RIG-I]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Ramanathan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[GQ]]></given-names>
</name>
<name>
<surname><![CDATA[Gale]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2011</year>
<volume>479</volume>
<page-range>423-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Endoplasmic Reticulum (ER) stress hepatitis C virus induces and ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Waris]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Tardif]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Siddiqui]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem Pharmacol]]></source>
<year>2002</year>
<volume>64</volume>
<page-range>1425-30</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The hepatitis C virus alternate reading frame (ARF) and its family of novel products the alternate reading frame protein/F-protein, the double-frameshift protein, and others]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Branch]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Stump]]></surname>
<given-names><![CDATA[DD]]></given-names>
</name>
<name>
<surname><![CDATA[Gutierrez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Eng]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Walewski]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2005</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>105-17</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evidence for a functional RNA element in the hepatitis C virus core gene]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[McMullan]]></surname>
<given-names><![CDATA[LK]]></given-names>
</name>
<name>
<surname><![CDATA[Grakoui]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Mihalik]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Puig]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Branch]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Feinstone]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2007</year>
<volume>104</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2879-84</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antigenic relevance of F protein in chronic hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Komurian-Pradel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rajoharison]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Berland]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Khouri]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Perret]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Van Roosmalen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pol]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Negro]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Paranhos-Baccalà]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2004</year>
<volume>40</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>900-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Assembly of a functional HCV glycoprotein heterodimer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lavie]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Goffard]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dubuisson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr. Issues Mol. Biol]]></source>
<year>2007</year>
<volume>9</volume>
<page-range>71 86</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carrère-Kremer]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Montpellier]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lorenzo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Brulin]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Cocquerel]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Belouzard]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Penin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Dubuisson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>2004</year>
<volume>279</volume>
<page-range>41384 92</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Steinmann]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Penin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Kallis]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Bartenschlager]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pietschmann]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS Pathog]]></source>
<year>2007</year>
<volume>3</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>e103</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wozniak]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Griffin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rowlands]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Harris]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lemon]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Weinman]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS Pathog]]></source>
<year>2010</year>
<volume>6</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>e1001087</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Enomoto]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sakuma]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Asahina]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kurosaki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Murakami]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Yamamoto]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ogura]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Izumi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Marumo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sato]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>1996</year>
<volume>334</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>77-81</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Molecular viral oncology of hepatolellular carcinoma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Block]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Mehta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fimmel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jordan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Oncogene]]></source>
<year>2003</year>
<volume>22</volume>
<page-range>5093-107</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nucleotide sequence and mutation rate of the H strain of hepatitis C virus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ogata]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>1991</year>
<volume>88</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>3392-6</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pacing a small cage mutation and RNA viruses]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Belshaw]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gardner]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rambaut]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pybus]]></surname>
<given-names><![CDATA[OG]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Ecol Evol]]></source>
<year>2008</year>
<volume>23</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>188-93</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Replication of hepatitis C virus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bartenschlager]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lohmann]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[J Gen Virol]]></source>
<year>2000</year>
<volume>81</volume>
<page-range>1631-48.27</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Rates of evolutionary change inviruses patterns and determinants]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duffy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Shackelton]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Holmes]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Genet]]></source>
<year>2008</year>
<volume>9</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>267-76</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dosedependent acute clearance of hepatitis C genotype 1 virus with interferon alfa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lam]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
<name>
<surname><![CDATA[Neumann]]></surname>
