<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922017000300192</article-id>
<article-id pub-id-type="doi">10.22354/in.v21i3.677</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Primer caso del síndrome hemofagocítico asociado con posible infección con R ickettsia sp del grupo de las fiebres manchadas, Meta, Colombia]]></article-title>
<article-title xml:lang="en"><![CDATA[First case of haemophagocytic syndrome associated to probable infection with Rickettsia of spotted fever group, Meta, Colombia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Máttar]]></surname>
<given-names><![CDATA[Salim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Contreras]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Cooperativa de Colombia  ]]></institution>
<addr-line><![CDATA[Villavicencio Meta]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Córdoba Instituto de Investigaciones Biológicas del Trópico ]]></institution>
<addr-line><![CDATA[Montería Córdoba]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>21</volume>
<numero>3</numero>
<fpage>192</fpage>
<lpage>194</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922017000300192&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922017000300192&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922017000300192&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El presente estudio describe un caso de síndrome hemofagocítico (SHF) probablemente asociado a la infección por una especie de Rickettsia del grupo de las fiebres manchadas (GFM). La paciente fue una niña de ocho años procedente de un área rural tropical del departamento del Meta, en el Oriente Colombiano, la cual fue admitida en el Hospital de Villavicencio con fiebre alta de tres días de evolución, dolor de cabeza, erupción, astenia, dolor abdominal, linfadenopatias y hepatoesplenomegalia. Los estudios serológicos para HIV, hepatitis, citomegalovirus, virus Epstein Barr entre otros resultaron negativos. La paciente fue admitida en un estudio de fiebres tropicales indiferenciadas, las muestras de suero pareadas fueron analizadas mediante inmunofluorescencia indirecta (IFI) para detección de anticuerpos IgG contra Rickettsia spp., del GFM y se encontró seroconversión de títulos de anticuerpos entre fase aguda (IgG 1:64) y convaleciente (IgG 1:1024). Dada la rápida remisión de las manifestaciones clínicas tras la instauración del tratamiento con doxiciclina, la causa del síndrome hemofagocítico fue atribuido a la infección por Rickettsia spp del GFM.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This study describes a case of hemophagocytic syndrome (SHF) probably associated with infection by a species of Rickettsia spotted fever group (SFG). The patient was an eight years old girl from a rural tropical area of Meta department, in eastern of Colombia, which was admitted to the Hospital of Villavicencio with high fever three days of evolution, headache, rash, asthenia, abdominal pain, lymphadenopathy and hepato-splenomegaly. Serological analyses for HIV, hepatitis, cytomega- lovirus, Epstein Barr virus, and other were negatives. The patient was admitted in undifferentiated tropical fevers and paired serum samples were analyzed through the indirect immunofluorescence assay (IFI) to detect antibodies IgG against Rickettsia of SFG. Antibodies titles in acute phase (IgG 1:64) and convalescent phase (IgG 1:1024) demonstrated seroconvertion. Because the rapid remission of clinical manifestations after treatment with doxiciclina, the cause of hematophagocitic syndrome was attributed to the infection by rickettsia of SFG.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Rickettsia]]></kwd>
<kwd lng="es"><![CDATA[fiebre manchada]]></kwd>
<kwd lng="es"><![CDATA[infección]]></kwd>
<kwd lng="es"><![CDATA[fagocitosis.]]></kwd>
<kwd lng="en"><![CDATA[Rickettsia]]></kwd>
<kwd lng="en"><![CDATA[spotted fever]]></kwd>
<kwd lng="en"><![CDATA[infection]]></kwd>
<kwd lng="en"><![CDATA[phagocytosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Infections associated with haemophagocytic syndrome]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rouphael]]></surname>
<given-names><![CDATA[NG]]></given-names>
</name>
<name>
<surname><![CDATA[Talati]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Vaughan]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Cunningham]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet Infect Dis]]></source>
<year>2007</year>
<numero>7</numero>
<issue>7</issue>
<page-range>81422</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hemophagocytic Syndrome Associated with Cytomegalovirus Infection in a Severely Immunocompromised AIDS Patient: Case Report]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Terra]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Pagot]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Salluh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Braz J Infect Dis]]></source>
<year>2009</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>72-3</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hemophagocytic Syndrome Associated with Scrub Typhus: A Case Report from North East India]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tony]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Roy]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Barman]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Lynrah]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Komut]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Khonglah]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Case Rep]]></source>
<year>2015</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>2-3</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cascio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[l]]></surname>
<given-names><![CDATA[Pernice]]></given-names>
</name>
<name>
<surname><![CDATA[Barberi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Delfino]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Biondo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Beninati]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[European Review for Medical and Pharmacological Sciences]]></source>
<year>2012</year>
<numero>16</numero>
<issue>16</issue>
<page-range>1324-37</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Síndrome hemofagocítico asociado con dengue hemorrágico]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rueda]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Méndez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomédica]]></source>
<year>2002</year>
<volume>22</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>160-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Guías Latinoamericanas de la RIICER para el diagnóstico de las rickettsiosis transmitidas por garrapatas]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oteo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nava]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[de Sousa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Mattar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Venzal]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Abarca]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Labruna]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Zavala-Castro]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Chilena Infectol]]></source>
<year>2014</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>54-65</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Rickettsioses in Latin America, Caribbean, Spain and Portugal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Labruna]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mattar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nava]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bermudez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Venzal]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dolz]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev MVZ Córdoba]]></source>
<year>2011</year>
<numero>16</numero>
<issue>16</issue>
<page-range>2435-57</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hidalgo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Heredia]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Zambrano]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Vesga]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Lizarazo]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Mem Inst Oswaldo Cruz]]></source>
<year>2011</year>
<numero>106</numero>
<issue>106</issue>
<page-range>117-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suarez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hidalgo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Niño]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Vesga]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Orejuela]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Las Rickettsias como agentes etiológicos de entidades febriles no diagnosticadas en Colombia]]></source>
<year>2008</year>
<publisher-loc><![CDATA[Bogotá ]]></publisher-loc>
<publisher-name><![CDATA[Ed. Universidad de los Andes]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Paracoccidioidomicosis diseminada asociada a hipercalcemia y síndrome hemofagocítico]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Arrunategui]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cañas]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Acta Médica Colombiana]]></source>
<year>2008</year>
<volume>33</volume>
<page-range>302-4</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
