<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922017000400202</article-id>
<article-id pub-id-type="doi">10.22354/in.v21i4.682</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de una prueba de biología molecular para la identificación de Mycobacterium tuberculosis y sensibilidad a medicamentos de primera y segunda línea en un hospital de alta complejidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Assessment of a molecular biology test for identification of Mycobacterium tuberculosis and first and second line anti tuberculosis drug susceptibility in a tertiary referral hospital]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peñata-Bedoyaa,*]]></surname>
<given-names><![CDATA[Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Holguín-Velasquezb]]></surname>
<given-names><![CDATA[Anlly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Atehortúa-Muñozc]]></surname>
<given-names><![CDATA[Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vergara-Aguilard]]></surname>
<given-names><![CDATA[Paula]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castaño-Sepúlvedaa,]]></surname>
<given-names><![CDATA[Tatiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bustamante-Miraa]]></surname>
<given-names><![CDATA[Julián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ospina-Ospinaa,c]]></surname>
<given-names><![CDATA[Sigifredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario San Vicente Fundación Biología Molecular e Inmunogenética de trasplantes ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia Escuela de Microbiología ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario San Vicente Fundación Servicio de Microbiología ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Antioquia Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>21</volume>
<numero>4</numero>
<fpage>202</fpage>
<lpage>207</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922017000400202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922017000400202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922017000400202&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objectivo:  Evaluar la utilidad de Anyplex&#8482;II_MTB/MDR/XDR para la detección de Mycobacterium tuberculosis y sensibilidad a medicamentos de primera y segunda línea, además del impacto en la conducta terapéutica en pacientes con sospecha de tuberculosis pulmonar atendidos en una institución de alta complejidad de Medellín, 2014-2015.  Material y Metodos:  Estudio descriptivo de corte trasversal retrospectivo, de pacientes en cuyo proceso de atención se les realizó: baciloscopia, cultivo Ogawa- Kudoh, prueba molecular Anyplex&#8482;II_MTB/MDR/XDR y registro adecuado de historia clínica. Se realizaron medidas estadísticas descriptivas univariadas y de validez diagnóstica.  Resultados:  Se incluyeron 156 muestras de 154 pacientes, de los cuales el 65,6% fueron hombres. El diagnóstico de ingreso más frecuente fue el Virus de la Inmunodeficiencia Humana (VIH) (46,1%). La sensibilidad y especificidad global fue del 96,36% (IC 95%. 90,51 - 100) y 90,51% (IC 95%: 83,62 - 96,38) respectivamente. Se detectó algún tipo de resistencia en el 12,6%. El 57% de los resultados fueron tomados en cuenta por el médico tratante para definir conductas terapéuticas.  Discusión:  Se obtuvo una sensibilidad mayor respecto a otros estudios previos. Entre las limitaciones a destacar están: el diseño retrospectivo y la no disponibilidad de medios de cultivo líquido (MIGIT).  Conclusión:  Anyplex&#8482;II_MTB/MDR/XDR fue útil en la identificación del complejo M. tuberculosis y sensibilidad a medicamentos en muestra directa. El resultado de la prueba influyó en la toma de conductas terapéuticas en más de la mitad de los pacientes con resultados positivos. La implementación de nuevas ayudas diagnósticas, deben estar en concordancia con las necesidades en la atención del paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  To evaluate the utility of Anyplex&#8482;II_MTB/MDR/XDR for detection of Mycobacterium tuberculosis and drug susceptibility testing to first and second line, and the impact on the therapeutic approach, in patients with suspected pulmonary tuberculosis at a reference hospital. Medellin, 2014-2015.  Material and Methods:  This is a retrospective, descriptive, observational study in patients that during its hospitalization were studied by: ZN-smear, Ogawa-Kudoh culture, Anyplex&#8482;II_MTB/MDR/XDR assay and had an adequate record of medical history. Univariate descriptive statistics was performed and accuracy of the test was analyzed.  Results:  156 samples of 154 patients were included, 65.6% were men. The most frequent diagnosis of admission was the Human Immunodeficiency Virus (46.1%). Sensitivity and specificity was 96.36% (95% CI 90.51 to 100) and 90.51% (95% CI 83.62 to 96.38) respectively. Some type of resistance was found in 12.6% of cases. 57% of the results were taken into account to make treatment decisions.  Discussions:  The sensitivity was higher than regarding in previous studies were obtained, comparing with cultures available at institution. Among limitations, this study was retrospective and the unavailability liquid culture medium (MIGIT).  Conclusions:  Anyplex&#8482;II_MTB/MDR/XDR was useful in the identification of mycobacteria and drug susceptibility in direct sample. The result influenced therapeutic decisions in more than half of patients with positive result. The implementation of new diagnostic aids must be in accordance with the needs in patient care.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[reacción en cadena de la polimerasa]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis pulmonar]]></kwd>
<kwd lng="es"><![CDATA[TB-MDR]]></kwd>
<kwd lng="en"><![CDATA[tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[polymerase chain reaction]]></kwd>
<kwd lng="en"><![CDATA[pulmonary tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[MDR-TB]]></kwd>
</kwd-group>
</article-meta>
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