<given-names><![CDATA[AU]]></given-names>
</name>
<name>
<surname><![CDATA[Gretch]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Wiley]]></surname>
<given-names><![CDATA[TE]]></given-names>
</name>
<name>
<surname><![CDATA[Perelson]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Layden]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>1997</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>226-31</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hepatitis C virus (HCV) circulates as a population of different but closely related genomes quasispecies nature of HCV genome distribution]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martell]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Esteban]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
<name>
<surname><![CDATA[Quer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Genescà]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Weiner]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Esteban]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Guardia]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[J Virol]]></source>
<year>1992</year>
<volume>66</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>3225-9</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical Relevance of Genetic Heterogeneity in HCV Future]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[González-Candelas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[López-Labrador]]></surname>
<given-names><![CDATA[FX]]></given-names>
</name>
</person-group>
<source><![CDATA[Virology]]></source>
<year>2010</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-49</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The origin of hepatitis C virus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Top Microbiol Immunol]]></source>
<year>2013</year>
<volume>369</volume>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes updated criteria and genotype assignment Web resource]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
<name>
<surname><![CDATA[Bukh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kuiken]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Muerhoff]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Stapleton]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2014</year>
<volume>59</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>318-27</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A proposed system for the nomenclature of hepatitis C viral genotypes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Alberti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bonino]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bradley]]></surname>
<given-names><![CDATA[DW]]></given-names>
</name>
<name>
<surname><![CDATA[Brechot]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Brouwer]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Chayama]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>1994</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1321-4</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tamura]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Peterson]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Peterson]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Stecher]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Nei]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Molecular Biology and Evolution (submitted)]]></source>
<year>2011</year>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical significance of hepatitis C virus genotypes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zein]]></surname>
<given-names><![CDATA[NN]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Microbio Rev]]></source>
<year>2000</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>223-35</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The changing epidemiology of hepatitis C virus infection in Europe]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esteban]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
<name>
<surname><![CDATA[Sauleda]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Quer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[J Hepatol]]></source>
<year>2008</year>
<volume>48</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>148-62</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiology of hepatitis C virus (HCV) infection Int J Med]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sy]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Jamal]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<source><![CDATA[Sci]]></source>
<year>2006</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>41-6</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cornberg]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Razavi]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Alberti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bernasconi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Buti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Dalgard]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Dillion]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
</person-group>
<source><![CDATA[Liver Int]]></source>
<year>2011</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>30-60</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Different seroprevalence and molecular epidemiology patterns ofhepatitis C virus infection in Italy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ansaldi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bruzzone]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Salmaso]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rota]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Durando]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gasparini]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Icardi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[J Med Virol]]></source>
<year>2005</year>
<volume>76</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>327-32</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt a Bayesian coalescent approach]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pybus]]></surname>
<given-names><![CDATA[OG]]></given-names>
</name>
<name>
<surname><![CDATA[Drummond]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Nakano]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Robertson]]></surname>
<given-names><![CDATA[BH]]></given-names>
</name>
<name>
<surname><![CDATA[Rambaut]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol Biol Evol]]></source>
<year>2003</year>
<volume>20</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>381-7</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genotyping of hepatitis C virus in South Africa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smuts]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
<name>
<surname><![CDATA[Kannemeyer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Microbiol]]></source>
<year>1995</year>
<volume>33</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1679 81</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chronic hepatitis C virus genotype 6 infection response to pegylated interferon and ribavirin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fung]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lai]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Hung]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Yuen]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
</person-group>
<source><![CDATA[J Infect Dis]]></source>
<year>2008</year>
<volume>198</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>808-12</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The global spread of hepatitis C virus 1a and 1b a phylodynamic and phylogeographic analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Magiorkinis]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Magiorkinis]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Paraskevis]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ho]]></surname>
<given-names><![CDATA[SY]]></given-names>
</name>
<name>
<surname><![CDATA[Shapiro]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Pybus]]></surname>
<given-names><![CDATA[OG]]></given-names>
</name>
<name>
<surname><![CDATA[Allain]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Hatzakis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS Med]]></source>
<year>2009</year>
<volume>6</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>e1000198</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Does hepatitis C virus really form quasispecies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Holmes]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
</person-group>
<source><![CDATA[Infect Genet Evol]]></source>
<year>2010</year>
<volume>10</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>431-2</page-range></nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical significance of hepatitis C virus genotypes and quasispecies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farci]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2000</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>103-26</page-range></nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sampling and repeatability in the evaluation of hepatitis C virus genetic variability]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres-Puente]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bracho]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[García-Robles]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Moya]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[González-Candelas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[J Gen Virol]]></source>
<year>2003</year>
<volume>84</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2343-50</page-range></nlm-citation>
</ref>
<ref id="B47">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gretch]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Polyak]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Carithers Jr]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Perkins]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Corey]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[J Virol]]></source>
<year>1996</year>
<volume>70</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>7622-31</page-range></nlm-citation>
</ref>
<ref id="B48">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sequencing technologies-the next generation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metzker]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Genet]]></source>
<year>2010</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>31-46</page-range></nlm-citation>
</ref>
<ref id="B49">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[New virologic tools for management of chronic hepatitis B and C]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chevaliez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Gastroenterology]]></source>
<year>2012</year>
<volume>142</volume>
<numero>1303</numero>
<issue>1303</issue>
<page-range>1313.e1</page-range></nlm-citation>
</ref>
<ref id="B50">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resistance to direct antiviral agents in patients with hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sarrazin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Zeuzem]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Gastroenterology]]></source>
<year>2010</year>
<volume>138</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>447-62</page-range></nlm-citation>
</ref>
<ref id="B51">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antiviral resistance and specifically targeted therapy for HCV (STAT-C)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thompson]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[McHutchison]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
</person-group>
<source><![CDATA[J Viral Hepat]]></source>
<year>2009</year>
<volume>16</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>377-87</page-range></nlm-citation>
</ref>
<ref id="B52">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Merz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Long]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hiet]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Brügger]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Chlanda]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Andre]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wieland]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Krijnse-Locker]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bartenschlager]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>2011</year>
<volume>286</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>3018-32</page-range></nlm-citation>
</ref>
<ref id="B53">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Understanding the hepatitis C virus life cycle paves the way for highly effective therapies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scheel Troel]]></surname>
<given-names><![CDATA[KH]]></given-names>
</name>
<name>
<surname><![CDATA[Rice Charles]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Med]]></source>
<year>2013</year>
<volume>19</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>837-49</page-range></nlm-citation>
</ref>
<ref id="B54">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[HCV epidemiology, modes of transmission and prevention of spread]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pradat]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Trépo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Baillieres Best Pract Res Clin Gastroenterol]]></source>
<year>2000</year>
<volume>14</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>201-10</page-range></nlm-citation>
</ref>
<ref id="B55">
<nlm-citation citation-type="">
<collab>European center for disease prevention and control (ECDC)</collab>
<source><![CDATA[]]></source>
<year></year>
<volume>55</volume>
</nlm-citation>
</ref>
<ref id="B56">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The prevalence of hepatitis C virus infection in the United States, 1999 through 2002]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Armstrong]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Wasley]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Simard]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[McQuillan]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Kuhnert]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Intern Med]]></source>
<year>2006</year>
<volume>144</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>705-14</page-range></nlm-citation>
</ref>
<ref id="B57">
<nlm-citation citation-type="">
<collab>Center for Disease Control and prevention (CDC)</collab>
<source><![CDATA[Hepatitis C information for health professionals]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B58">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Analysis of hepatitis C virus in hemodialysis patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salvatierra]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Florez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Infectio]]></source>
<year>2015</year>
<volume>20</volume>
<page-range>130-7</page-range></nlm-citation>
</ref>
<ref id="B59">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-Bauer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Forns]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Armelles]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Planas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Solà]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Vergara]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fàbregas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Vega]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Salmerón]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Diago]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Tapias]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Bruguera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hospital admission is a relevant source of hepatitis C virus acquisition in Spain]]></article-title>
<collab>Spanish Acute HCV Study Group</collab>
<source><![CDATA[J Hepatol]]></source>
<year>2008</year>
<volume>48</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>20-7</page-range></nlm-citation>
</ref>
<ref id="B60">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Relationship of cosmetic procedures and drug use to hepatitis C and hepatitis B virus infections in a low-risk population]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hwang]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
<name>
<surname><![CDATA[Kramer]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Troisi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bull]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Grimes]]></surname>
<given-names><![CDATA[CZ]]></given-names>
</name>
<name>
<surname><![CDATA[Lyerla]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2006</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>341-51</page-range></nlm-citation>
</ref>
<ref id="B61">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The epidemiology of hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yen]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Keeffe]]></surname>
<given-names><![CDATA[EB]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmed]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>2003</year>
<volume>36</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>47-53</page-range></nlm-citation>
</ref>
<ref id="B62">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[HIV and hepatitis C co-infection acute HCV therapy]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boesecke]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Vogel]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Opin HIV AIDS]]></source>
<year>2011</year>
<volume>6</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>459-64</page-range></nlm-citation>
</ref>
<ref id="B63">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Natural history of acute and chronic hepatitis C]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maasoumy]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Wedemeyer]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Best Pract Res Clin Gastroenterol]]></source>
<year>2012</year>
<volume>26</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>401-12</page-range></nlm-citation>
</ref>
<ref id="B64">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pathophysiology of hepatitis C virus infection and related liver disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Trends Microbiol]]></source>
<year>2004</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>96-102</page-range></nlm-citation>
</ref>
<ref id="B65">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute hepatitis C virus infection a chronic problem]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blackard]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Shata]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Shire]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sherman]]></surname>
<given-names><![CDATA[KE]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2008</year>
<volume>47</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>321-31</page-range></nlm-citation>
</ref>
<ref id="B66">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The natural history of compensated cirrhosis due to hepatitis C virus A 17-year cohort study of 214 patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sangiovanni]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Prati]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Fasani]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ronchi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Romeo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Manini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Del Ninno]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Morabito]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Colombo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology]]></source>
<year>2006</year>
<volume>43</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1303-10</page-range></nlm-citation>
</ref>
<ref id="B67">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Treatment of chronic hepatitis C in Asia when East meets West]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Chuang]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
</person-group>
<source><![CDATA[J Gastroenterol Hepatol]]></source>
<year>2009</year>
<volume>24</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>336-45</page-range></nlm-citation>
</ref>
<ref id="B68">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thimme]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bukh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Spangenberg]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[Wieland]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pemberton]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Steiger]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Govindarajan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Chisari]]></surname>
<given-names><![CDATA[FV]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2002</year>
<volume>99</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>15661-8</page-range></nlm-citation>
</ref>
<ref id="B69">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neutralizing antibody response during acute and chronic hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Logvinoff]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Major]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Oldach]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Heyward]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Talal]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Balfe]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Feinstone]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[McKeating]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2004</year>
<volume>101</volume>
<numero>27</numero>
<issue>27</issue>
<page-range>10149-54</page-range></nlm-citation>
</ref>
<ref id="B70">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Immunology of hepatitis B virus and hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rehermann]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Nascimbeni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Immunol]]></source>
<year>2005</year>
<volume>5</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>215-29</page-range></nlm-citation>
</ref>
<ref id="B71">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hepatitis C virus particles and lipoprotein metabolism]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Perlemuter]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Budkowska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bréchot]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lotteau]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin Liver Dis]]></source>
<year>2005</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>93-104</page-range></nlm-citation>
</ref>
<ref id="B72">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petit]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Benichou]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Duvillard]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jooste]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bour]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Minello]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Verges]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Brun]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Gambert]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hillon]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Gastroenterol]]></source>
<year>2003</year>
<volume>98</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1150-4</page-range></nlm-citation>
</ref>
<ref id="B73">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Quantification of hepatitis C virus RNA in serum by branched DNA-based signal amplification assays]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Martinot-Peignoux]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Poveda]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Bastie]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Le Breton]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Darthuy]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rémiré]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Erlinger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Dhumeaux]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Marcellin]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[J Virol Methods]]></source>
<year>1999</year>
<volume>79</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>227-35</page-range></nlm-citation>
</ref>
<ref id="B74">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esteban]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of acute hepatitis C]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Arroyo]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Treatment of Liver Disease]]></source>
<year>1999</year>
<page-range>279-86</page-range><publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[Masson]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B75">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Virological techniques for the diagnosis and monitoring of hepatitis B and C]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chevaliez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Hepatol]]></source>
<year>2009</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-12</page-range></nlm-citation>
</ref>
<ref id="B76">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lange]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Sarrazin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic tests in acute and chronic hepatitis C]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Mauss]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Berg]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Rockstroh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sarrazin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wedemeyer]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Hepatology A Clinical Textbook]]></source>
<year>2010</year>
<edition>2</edition>
<publisher-loc><![CDATA[Düsseldorf ]]></publisher-loc>
<publisher-name><![CDATA[Flying Publisher]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B77">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Virology of hepatitis C virus infection Best Pract Res Clin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chevaliez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Gastroenterol]]></source>
<year>2012</year>
<volume>26</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>381-9</page-range></nlm-citation>
</ref>
<ref id="B78">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Analytical performance characteristics and clinical utility of a novel assay for total hepatitis C virus core antigen quantification]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Viazov]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Salloum]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hilgard]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gerken]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Roggendorf]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Microbiol]]></source>
<year>2010</year>
<volume>48</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1161-8</page-range></nlm-citation>
</ref>
<ref id="B79">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Treating viral hepatitis C efficacy, side effects, and complications]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manns]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Wedemeyer]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Cornberg]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Gut]]></source>
<year>2006</year>
<volume>55</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1350-9</page-range></nlm-citation>
</ref>
<ref id="B80">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical Practice Guidelines: Management of hepatitis C virus infection]]></article-title>
<collab>European Association for the Study of the Liver (EASL)</collab>
<source><![CDATA[J Hepatol]]></source>
<year>2014</year>
<volume>60</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>392-420</page-range></nlm-citation>
</ref>
<ref id="B81">
<nlm-citation citation-type="">
<collab>Organización Mundial de la Salud (OMS)</collab>
<source><![CDATA[Guidelines for the screening, care and treatment of persons with hepatitis C infection]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B82">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[How to use virological tools for optimal management of chronic hepatitis C]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chevaliez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pawlotsky]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Liver Int]]></source>
<year>2009</year>
<volume>29</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>9-14</page-range></nlm-citation>
</ref>
<ref id="B83">
<nlm-citation citation-type="book">
<source><![CDATA[Guidance on prevention of viral hepatitis B and C among people who inject drugs]]></source>
<year>2012</year>
<publisher-loc><![CDATA[Geneva ]]></publisher-loc>
<publisher-name><![CDATA[OMS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B84">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rantala]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Surveillance and epidemiology of hepatitis B and C in Europe]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[van de Laar]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Euro Surveill]]></source>
<year>2008</year>
<volume>13</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>18880</page-range></nlm-citation>
</ref>
<ref id="B85">
<nlm-citation citation-type="">
<article-title xml:lang=""><![CDATA[Acute hepatitis C: prevention and treatment]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ozaras]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Tahan]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Expert Rev Anti Infect Ther]]></source>
<year>2009</year>
<volume>7</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>351-61</page-range></nlm-citation>
</ref>
<ref id="B86">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanwal]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hoang]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kramer]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Asch]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Goetz]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Zeringue]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Richardson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[El-Serag]]></surname>
<given-names><![CDATA[HB]]></given-names>
</name>
</person-group>
<source><![CDATA[Gastroenterology]]></source>
<year>2011</year>
<volume>140</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1182-1188.e1</page-range></nlm-citation>
</ref>
<ref id="B87">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The coming wave of HCV-related liver disease dilemmas and challenges]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perz]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Alter]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<source><![CDATA[J Hepatol]]></source>
<year>2006</year>
<volume>44</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>441-3</page-range></nlm-citation>
</ref>
<ref id="B88">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiology of hepatitis B and C viruses: a global overview]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Te]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Jensen]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Liver Dis]]></source>
<year>2010</year>
<volume>14</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-21</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
